Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats

Lin Xu1, Susan C. Fagan2, Jennifer L. Waller3, David J. Edwards4, Cesar V. Borlongan5, Jianqing Zheng1, W. David Hill6, Giora Feuerstein7, David C. Hess5
1Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
2University of Georgia School of Pharmacy, Augusta, GA, 30912, USA
3Biostatistics and Bioinformatics, Medical College of Georgia, Augusta, GA, 30912, USA
4Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, 48202, USA
5VA Medical Center, Augusta, GA 30904, USA
6Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
7Department of Cardiovascular Diseases, Merck Research Laboratories, West Point, PA, 19486, USA

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Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S: Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci. 2002, 22: 1763-1771.

Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J: Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A. 1998, 95: 15769-15774. 10.1073/pnas.95.26.15769.

Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, Koistinaho J: A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A. 1999, 96: 13496-13500. 10.1073/pnas.96.23.13496.

Tikka TM, Koistinaho JE: Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol. 2001, 166: 7527-7533.

Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM: Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol. 2002, 52: 54-61. 10.1002/ana.10242.

Friedlander RM: Apoptosis and caspases in neurodegenerative diseases. N Engl J Med. 2003, 348: 1365-1375. 10.1056/NEJMra022366.

Wang X, Zhu S, Drozda M, Zhang W, Stavrovskaya IG, Cattaneo E, Ferrante RJ, Kristal BS, Friedlander RM: Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A. 2003, 100: 10483-10487. 10.1073/pnas.1832501100.

Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu du C, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM: Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 2002, 417: 74-78. 10.1038/417074a.

Kriz J, Nguyen MD, Julien JP: Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2002, 10: 268-278. 10.1006/nbdi.2002.0487.

Lee SM, Yune TY, Kim SJ, Park do W, Lee YK, Kim YC, Oh YJ, Markelonis GJ, Oh TH: Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J Neurotrauma. 2003, 20: 1017-1027. 10.1089/089771503770195867.

Wang CX, Yang T, Shuaib A: Effects of minocycline alone and in combination with mild hypothermia in embolic stroke. Brain Res. 2003, 963: 327-329. 10.1016/S0006-8993(02)04045-3.

Ravina BM, Fagan SC, Hart RG, Hovinga CA, Murphy DD, Dawson TM, Marler JR: Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment. Neurology. 2003, 60: 1234-1240.

Wang CX, Yang T, Noor R, Shuaib A: Delayed minocycline but not delayed mild hypothermia protects against embolic stroke. BMC Neurol. 2002, 2: 2-10.1186/1471-2377-2-2.

Saivin S, Houin G: Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet. 1988, 15: 355-366.

Orti V, Audran M, Gibert P, Bougard G, Bressolle F: High-performance liquid chromatographic assay for minocycline in human plasma and parotid saliva. J Chromatogr B Biomed Sci Appl. 2000, 738: 357-365. 10.1016/S0378-4347(99)00547-2.

Zhang RL, Chopp M, Zhang ZG, Jiang Q, Ewing JR: A rat model of focal embolic cerebral ischemia. Brain Res. 1997, 766: 83-92. 10.1016/S0006-8993(97)00580-5.

Power C, Henry S, Del Bigio MR, Larsen PH, Corbett D, Imai Y, Yong VW, Peeling J: Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases. Ann Neurol. 2003, 53: 731-742. 10.1002/ana.10553.

Wells JE, Hurlbert RJ, Fehlings MG, Yong VW: Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice. Brain. 2003, 126: 1628-1637. 10.1093/brain/awg178.

Fagan SC, Edwards DJ, Borlongan CV, Xu L, Arora A, Feuerstein G, Hess DC: Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection. Exp Neurol. 2004, 186: 248-251. 10.1016/j.expneurol.2003.12.006.

Kidwell CS, Liebeskind DS, Starkman S, Saver JL: Trends in acute ischemic stroke trials through the 20th century. Stroke. 2001, 32: 1349-1359.