Low‐Protein Formula Slows Weight Gain in Infants of Overweight Mothers

Journal of Pediatric Gastroenterology and Nutrition - Tập 59 Số 1 - Trang 70-77 - 2014
Jaime Inostroza1, Ferdinand Haschke2, Philippe Steenhout3, Dominik Grathwohl3, Steven E. Nelson4, Ekhard E. Ziegler4
1Department of Basic Sciences, Universidad de La Frontera, Temuco, Chile
2Nestlé Nutrition Institute Vevey Switzerland
3Nestlé R&D Nestec Ltd Vevey Switzerland
4Department of Pediatrics, University of Iowa, Iowa City

Tóm tắt

ABSTRACTObjectives:Infant formulas provide more protein than breast milk. High protein intakes, as well as maternal obesity, are risk factors for later obesity. The present study tested whether a formula with lower protein content slows weight gain of infants of overweight mothers (body mass index [BMI] > 25 kg/m2).Methods:In a randomized double‐blind study infants of overweight mothers received from 3 months an experimental (EXPL) formula with 1.65 g of protein/100 kcal (62.8 kcal/100 mL) and containing probiotics, or a control (CTRL) formula with 2.7 g of protein/100 kcal (65.6 kcal/100 mL). Breast‐fed infants were studied concurrently. Primary assessment was between 3 and 6 months, although formulas were fed until 12 months. Biomarkers of protein metabolism (blood urea nitrogen, insulin growth factor‐1, insulinogenic amino acids) were measured.Results:Infants fed the low‐protein EXPL formula gained less weight between 3 and 6 months (−1.77 g/day, P = 0.024) than infants fed the CTRL formula. In the subgroup of infants of mothers with BMI > 30 kg/m2 the difference was −4.21 g/day (P = 0.017). Weight (P = 0.011) and BMI (P = 0.027) of EXPL infants remained lower than that of CTRL infants until 2 years but were similar to that of breast‐fed infants. Blood urea nitrogen, insulin growth factor‐1, and insulinogenic amino acids at 6 months were significantly lower in EXPL compared with CTRL.Conclusions:A low‐protein formula with probiotics slowed weight gain between 3 and 6 months in infants of overweight mothers. Weight gain and biomarkers were more like those of breast‐fed infants.

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Thông tin xuất bản

Journal of Pediatric Gastroenterology and Nutrition

Tập 59 Số 1

70-77

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