Lovastatin Ameliorates the Development of Glomerulosclerosis and Uremia in Experimental Nephrotic Syndrome

American Journal of Kidney Diseases - Tập 15 Số 1 - Trang 16-23 - 1990
Kevin Harris1, Mabel L. Purkerson, Joel A. Yates, Saulo Klahr
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110

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Tài liệu tham khảo

Klahr, 1988, The progression of renal disease, N Engl J Med, 318, 1657, 10.1056/NEJM198806233182505

Virchow, 1960, A more precise account of fatty metamorphosis, 342

Moorhead, 1982, Lipid nephrotoxicity in chronic progressive glomerular and tubulointerstitial disease, Lancet, 2, 1309, 10.1016/S0140-6736(82)91513-6

Moorhead, 1986, The role of abnormalities of lipid metabolism in the progression of renal disease, 133

Diamond, 1988, Focal and segmental glomerulosclerosis: Analogies to atherosclerosis, Kidney Int, 33, 917, 10.1038/ki.1988.87

Peric-Golia, 1983, Aortic and renal lesions in hypercholesterolemic adult male virgin Sprague-Dawley rats, Atherosclerosis, 46, 57, 10.1016/0021-9150(83)90164-8

French, 1967, Dietary induced glomerulosclerosis in the guinea pig, Arch Pathol, 83, 204

Al-Shebeb, 1988, Glomerular disease in hypercholesterolemic guinea pigs: A pathogenetic study, Kidney Int, 33, 498, 10.1038/ki.1988.26

Wellmann, 1970, Renal changes in experimental hypercholesterolemia in normal and in subdiabetic rabbits, Lab Invest, 22, 144

Diamond, 1987, Excaberation of chronic aminonucleoside nephrosis by dietary cholesterol supplementation, Kidney Int, 32, 671, 10.1038/ki.1987.259

Kasiske, 1988, Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 516 nephrectomy model of chronic renal failure, Circ Res, 62, 367, 10.1161/01.RES.62.2.367

Kasiske, 1988, Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats, Kidney Int, 33, 667, 10.1038/ki.1988.51

Chan, 1981, Lipid abnormalities in uremia, dialysis and transplantation, Kidney Int, 19, 625, 10.1038/ki.1981.62

Baxter, 1962, Hyperlipoproteinemia in nephrosis, Arch Intern Med, 109, 742, 10.1001/archinte.1962.03620180104012

Saito, 1987, The enhancement of aminonucleoside nephrosis by the co-administration of protamine, Kidney Int, 32, 691, 10.1038/ki.1987.262

Alberts, 1980, Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutarylcoenzyme A reductase and a cholesterol lowering agent, Proc Natl Acad Sci USA, 77, 3957, 10.1073/pnas.77.7.3957

Fuhr, 1955, Eine einfache colorimetrische Methode zur Inulinbestimmung fur Nierenclearanceuntersuchungen bei stoffwechselgesunden and Diabetikern, Klin Wochenschr, 33, 729, 10.1007/BF01473295

Kroon, 1982, The effects of mevinolin on serum cholesterol levels of rabbits with endogenous hypercholesterolemia, Atherosclerosis, 44, 41, 10.1016/0021-9150(82)90051-X

Tobert, 1982, Cholesterol-lowering effect of mevinolin, an inhibitor of 3-methylglutaryl-coenzyme A reductase in healthy volunteers, J Clin Invest, 69, 913919, 10.1172/JCI110530

McCune, 1987, Effect of mevinolin on cholesterol metabolism in obese and lean Zucker rats, Biochem Pharmacol, 36, 875, 10.1016/0006-2952(87)90179-1

Vega, 1988, Lovastatin therapy in nephrotic hyperlipidernia: Effects on lipoprotein metabolism, Kidney Int, 33, 1160, 10.1038/ki.1988.125

Rabelink, 1988, Effects of simvastatin and cholestyramine on lipoprotein profile in hyperlipidemia of nephrotic syndrome, Lancet, 2, 1335, 10.1016/S0140-6736(88)90870-7

Anderson, 1988, Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome, J Clin Invest, 82, 1757, 10.1172/JCI113789

Yoshioka, 1988, “Intact nephrons” as the primary origin of proteinuria in chronic renal disease, J Clin Invest, 82, 1614, 10.1172/JCI113773

Purkerson, 1988, N-desulfatedl acetylated heparin ameliorates the progression of renal disease in rats with subtotal renal ablation, J Clin Invest, 81, 69, 10.1172/JCI113312

Diamond, 1986, Nonanticoagulant effect of heparin in chronic aminonucleoside nephrosis, Renal Physiol, 9, 366

Bohrer, 1977, Mechanisms of the puromycin-induced defects in the transglomerular passage of water and macromolecules, J Clin Invest, 60, 152, 10.1172/JCI108751

Deen, 1974, Dynamics of glomerular ultrafiltration in the rat VII, Response to reduced renal mass. Am J Physiol, 227, 556

Grond, 1982, Mesangial function and glomerular sclerosis in rats after unilateral nephrectomy, Kidney Int, 22, 338, 10.1038/ki.1982.178

Rennke, 1986, Structural alterations associated with glomerular hyperfiltration, 133

Moorehead, 1989, Injury to rat mesangial cells in culture by low density lipoproteins, Kidney Int, 35, 433

Diamond, 1989, Aggravating effects of hyperlipidemia on macrophage function, Kidney Int, 35, 426

Nathan, 1987, Secretory products of macrophages, J Clin Invest, 79, 319, 10.1172/JCI112815