Loss of CDX2 Expression and Microsatellite Instability Are Prominent Features of Large Cell Minimally Differentiated Carcinomas of the Colon

The American Journal of Pathology - Tập 159 - Trang 2239-2248 - 2001
Takao Hinoi1, Masachika Tani1,2, Peter C. Lucas3, Karel Caca1, Rodney L. Dunn4, Ettore Macri5, Massimo Loda5, Henry D. Appelman3, Kathleen R. Cho1,3,4, Eric R. Fearon1,3,6,4
1Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
2Biology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo Japan
3Department of Pathology, University of Michigan, Ann Arbor, Michigan
4Department of Cancer Center, University of Michigan, Ann Arbor, Michigan
5Department of Adult Oncology, Dana-Farber Cancer Institute, and the Department of Pathology, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts
6Department of Human Genetics, University of Michigan, Ann Arbor, Michigan

Tài liệu tham khảo

Jessurun, 1999, Medullary adenocarcinoma of the colon: clinicopathologic study of 11 cases, Hum Pathol, 30, 843, 10.1016/S0046-8177(99)90146-6 Ruschoff, 1997, Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics, Am J Pathol, 150, 1815 Reyes, 1997, Anaplastic carcinoma of the colon: clinicopathologic study of eight cases of a poorly recognized lesion, Ann Diag Pathol, 1, 19, 10.1016/S1092-9134(97)80005-6 Sugao, 1997, Improved prognosis of solid-type poorly differentiated colorectal adenocarcinoma: a clinicopathological and immunohistochemical study, Histopathology, 31, 123, 10.1046/j.1365-2559.1997.2320843.x Kawabata, 1999, Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum, Int J Cancer, 84, 33, 10.1002/(SICI)1097-0215(19990219)84:1<33::AID-IJC7>3.0.CO;2-Z Fearon, 1990, A genetic model for colorectal tumorigenesis, Cell, 61, 759, 10.1016/0092-8674(90)90186-I Fearon, 2001, Molecular biology of gastrointestinal cancers, 1037 Kinzler, 1996, Lessons from hereditary colorectal cancer, Cell, 87, 159, 10.1016/S0092-8674(00)81333-1 Marra, 1995, Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives, J Natl Cancer Inst, 87, 1114, 10.1093/jnci/87.15.1114 Lothe, 1993, Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history, Cancer Res, 53, 5849 Risio, 1996, Microsatellite instability is associated with the histological features of the tumor in nonfamilial colorectal cancer, Cancer Res, 56, 5470 Dolcetti, 1999, High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability, Am J Pathol, 154, 1805, 10.1016/S0002-9440(10)65436-3 Forster, 1998, Microsatellite instability in sporadic carcinomas of the proximal colon: association with diploid DNA content, negative protein expression of p53, and distinct histomorphologic features, Surgery, 123, 13, 10.1016/S0039-6060(98)70223-5 Chao, 2000, Patient and tumor characteristics of colon cancers with microsatellite instability: a population-based study, Cancer Epidemiol Biomarkers Prev, 9, 539 Kim, 1994, Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences, Am J Pathol, 145, 148 Alexander, 2001, Histopathological identification of colon cancer with microsatellite instability, Am J Pathol, 158, 527, 10.1016/S0002-9440(10)63994-6 Tamai, 1999, Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice, Cancer Res, 59, 2965 Chawengsaksophak, 1997, Homeosis and intestinal tumours in Cdx2 mutant mice, Nature, 386, 84, 10.1038/386084a0 Beck, 1999, Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice, Proc Natl Acad Sci USA, 96, 7318, 10.1073/pnas.96.13.7318 Ee, 1995, Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma, Am J Pathol, 147, 586 Yagi, 1999, Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas, Br J Cancer, 79, 440, 10.1038/sj.bjc.6690068 Wicking, 1998, CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer, Oncogene, 17, 657, 10.1038/sj.onc.1201971 da Costa, 1999, CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling, Oncogene, 18, 5010, 10.1038/sj.onc.1202872 Kessis, 1996, Rapid identification of patient specimens with microsatellite DNA markers, Mod Pathol, 9, 183 Suzuki, 1990, Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products, Oncogene, 5, 1037 Boland, 1998, A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer, Cancer Res, 58, 5248 Herman, 1998, Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma, Proc Natl Acad Sci USA, 95, 6870, 10.1073/pnas.95.12.6870 Kane, 1997, Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines, Cancer Res, 57, 808 Chaves, 2000, Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype, J Pathol, 191, 355, 10.1002/1096-9896(2000)9999:9999<::AID-PATH644>3.0.CO;2-T Sparks, 1998, Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer, Cancer Res, 58, 1130 Morin, 1997, Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC, Science, 275, 1787, 10.1126/science.275.5307.1787 Munemitsu, 1995, Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein, Proc Natl Acad Sci USA, 92, 3046, 10.1073/pnas.92.7.3046 Webster, 2000, Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding, Genes Chromosom Cancer, 28, 443, 10.1002/1098-2264(200008)28:4<443::AID-GCC10>3.0.CO;2-D Liu, 2000, Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling, Nat Genet, 26, 146, 10.1038/79859 Bos, 1987, Prevalence of ras gene mutations in human colorectal cancers, Nature, 327, 293, 10.1038/327293a0 Ionov, 1993, Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis, Nature, 363, 558, 10.1038/363558a0 Thibodeau, 1993, Microsatellite instability in cancer of the proximal colon, Science, 260, 816, 10.1126/science.8484122 Marra, 1996, DNA repair and colorectal cancer, Gastroenterol Clin North Am, 25, 755, 10.1016/S0889-8553(05)70273-9 Jessurun, 1992, Cecal poorly differentiated adenocarcinoma, medullary type, Mod Pathol, 5, 43A