Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution

Raphaël Millière1
1Faculty of Philosophy, University of Oxford, Oxford, United Kingdom

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Addy, 2011, Acute and post-acute behavioral and psychological effects of salvinorin a in humans, Psychopharmacology (Berl), 220, 195, 10.1007/s00213-011-2470-6

Addy, 2015, The subjective experience of acute, experimentally-induced salvia divinorum inebriation, J. Psychopharmacol., 29, 426, 10.1177/0269881115570081

Albertson, 2009, Subjective effects of salvia divinorum: LSD- or marijuana-like?, J. Psychoactive Drugs, 41, 213, 10.1080/02791072.2009.10400531

Alnæs, 1964, Therapeutic application of the change in consciousness produced Ry psycholytica (LSD, psilocybin, Etc.): the psychedelic experience in the treatment of neurosis, Acta Psychiatr. Scand., 39, 397, 10.1111/j.1600-0447.1964.tb04952.x

Alonso, 2015, Serotonergic psychedelics temporarily modify information transfer in humans, Int. J. Neuropsychopharmacol., 18, pyv039, 10.1093/ijnp/pyv039

Alsmith, 2012, What reason could there be to believe in pre-reflective bodily self-consciousness, Consciousness in Interaction: The Role of the Natural and Social Environment in Shaping Consciousness, 1, 10.1075/aicr.86.01als

Anand, 2000, Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N- methyl-D-aspartate receptor antagonists, Arch. Gen. Psychiatry, 57, 270, 10.1001/archpsyc.57.3.270

Anderson, 1954, Clinical studies of lysergic acid diethylamide, Monatsschr. Psychiatr. Neurol., 128, 38, 10.1159/000139775

Anis, 1983, The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate, Br. J. Pharmacol., 79, 565, 10.1111/j.1476-5381.1983.tb11031.x

Apps, 2014, The free-energy self: a predictive coding account of self-recognition, Neurosci. Biobehav. Rev., 41, 85, 10.1016/j.neubiorev.2013.01.029

Aspell, 2013, Turning body and self inside out visualized heartbeats alter bodily self-consciousness and tactile perception, Psychol. Sci., 24, 2445, 10.1177/0956797613498395

Ataria, 2015, How does it feel to lack a sense of boundaries? A case study of a long-term mindfulness meditator, Conscious. Cogn., 37, 133, 10.1016/j.concog.2015.09.002

Baggott, 2010, Use patterns and self-reported effects of salvia divinorum: an internet-based survey, Drug Alcohol Depend., 111, 250, 10.1016/j.drugalcdep.2010.05.003

Bartolomei, 2012, Rhinal-hippocampal interactions during Déjà vu, Clin. Neurophysiol., 123, 489, 10.1016/j.clinph.2011.08.012

Baumeister, 2002, Mystical self loss: a challenge for psychological theory, Int. J. Psychol. Relig., 12, 15, 10.1207/s15327582ijpr1201_02

Bente, 1958, [EEG findings on the action mechanism of LSD 25], Psychiatr. Neurol. (Basel), 135, 273, 10.1159/000131920

Bercel, 1956, Model psychoses induced by LSD-25 in normals: I. psychophysiological investigations, with special reference to the mechanism of the paranoid reaction, AMA Arch. Neurol. Psychiatry, 75, 588, 10.1001/archneurpsyc.1956.02330240026003

BeringerK. Monographie Neurol Psychiatry H (49)Der Meskalinrausch: Seine Geschichte Und Erscheinungsweise.1927

Bermúdez, 2011, Bodily awareness and self-consciousness, The Oxford Handbook of the Self, 157

Billon, 2015, Jaspers’ dilemma: the psychopathological challenge to subjectivity theories of consciousness, Disturbed Consciousness: New Essays on Psychopathology and Theories of Consciousness, 29, 10.7551/mitpress/9780262029346.003.0002

Blanke, 2012, Multisensory brain mechanisms of bodily self-consciousness, Nat. Rev. Neurosci., 13, 556, 10.1038/nrn3292

Blanke, 2005, The out-of-body experience: disturbed self-processing at the temporo-parietal junction, Neuroscientist, 11, 16, 10.1177/1073858404270885

Blanke, 2009, Full-body illusions and minimal phenomenal selfhood, Trends Cogn. Sci., 13, 7, 10.1016/j.tics.2008.10.003

Blanke, 2015, Behavioral, neural and computational principles of bodily self-consciousness, Neuron, 88, 145, 10.1016/j.neuron.2015.09.029

Blei, 2003, Latent dirichlet allocation, J. Mach. Learn. Res., 3, 993

Bodmer, 1994, Aussergewöhnliche bewusstseinszustände—ihre gemeinsame struktur und messung, Welten Des Bewus Stseins, 3, 45

Botvinick, 1998, Rubber hands ‘feel’ touch that eyes see, Nature, 391, 756, 10.1038/35784

Bowers, 1966, “Psychedelic” experiences in acute psychoses, Arch. Gen. Psychiatry, 15, 240, 10.1001/archpsyc.1966.01730150016003

Braida, 2008, Involvement of κ-Opioid and endocannabinoid system on salvinorin a-induced reward, Biol. Psychiatry, 63, 286, 10.1016/j.biopsych.2007.07.020

Brefczynski-Lewis, 2007, Neural correlates of attentional expertise in long-term meditation practitioners, Proc. Natl. Acad. Sci. U S A, 104, 11483, 10.1073/pnas.0606552104

Bremmer, 2002, Visual-vestibular interactive responses in the macaque ventral intraparietal area (VIP), Eur. J. Neurosci., 16, 1569, 10.1046/j.1460-9568.2002.02206.x

Brewer, 2013, What about the ‘self’ is processed in the posterior cingulate cortex?, Front. Hum. Neurosci., 7, 647, 10.3389/fnhum.2013.00647

Brewer, 2011, Meditation experience is associated with differences in default mode network activity and connectivity, Proc. Natl. Acad. Sci. U S A, 108, 20254, 10.1073/pnas.1112029108

Brogaard, 2016, Psilocybin, lysergic acid diethylamide, mescaline, and drug-induced synesthesia, Neuropathology of Drug Addictions and Substance Misuse, 890, 10.1016/B978-0-12-800212-4.00083-2

Brown, 2013, Active inference, sensory attenuation and illusions, Cogn. Process., 14, 411, 10.1007/s10339-013-0571-3

Buckner, 2008, The brain’s default network: anatomy, function and relevance to disease, Ann. N Y Acad. Sci., 1124, 1, 10.1196/annals.1440.011

Bürgy, 2011, Ego disturbances in the sense of kurt schneider: historical and phenomenological aspects, Psychopathology, 44, 320, 10.1159/000325059

Calvert, 2000, Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex, Curr. Biol., 10, 649, 10.1016/s0960-9822(00)00513-3

Carhart-Harris, 2012, Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin, Proc. Natl. Acad. Sci. U S A, 109, 2138, 10.1073/pnas.1119598109

Carhart-Harris, 2010, The default-mode, ego-functions and free-energy: a neurobiological account of freudian ideas, Brain, 133, 1265, 10.1093/brain/awq010

Carhart-Harris, 2013, Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis, Schizophr. Bull., 39, 1343, 10.1093/schbul/sbs117

Carhart-Harris, 2014, The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs, Front. Hum. Neurosci., 8, 20, 10.3389/fnhum.2014.00020

Carhart-Harris, 2016, Neural correlates of the lsd experience revealed by multimodal neuroimaging, Proc. Natl. Acad. Sci. U S A, 113, 4853, 10.1073/pnas.1518377113

Carter, 2007, Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans, Psychopharmacology (Berl), 195, 415, 10.1007/s00213-007-0930-9

Chalmers, 2000, What is a neural correlate of consciousness?, Neural Correlates of Consciousness, 17, 10.7551/mitpress/4928.003.0004

Chambers, 1999, Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation, Semin. Clin. Neuropsychiatry, 4, 274

Christoff, 2011, Specifying the self for cognitive neuroscience, Trends Cogn. Sci., 15, 104, 10.1016/j.tics.2011.01.001

Clark, 2013, Whatever next? predictive brains, situated agents, and the future of cognitive science, Behav. Brain Sci., 36, 181, 10.1017/S0140525x12000477

Cohen, 1960, Lysergic acid diethylamide: side effects and complications, J. Nerv. Ment. Dis., 130, 30, 10.1097/00005053-196001000-00005

Corlett, 2007, From prediction error to psychosis: ketamine as a pharmacological model of delusions, J. Psychopharmacol., 21, 238, 10.1177/0269881107077716

Quantitative analysis of narrative reports of psychedelic drugs CoyleJ. R. PrestiD. E. BaggottM. J. arXiv:1206.0312 [Q-Bio].2012

Craig, 2009, How do you feel—now? The anterior insula and human awareness, Nat. Rev. Neurosci., 10, 59, 10.1038/nrn2555

Cummins, 2013, Peak experiences of psilocybin users and non-users, J. Psychoactive Drugs, 45, 189, 10.1080/02791072.2013.785855

Damasio, 1999, The Feeling of What Happens: Body and Emotion in the Making of Consciousness.

De Simoni, 2013, Test-retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers, Neuroimage, 64, 75, 10.1016/j.neuroimage.2012.09.037

Deakin, 2008, Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study, Arch. Gen. Psychiatry, 65, 154, 10.1001/archgenpsychiatry.2007.37

Dehaene, 2014, Toward a computational theory of conscious processing, Curr. Opin. Neurobiol., 25, 76, 10.1016/j.conb.2013.12.005

Denber, 1958, Studies on mescaline viii: psychodynamic observations, Am. J. Psychiatry, 115, 239, 10.1176/ajp.115.3.239

Dittrich, 1975, Zusammenstellung Eines Fragebogens (APZ) Zur Erfassung abnormer psychischer Zustände [Construction of a questionnaire (APZ) for assessing abnormal mental states], Z. Klin Psychol. Psychiatr. Psychother., 23, 12

Dittrich, 1996, Ätiologie-Unabhängige Strukturen Veränderter Wachbewusstseinszustände. Ergebnisse Empirischer Untersuchungen Über Halluzinogene I. Und II. Ordnung, Sensorische Deprivation, Hypnagoge Zustände, Hypnotische Verfahren Sowie Reizüberflutung.

Dittrich, 1998, The standardized psychometric assessment of altered states of consciousness (ASCs) in humans, Pharmacopsychiatry, 31, 80, 10.1055/s-2007-979351

Dittrich, 2006, 5D-ABZ: Fragebogen Zur Erfassung Aussergewöhnlicher Bewusstseinszustände. Eine Kurze Einführung.

Dittrich, 2010, 5D-ASC: Questionnaire for the Assessment of Altered States of Consciousness. A Short Introduction.

Dor-Ziderman, 2013, Mindfulness-induced selflessness: a MEG neurophenomenological study, Front. Hum. Neurosci., 7, 582, 10.3389/fnhum.2013.00582

Doya, 2006, Bayesian Brain: Probabilistic Approaches to Neural Coding., 10.7551/mitpress/9780262042383.001.0001

Ebner, 2010, Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens, Psychopharmacology (Berl), 210, 241, 10.1007/s00213-010-1836-5

Eddy, 2016, The junction between self and other? Temporo-parietal dysfunction in neuropsychiatry, Neuropsychologia, 89, 465, 10.1016/j.neuropsychologia.2016.07.030

Ehrsson, 2007, The experimental induction of out-of-body experiences, Science, 317, 1048, 10.1126/science.1142175

Eisner, 1958, Psychotherapy with lysergic acid diethylamide, J. Nerv. Ment. Dis., 127, 528, 10.1097/00005053-195812000-00006

Emrich, 1989, A three-component-system hypothesis of psychosis. Impairment of binocular depth inversion as an indicator of a functional dysequilibrium, Br. J. Psychiatry, 37, 10.1192/S0007125000295962

Ernst, 2002, Humans integrate visual and haptic information in a statistically optimal fashion, Nature, 415, 429, 10.1038/415429a

Fetsch, 2011, Neural correlates of reliability-based cue weighting during multisensory integration, Nat. Neurosci., 15, 146, 10.1038/nn.2983

Fletcher, 2009, Perceiving is believing: a bayesian approach to explaining the positive symptoms of schizophrenia, Nat. Rev. Neurosci., 10, 48, 10.1038/nrn2536

Frecska, 2003, Effects of the amazonian psychoactive beverage ayahuasca on binocular rivalry: interhemispheric switching or interhemispheric fusion?, J. Psychoactive Drugs, 35, 367, 10.1080/02791072.2003.10400019

Bálint’s syndrome and the structure of visual experience FrenchC. 2015

Friston, 2010, The free-energy principle: a unified brain theory?, Nat. Rev. Neurosci., 11, 127, 10.1038/nrn2787

Gallagher, 2000, Philosophical conceptions of the self: implications for cognitive science, Trends Cogn. Sci., 4, 14, 10.1016/s1364-6613(99)01417-5

Gallagher, 2003, Phenomenology and experimental design: toward a phenomenologically enlightened experimental science, J. Conscious. Stud., 10, 85

Phenomenological approaches to self-consciousness GallagherS. ZahaviD. 2005

Gehrke, 2008, Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum, Psychopharmacology (Berl), 197, 509, 10.1007/s00213-007-1067-6

Gennaro, 2012, The Consciousness Paradox: Consciousness, Concepts, and Higher-Order Thoughts.

Glennon, 1984, Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents, Life Sci., 35, 2505, 10.1016/0024-3205(84)90436-3

González, 2006, Pattern of use and subjective effects of salvia divinorum among recreational users, Drug Alcohol Depend., 85, 157, 10.1016/j.drugalcdep.2006.04.001

Gouzoulis-Mayfrank, 1998, Hallucinogenic drug induced states resemble acute endogenous psychoses: results of an empirical study, Eur. Psychiatry, 13, 399, 10.1016/S0924-9338(99)80686-5

Gouzoulis-Mayfrank, 2005, Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): a double-blind, cross-over study in healthy volunteers, Pharmacopsychiatry, 38, 301, 10.1055/s-2005-916185

Griffiths, 2011, Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects, Psychopharmacology (Berl), 218, 649, 10.1007/s00213-011-2358-5

Griffiths, 2006, Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance, Psychopharmacology (Berl), 187, 284, 10.1007/s00213-006-0457-5

Grof, 1970, The use of LSD in psychotherapy, J. Psychedelic Drugs, 3, 52, 10.1080/02791072.1970.10471362

Grosz, 2015, Being-in-the-world and schizophrenia, Psychology and the Other, 247, 10.1093/acprof:oso/9780199324804.003.0017

Gruhle, 1915, Selbstschilderung und einfühlung, Z. Gesamte Neurol. Psychiatr., 27, 148, 10.1007/BF02866667

Guillot, 2017, I me mine: on a confusion concerning the subjective character of experience, Rev. Philos. Psychol., 8, 23, 10.1007/s13164-016-0313-4

Gusnard, 2001, Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function, Proc. Natl. Acad. Sci. U S A, 98, 4259, 10.1073/pnas.071043098

Guterstam, 2015, Posterior cingulate cortex integrates the senses of self-location and body ownership, Curr. Biol., 25, 1416, 10.1016/j.cub.2015.03.059

Guttmann, 1937, Mescaline and depersonalization, J. Neurol. Psychopathol., 16, 193

Halberstadt, 2015, Recent advances in the neuropsychopharmacology of serotonergic hallucinogens, Behav. Brain Res., 277, 99, 10.1016/j.bbr.2014.07.016

Halgren, 1978, Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala, Brain, 101, 83, 10.1093/brain/101.1.83

Hasler, 2004, Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study, Psychopharmacology (Berl), 172, 145, 10.1007/s00213-003-1640-6

Heydrich, 2013, Distinct illusory own-body perceptions caused by damage to posterior insula and extrastriate cortex, Brain, 136, 790, 10.1093/brain/aws364

Hohwy, , Why should any body have a self?, The Subject’s Matter: Self-Consciousness and the Body, 10.31234/osf.io/fm4cr

Hood, 2002, The mystical self: lost and found, Int. J. Psychol. Relig., 12, 1, 10.1207/s15327582ijpr1201_01

Huang, 2017, The sense of 1PP-location contributes to shaping the perceived self-location together with the sense of body-location, Front. Psychol., 8, 370, 10.3389/fpsyg.2017.00370

Husserl, 1959, Erste Philosophie, 1923/24: Zweiter Teil: Theorie der phänomenologische Reduktion

Huxley, 1954, The Doors of Perception and Heaven and Hell.

Ionta, 2011, Multisensory mechanisms in temporo-parietal cortex support self-location and first-person perspective, Neuron, 70, 363, 10.1016/j.neuron.2011.03.009

Javitt, 1996, Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia, Proc. Natl. Acad. Sci. U S A, 93, 11962, 10.1073/pnas.93.21.11962

Javitt, 2012, Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia, Schizophr. Bull., 38, 958, 10.1093/schbul/sbs069

Johnson, 2011, Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant salvia divinorum, Drug Alcohol Depend., 115, 150, 10.1016/j.drugalcdep.2010.11.005

Josipovic, 2012, Influence of meditation on anti-correlated networks in the brain, Front. Hum. Neurosci., 5, 183, 10.3389/fnhum.2011.00183

Kast, 1964, Study of lysergic acid diethylamide as an analgesic agent, Anesth. Analg., 43, 285, 10.1213/00000539-196405000-00013

Keefe, 2011, Failures in learning-dependent predictive perception as the key cognitive vulnerability to psychosis in schizophrenia, Neuropsychopharmacology, 36, 367, 10.1038/npp.2010.153

Klee, 1963, Lysergic acid diethylamide (Lsd-25) and ego functions, Arch. Gen. Psychiatry, 8, 461, 10.1001/archpsyc.1963.01720110037005

Kriegel, 2005, Naturalizing subjective character, Phil. Phenomenol. Res., 71, 23, 10.1111/j.1933-1592.2005.tb00429.x

Kriegel, 2009, Subjective Consciousness: A Self-Representational Theory., 10.1093/acprof:oso/9780199570355.001.0001

Krystal, 1994, Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses, Arch. Gen. Psychiatry, 51, 199, 10.1001/archpsyc.1994.03950030035004

Lahti, 1995, Subanesthetic doses of ketamine stimulate psychosis in schizophrenia, Neuropsychopharmacology, 13, 9, 10.1038/sj.npp.1380271

Lane, 2015, Self, belonging, and conscious experience: a critique of subjectivity theories of consciousness, Disturbed Consciousness: New Essays on Psychopathology and Theories of Consciousness, 103, 10.7551/mitpress/9780262029346.003.0005

Leary, 1964, The Psychedelic Experience: Manual Based on the Tibetan Book of the Dead.

Lebedev, 2016, LSD-induced entropic brain activity predicts subsequent personality change, Hum. Brain Mapp., 37, 3203, 10.1002/hbm.23234

Lebedev, 2015, Finding the self by losing the self: neural correlates of ego-dissolution under psilocybin, Hum. Brain Mapp., 36, 3137, 10.1002/hbm.22833

Legrand, 2006, The bodily self: the sensori-motor roots of pre-reflective self-consciousness, Phenomenol. Cogn. Sci., 5, 89, 10.1007/S11097-005-9015-6

Legrand, 2009, What is self-specific? Theoretical investigation and critical review of neuroimaging results, Psychol. Rev., 116, 252, 10.1037/a0014172

Lemche, 2016, Dissociable brain correlates for depression, anxiety, dissociation, and somatization in depersonalization-derealization disorder, CNS Spectr., 21, 35, 10.1017/S1092852913000588

Lenggenhager, 2009, Spatial aspects of bodily self-consciousness, Conscious. Cogn., 18, 110, 10.1016/j.concog.2008.11.003

Lenggenhager, 2007, Video ergo sum: manipulating bodily self-consciousness, Science, 317, 1096, 10.1126/science.1143439

Letheby, , Self unbound: ego dissolution in psychedelic experience, Neurosci. Conscious.

Levine, 2001, Purple Haze: The Puzzle of Consciousness., 10.1093/0195132351.001.0001

Lewis, 1958, Therapy with lysergic acid diethylamide, J. Clin. Exp. Psychopathol., 19, 19

Limanowski, 2014, What can body ownership illusions tell us about minimal phenomenal selfhood?, Front. Hum. Neurosci., 8, 946, 10.3389/fnhum.2014.00946

Limanowski, 2013, Minimal self-models and the free energy principle, Front. Hum. Neurosci., 7, 547, 10.3389/fnhum.2013.00547

Lou, 2016, Towards a cognitive neuroscience of self-awareness, Neurosci. Biobehav. Rev., 10.1016/j.neubiorev.2016.04.004

MacDonald, 2015, Anesthesia and neuroimaging: investigating the neural correlates of unconsciousness, Trends Cogn. Sci., 19, 100, 10.1016/j.tics.2014.12.005

Macpherson, 2015, The structure of experience, the nature of the visual and type 2 blindsight, Conscious. Cogn., 32, 104, 10.1016/j.concog.2014.10.011

Maqueda, 2015, Salvinorin-A induces intense dissociative effects, blocking external sensory perception and modulating interoception and sense of body ownership in humans, Int. J. Neuropsychopharmacol., 18, pyv065, 10.1093/ijnp/pyv065

Maselli, 2015, Allocentric and egocentric manipulations of the sense of self-location in full-body illusions and their relation with the sense of body ownership, Cogn. Process., 16, 309, 10.1007/s10339-015-0667-z

Mayer-Gross, 1926, Über einige abänderungen der sinnestätigkeit im Meskalinrausch, Z. Gesamte Neurol. Psychiatr., 101, 354, 10.1007/bf02878343

McGlothlin, 1964, Hallucinogenic Drugs: A Perspective with Special Reference to Peyote and Cannabis.

Metzinger, 2003, Being No One: The Self-Model Theory of Subjectivity., 10.7551/mitpress/1551.001.0001

Metzinger, 2013, Why are dreams interesting for philosophers? The example of minimal phenomenal selfhood, plus an agenda for future research, Front. Psychol., 4, 746, 10.3389/fpsyg.2013.00746

Metzner, 1965, The relation of expectation and mood to psilocybin reactions: a questionnaire study, Psychedelic Rev., 5, 339

Mishara, 2007, Is minimal self preserved in schizophrenia? a subcomponents view, Conscious. Cogn., 16, 715, 10.1016/j.concog.2007.07.009

Mishara, 2016, Neurobiological models of self-disorders in early schizophrenia, Schizophr. Bull., 42, 874, 10.1093/schbul/sbv123

Mishara, 2014, Self-disturbances in schizophrenia: history, phenomenology, and relevant findings from research on metacognition, Schizophr. Bull., 40, 5, 10.1093/schbul/sbt169

Moghaddam, 1997, Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex, J. Neurosci., 17, 2921, 10.1523/JNEUROSCI.17-08-02921.1997

Mole, 2008, Attention and consciousness, J. Conscious. Stud., 15, 86

Morgan, 2011, Exploring the impact of ketamine on the experience of illusory body ownership, Biol. Psychiatry, 69, 35, 10.1016/j.biopsych.2010.07.032

Moutoussis, 2014, Bayesian inferences about the self (and Others): a review, Conscious. Cogn., 25, 67, 10.1016/j.concog.2014.01.009

Musholt, 2013, A philosophical perspective on the relation between cortical midline structures and the self, Front. Hum. Neurosci., 7, 536, 10.3389/fnhum.2013.00536

Muthukumaraswamy, 2013, Broadband cortical desynchronization underlies the human psychedelic state, J. Neurosci., 33, 15171, 10.1523/JNEUROSCI.2063-13.2013

Nagel, 1974, What is it like to be a bat?, Philos. Rev., 83, 435, 10.2307/2183914

Nelson, , What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: integrating phenomenology and neurocognition. Part 1 (Source monitoring deficits), Schizophr. Res., 152, 12, 10.1016/j.schres.2013.06.022

Nelson, , What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: integrating phenomenology and neurocognition. Part 2 (Aberrant salience), Schizophr. Res., 152, 20, 10.1016/j.schres.2013.06.033

Newell, 2005, Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients, Neuroreport, 16, 1363, 10.1097/01.wnr.0000174056.11403.71

Nichols, 2004, Hallucinogens, Pharmacol. Ther., 101, 131, 10.1016/j.pharmthera.2003.11.002

Noel, 2017, The spatial self in schizophrenia and autism spectrum disorder, Schizophr. Res., 179, 8, 10.1016/j.schres.2016.09.021

Noel, 2015, Peripersonal space as the space of the bodily self, Cognition, 144, 49, 10.1016/j.cognition.2015.07.012

Northoff, 2004, Cortical midline structures and the self, Trends Cogn. Sci., 8, 102, 10.1016/j.tics.2004.01.004

Northoff, 2005, NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI, Schizophr. Res., 72, 235, 10.1016/j.schres.2004.04.009

Nour, 2015, Schizophrenia, subjectivity, and mindreading, Schizophr. Bull., 41, 1214, 10.1093/schbul/sbv035

Nour, 2017, Psychedelics and the science of self-experience, Br. J. Psychiatry, 210, 177, 10.1192/bjp.bp.116.194738

Nour, 2016, Ego-dissolution and psychedelics: validation of the ego-dissolution inventory (EDI), Front. Hum. Neurosci., 10, 269, 10.3389/fnhum.2016.00269

Nuller, 2001, Effect of naloxone therapy on depersonalization: a pilot study, J. Psychopharmacol., 15, 93, 10.1177/026988110101500205

Ochsner, 2005, The neural correlates of direct and reflected self-knowledge, Neuroimage, 28, 797, 10.1016/j.neuroimage.2005.06.069

Olney, 1989, Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs, Science, 244, 1360, 10.1126/science.2660263

Osmond, 1957, A review of the clinical effects of psychotomimetic agents, Ann. N Y Acad. Sci., 66, 418, 10.1111/j.1749-6632.1957.tb40738.x

Pahnke, 1969, The psychedelic mystical experience in the human encounter with death, Harv. Theol. Rev., 62, 1, 10.1017/S0017816000027577

Pahnke, 1966, Drugs and Mysticism: An Analysis of the Relationship between Psychedelic Drugs and the Mystical Consciousness.

Pahnke, 1969, LSD-assisted psychotherapy with terminal cancer patients, Curr. Psychiatr. Ther., 9, 144

Pahnke, 1966, Implications of LSD and experimental mysticism, J. Relig. Health, 5, 175, 10.1007/BF01532646

Palhano-Fontes, 2015, The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network, PLoS One, 10, e0118143, 10.1371/journal.pone.0118143

Pazos, 1987, Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors, Neuroscience, 21, 123, 10.1016/0306-4522(87)90326-5

Peckys, 1999, Expression of Mu, Kappa, and delta opioid receptor messenger RNA in the human CNS: a 33P in situ hybridization study, Neuroscience, 88, 1093, 10.1016/s0306-4522(98)00251-6

Petitmengin, 2006, Describing one’s subjective experience in the second person: an interview method for the science of consciousness, Phenomenol. Cogn. Sci., 5, 229, 10.1007/s11097-006-9022-2

Petitmengin, 2013, Microcognitive science: bridging experiential and neuronal microdynamics, Front. Hum. Neurosci., 7, 617, 10.3389/fnhum.2013.00617

Petitmengin, , What is it like to meditate? Methods and issues for a micro-phenomenological description of meditative experience, J. Conscious. Stud.

Pfeiffer, 1986, Psychotomimesis mediated by kappa opiate receptors, Science, 233, 774, 10.1126/science.3016896

Pfeiffer, 2013, Multisensory origin of the subjective first-person perspective: visual, tactile, and vestibular mechanisms, PLoS One, 8, e61751, 10.1371/journal.pone.0061751

Attention and conscious perception. Thesis PrettymanA. 2014

Qin, 2013, Why and how is the self-related to the brain midline regions?, Front. Hum. Neurosci., 7, 909, 10.3389/fnhum.2013.00909

Qin, 2011, How is our self related to midline regions and the default-mode network?, Neuroimage, 57, 1221, 10.1016/j.neuroimage.2011.05.028

Raichle, 2001, A default mode of brain function, Proc. Natl. Acad. Sci. U S A, 98, 676, 10.1073/pnas.98.2.676

Reissig, 2012, High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens, Psychopharmacology (Berl), 223, 1, 10.1007/s00213-012-2680-6

Riba, 2002, Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively, Psychopharmacology (Berl), 165, 18, 10.1007/s00213-002-1237-5

Rosenthal, 1997, A theory of consciousness, The Nature of Consciousness, 729

Roth, 2002, Salvinorin a: a potent naturally occurring nonnitrogenous kappa opioid selective agonist, Proc. Natl. Acad. Sci. U S A, 99, 11934, 10.1073/pnas.182234399

Rümmele, 1961, Untersuchungen mit psilocybin, einer psychotropen substanz aus psilocybe mexicana, Schweiz. Arch. Neurol. Neurochir. Psychiatr., 87, 365

Sadzot, 1989, Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesis, Psychopharmacology (Berl), 98, 495, 10.1007/bf00441948

Salomon, 2017, The assembly of the self from sensory and motor foundations, Soc. Cogn., 35, 87, 10.1521/soco.2017.35.2.87

Samad, 2015, Perception of body ownership is driven by bayesian sensory inference, PLoS One, 10, e0117178, 10.1371/journal.pone.0117178

Sartre, 1943, L’être et Le Néant.

Sass, 2011, Phenomenological psychopathology and schizophrenia: contemporary approaches and misunderstandings, Philos. Psychiatr. Psychol., 18, 1, 10.1353/ppp.2011.0008

Sass, 2013, Anomalous self-experience in depersonalization and schizophrenia: a comparative investigation, Conscious. Cogn., 22, 430, 10.1016/j.concog.2013.01.009

Savage, 1955, Variations in ego feeling induced by D-lysergic acid diethylamide (LSD-25), Psychoanal. Rev., 42, 1

Scharfetter, 1981, Ego-psychopathology: the concept and its empirical evaluation, Psychol. Med., 11, 273, 10.1017/s0033291700052090

Scheidegger, 2012, Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action, PLoS One, 7, e44799, 10.1371/journal.pone.0044799

Schmidt, 2012, Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments, Neuropsychopharmacology, 37, 865, 10.1038/npp.2011.261

Schneider, 1959, Clinical Psychopathology.

Schwitzgebel, 2007, Do you have constant tactile experience of your feet in your shoes? Or is experience limited to what’s in attention?, J. Conscious. Stud., 14, 5

Sedman, 1964, The occurrence of depersonalization phenomena under LSD, Psychiatr. Neurol. (Basel), 147, 129, 10.1159/000128893

Serino, 2013, Bodily ownership and self-location: components of bodily self-consciousness, Conscious. Cogn., 22, 1239, 10.1016/j.concog.2013.08.013

Seth, 2013, Interoceptive inference, emotion, and the embodied self, Trends Cogn. Sci., 17, 565, 10.1016/j.tics.2013.09.007

Seth, 2012, An interoceptive predictive coding model of conscious presence, Front. Psychol., 2, 395, 10.3389/fpsyg.2011.00395

Sharp, 1991, MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex, Ann. Neurol., 30, 801, 10.1002/ana.410300609

Sierra, 2008, Depersonalization disorder: pharmacological approaches, Expert Rev. Neurother., 8, 19, 10.1586/14737175.8.1.19

Sierra, 2006, Lamotrigine as an add-on treatment for depersonalization disorder: a retrospective study of 32 cases, Clin. Neuropharmacol., 29, 253, 10.1097/01.WNF.0000228368.17970.da

Sierra, 2001, Lamotrigine in the treatment of depersonalization disorder, J. Clin. Psychiatry, 62, 826, 10.4088/jcp.v62n1012b

Simeon, 2005, An open trial of naltrexone in the treatment of depersonalization disorder, J. Clin. Psychopharmacol., 25, 267, 10.1097/01.jcp.0000162803.61700.4f

Spence, 2004, Crossmodal Space and Crossmodal Attention., 10.1093/acprof:oso/9780198524861.001.0001

Sterzer, 2016, Thought insertion as a self-disturbance: an integration of predictive coding and phenomenological approaches, Front. Hum. Neurosci., 10, 502, 10.3389/fnhum.2016.00502

Stiefel, 2014, The claustrum’s proposed role in consciousness is supported by the effect and target localization of salvia divinorum, Front. Integr. Neurosci., 8, 20, 10.3389/fnint.2014.00020

Strawson, 2000, The phenomenology and ontology of the self, Exploring the Self, 23, 10.1075/aicr.23.05str

Strawson, 2011, Selves: An Essay in Revisionary Metaphysics.

Strassman, 1994, Dose-response study of N,N-dimethyltryptamine in humans: II. Subjective effects and preliminary results of a new rating scale, Arch. Gen. Psychiatry, 51, 98, 10.1001/archpsyc.1994.03950020022002

Studerus, 2012, Prediction of psilocybin response in healthy volunteers, PLoS One, 7, e30800, 10.1371/journal.pone.0030800

Studerus, 2010, Psychometric evaluation of the altered states of consciousness rating scale (OAV), PLoS One, 5, e12412, 10.1371/journal.pone.0012412

Studerus, 2011, Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies, J. Psychopharmacol., 25, 1434, 10.1177/0269881110382466

Suzuki, 2013, Multisensory integration across exteroceptive and interoceptive domains modulates self-experience in the rubber-hand illusion, Neuropsychologia, 51, 2909, 10.1016/j.neuropsychologia.2013.08.014

Tagliazucchi, 2016, Increased global functional connectivity correlates with LSD-induced ego dissolution, Curr. Biol., 26, 1043, 10.1016/j.cub.2016.02.010

Thakkar, 2011, Disturbances in body ownership in schizophrenia: evidence from the rubber hand illusion and case study of a spontaneous out-of-body experience, PLoS One, 6, e27089, 10.1371/journal.pone.0027089

Titeler, 1988, Radioligand Binding Evidence Implicates the Brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens, Psychopharmacology (Berl), 94, 213, 10.1007/bf00176847

Uddin, 2011, Brain connectivity and the self: the case of cerebral disconnection, Conscious. Cogn., 20, 94, 10.1016/j.concog.2010.09.009

Valenzuela Moguillansky, 2013, Exploring the subjective experience of the “rubber hand” illusion, Front. Hum. Neurosci., 7, 659, 10.3389/fnhum.2013.00659

Varela, 1996, Neurophenomenology: a methodological remedy for the hard problem, J. Conscious. Stud., 3, 330

Vermersch, 1994, L’entretien d’explicitation

Vollenweider, 2001, A systems model of altered consciousness: integrating natural and drug-induced psychoses, Brain Res. Bull., 56, 495, 10.1016/s0361-9230(01)00646-3

Vollenweider, 2010, The neurobiology of psychedelic drugs: implications for the treatment of mood disorders, Nat. Rev. Neurosci., 11, 642, 10.1038/nrn2884

Vollenweider, , Ifferential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET), Eur. Neuropsychopharmacol., 7, 25, 10.1016/s0924-977x(96)00042-9

Vollenweider, , Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG), Eur. Neuropsychopharmacol., 7, 9, 10.1016/s0924-977x(96)00039-9

Vollenweider, , Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis, Neuropsychopharmacology, 16, 357, 10.1016/s0893-133x(96)00246-1

Vollenweider, 1998, Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action, Neuroreport, 9, 3897, 10.1097/00001756-199812010-00024

Von Mering, 1957, Experimentally induced depersonalization, Experimental Psychopathology, 66

Walsh, 2001, Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans, Psychopharmacology (Berl), 157, 151, 10.1007/s002130100788

Ward, 2014, The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system, Hum. Brain Mapp., 35, 1061, 10.1002/hbm.22234

Weber, 2010, Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice, Front. Neurosci., 4, 36, 10.3389/fnins.2010.00036

Willmore-Fordham, 2007, The hallucinogen derived from salvia divinorum, salvinorin A, has κ-opioid agonist discriminative stimulus effects in rats, Neuropharmacology, 53, 481, 10.1016/j.neuropharm.2007.06.008

Windt, 2010, The immersive spatiotemporal hallucination model of dreaming, Phenomenol. Cogn. Sci., 9, 295, 10.1007/s11097-010-9163-1

Windt, 2015, Dreaming: A Conceptual Framework for Philosophy of Mind and Empirical Research., 10.7551/mitpress/9780262028677.001.0001

Wolbach, 1962, Comparison of psilocin with psilocybin, mescaline and LSD-25, Psychopharmacologia, 3, 219, 10.1007/bf00412109

Yu, 2012, Mapping the central effects of chronic ketamine administration in an adolescent primate model by functional magnetic resonance imaging (fMRI), Neurotoxicology, 33, 70, 10.1016/j.neuro.2011.11.001

Zahavi, 2004, Phenomenology and the project of naturalization, Phenomenol. Cogn. Sci., 3, 331, 10.1023/b:phen.0000048935.94012.4e

Zahavi, 2005, Subjectivity and Selfhood: Investigating the First-Person Perspective., 10.7551/mitpress/6541.001.0001

Zahavi, 2010, Minimal self and narrative self. A distinction in need of refinement, The Embodied Self: Dimensions, Coherence, and Disorders, 3

Zahavi, 2014, Self and Other: Exploring Subjectivity, Empathy, and Shame., 10.1093/acprof:oso/9780199590681.001.0001

Zahavi, 2016, For-me-ness: what it is and what it is not, Philosophy of Mind and Phenomenology: Conceptual and Empirical Approaches, 36