Looking beyond 5-HT3 receptors: A review of the wider role of serotonin in the pharmacology of nausea and vomiting

European Journal of Pharmacology - Tập 722 - Trang 13-25 - 2014
Kevin D. Johnston1, Zengbing Lu2, John A. Rudd2
1Department of Anesthesia, School of Medicine, The University of Leeds, Leeds, West Yorkshire, England
2Emesis Research Group, Neuro-degeneration, Development and Repair, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

Tài liệu tham khảo

Alfieri, 1995, Comparative efficacy of a single oral dose of ondansetron and of buspirone against cisplatin-induced emesis in cancer patients, Br. J. Cancer, 72, 1013, 10.1038/bjc.1995.452 Alfieri, 1995, Treatment with para-chlorophenylalanine antagonises the emetic response and the serotonin-releasing actions of cisplatin in cancer patients, Br. J. Cancer, 71, 629, 10.1038/bjc.1995.123 Anderson, 1990, The effects of gepirone on neuroendocrine function and temperature in humans, Psychopharmacology, 100, 498, 10.1007/BF02244002 Andrews, 1996, The pharmacology of the emetic response to upper gastrointestinal tract stimulation in Suncus murinus, Eur. J. Pharmacol., 307, 305, 10.1016/0014-2999(96)00275-0 Andrews, 1990, The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity, Can. J. Physiol. Pharmacol., 68, 325, 10.1139/y90-047 Andrews, 2000, The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew, Br. J. Pharmacol., 130, 1247, 10.1038/sj.bjp.0703428 Angel, 1993, Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties, Eur. J. Pharmacol., 232, 139, 10.1016/0014-2999(93)90767-C Bailey, 1995, The 5-HT3 receptor antagonist ondansetron reduces gastrointestinal side effects induced by specific serotonin re-uptake inhibitor in man, J. Psychopharmacol., 204, 273 Barnes, 1988, Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret, Neuropharmacology, 27, 783, 10.1016/0028-3908(88)90092-5 Barnes, 1999, A review of central 5-HT receptors and their function, Neuropharmacology, 38, 1083, 10.1016/S0028-3908(99)00010-6 Barrett, 1992, Discriminative stimulus effects of 8-OH-DPAT in pigeons: antagonism studies with the putative 5-HT1A receptor antagonists BMY 7378 and NAN-190, Eur. J. Pharmacol., 217, 163, 10.1016/0014-2999(92)90841-Q Beleslin, 1986, Dimethylphenylpiperazinium-induced vomiting: nicotinic mediation in area postrema, Brain Res. Bull., 16, 5, 10.1016/0361-9230(86)90004-3 Beleslin, 1987, Further studies on nicotine-induced emesis: nicotinic mediation in area postrema, Physiol. Behav., 39, 681, 10.1016/0031-9384(87)90250-2 Beleslin, 1987, Noradrenaline-induced emesis. Alpha-2 adrenoceptor mediation in the area postrema, Neuropharmacology, 26, 1157, 10.1016/0028-3908(87)90262-0 Beleslin, 1989, Area postrema: cholinergic and noradrenergic regulation of emesis. A new concept, Arch. Int. Physiol. Biochim., 97, 107, 10.3109/13813458909075054 Bertrand, 2010, Serotonin release and uptake in the gastrointestinal tract, Auton. Neuroscie.: Basic Clin., 153, 47, 10.1016/j.autneu.2009.08.002 Bhandari, 1991, Preliminary evidence for the involvement of the putative 5-HT4 receptor in zacopride- and copper sulfate-induced vomiting in the ferret, Eur. J. Pharmacol., 204, 273, 10.1016/0014-2999(91)90852-H Birdsall, 1998, 5-Hydroxytryptophan: a clinically-effective serotonin precursor, Altern. Med. Rev., 3, 271 Boess, 1998, The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum, Mol. Pharmacol., 54, 577, 10.1124/mol.54.3.577 Bogdanski, 1958, Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan, J. Pharmacol. Exp. Ther., 122, 182 Bolognini, 2013, Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behavior in rats by enhancing 5-HT(1A) receptor activation, Br. J. Pharmacol., 168, 1456, 10.1111/bph.12043 Boyd, 1957, Agents affecting apomorphine-induced vomiting, J. Pharmacol. Exp. Ther., 119, 390 Byerley, 1987, 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects, J. Clin. Psychopharmacol., 7, 127, 10.1097/00004714-198706000-00002 Cahen, 1964, On the mechanism of Emesis induced by 5-Hydroxytryptamine, Proc. Soc. Exp. Biol. Med., 116, 402, 10.3181/00379727-116-29260 Cahen, 1970, Emetic effect of biogenic amines, Res. Clin. Stud. Headache, 3, 227 Campos, 1987, Rats and marmosets respond differently to serotonin agonists and antagonists, Psychopharmacology, 92, 478, 10.1007/BF00176482 Chen, 1997, Ethanol-induced emesis in the house musk shrew, Suncus murinus. Life Sci., 60, 253, 10.1016/S0024-3205(96)00625-X Chung, 1991, Safety of L-tryptophan for pigs, J. Anim. Sci., 69, 2955, 10.2527/1991.6972955x Clineschmidt, 1977, Anorexigenic and ancillary actions of MK-212 (6-chloro-2-(1-piperazinyl)-pyrazine; CPP), Psychopharmacology (Berlin), 55, 27, 10.1007/BF00432813 Coda, 1993, Enhancement of morphine analgesia by fenfluramine in subjects receiving tailored opioid infusions, Pain, 52, 85, 10.1016/0304-3959(93)90118-9 Cohen, 1989, Comparison of the 5-HT3 receptor antagonist properties of ICS 205-930, GR38032F and zacopride, J. Pharmacol. Exp. Ther., 248, 197 Cook-Sather, 2002, Cisapride does not prevent postoperative vomiting in children, Anesth. Analg., 94, 50, 10.1213/00000539-200201000-00009 Coronas, 1975, Blockade of reserpine emesis in pigeons by metoclopramide, Eur. J. Pharmacol., 32, 380, 10.1016/0014-2999(75)90309-X Costall, 1990, Fluphenazine, ICS 205-930 and dl-fenfluramine differentially antagonise drug-induced emesis in the ferret, Neuropharmacology, 29, 453, 10.1016/0028-3908(90)90167-P Costall, 1987, Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs, Neuropharmacology, 26, 1321, 10.1016/0028-3908(87)90094-3 Costall, 1990, The actions of fenfluramine and interaction with 5-HT3 receptor-antagonists to inhibit emesis in the ferret, J. Pharm. Pharmacol., 42, 94, 10.1111/j.2042-7158.1990.tb05361.x Darmani, 1998, Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis, J. Neural. Transm., 105, 1143, 10.1007/s007020050118 Darmani, 2004, Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis, Eur. J. Pharmacol., 488, 201, 10.1016/j.ejphar.2004.02.018 Darmani, 2011, Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykinergic NK1receptor antagonists in the least shrew (Cryptosis parva), Pharmacol. Biochem. Behav., 99, 573, 10.1016/j.pbb.2011.05.025 Delagrange, 1996, Interaction of S 21007 with 5-HT3 receptors. In vitro and in vivo characterization, Eur. J. Pharmacol., 316, 195, 10.1016/S0014-2999(96)00680-2 Deruyttere, 1987, Cisapride in the management of chronic functional dyspepsia: a multicenter, double-blind, placebo-controlled study, Clin. Ther., 10, 44 Dhawan, 1961, Antiemetic activity of D-lysergic acid diethylamide, J. Pharmacol. Exp. Ther., 133, 137 Di Francesco, 1988, Antihypertensive effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in conscious dogs, Eur. J. Pharmacol., 147, 287, 10.1016/0014-2999(88)90789-3 Diener, 2001, Advances in pharmacological treatment of migraine, Expert. Opin. Investig. Drugs, 10, 1831, 10.1517/13543784.10.10.1831 Domenech, 1997, Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist, Naunyn Schmiedebergs Arch. Pharmacol., 356, 328, 10.1007/PL00005058 Earl, 1955, Assay of reserpine based on emesis in pigeons, J. Pharmacol. Exp. Ther., 115, 55 Feighner, 1989, Serotonin-1A anxiolytics: an overview, Psychopathology, 22, 21, 10.1159/000284623 Feldberg, 1953, Intraventricular injections of acetylcholine and of 5-hydroxytryptamine (serotonin) into the conscious cat, J. Physiol., 120, 12 pp Foong, 2009, 5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig, Neuroreport, 20, 325, 10.1097/WNR.0b013e3283232caa Forbes, 1995, Cyclical vomiting syndrome, J. Paediatr. Child Health, 31, 67, 10.1111/j.1440-1754.1995.tb00748.x Foreman, 1993, Preclinical studies on LY228729: a potent and selective serotonin1A agonist, J. Pharmacol. Exp. Ther., 267, 58 Foulkes, 1997, Rhythmic transcription: the molecular basis of circadian melatonin synthesis, Trends Neurosci., 20, 487, 10.1016/S0166-2236(97)01109-0 Freeman, 1992, Selectivity of 5-HT3 receptor antagonists and anti-emetic mechanisms of action, Anticancer Drugs, 3, 79, 10.1097/00001813-199204000-00001 Fujiwara-Sawada, 2003, Possible involvement of peripheral serotonin 5-HT3 receptors in fluvoxamine-induced emesis in Suncus murinus, J. Pharm. Pharmacol., 55, 271, 10.1211/002235702496 Fujiwara-Sawada, 2000, Emetic reaction induced by a selective serotonin reuptake inhibitor, fluvoxamine, in Suncus murinus, Pharmacometrics, 59, 39 Ganesan, 2010, Protracted cisplatin-induced vomiting responding to mosapride, Indian J. Cancer, 47, 73, 10.4103/0019-509X.58866 Gershon, 1980, Effects of indolic neurotoxins on enteric serotonergic neurons, J. Comp. Neurol., 190, 581, 10.1002/cne.901900311 Gijsman, 2002, Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers, J. Clin. Psychopharmacol., 22, 183, 10.1097/00004714-200204000-00012 Gralla, 1983, Metoclopramide. A review of antiemetic trials, Drugs, 25, 63, 10.2165/00003495-198300251-00007 Gralla, 1981, Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting, N. Engl. J. Med., 305, 905, 10.1056/NEJM198110153051601 Greer, 2005, A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine, J. Neurobiol., 64, 239, 10.1002/neu.20146 Greist, 2004, Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetine, Clin. Ther., 26, 1446, 10.1016/j.clinthera.2004.09.010 Gullikson, 1991, Relationship of serotonin-3 receptor antagonist activity to gastric emptying and motor-stimulating actions of prokinetic drugs in dogs, J. Pharmacol. Exp. Ther., 258, 103 Gupta, 2002, Involvement of 5-HT1A and 5-HT2 receptor in cisplatin induced emesis in dogs, Indian J. Physiol. Pharmacol., 46, 463 Gylys, 1979, Antagonism of cisplatin induced emesis in the dog, Res. Commun. Chem. Pathol. Pharmacol., 23, 61 Hamblin, 1991, Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor, Mol. Pharmacol., 40, 143 Hattori, 2010, The nucleus raphe magnus suppresses vomiting, and the solitary nucleus and 5-HT are not involved in this suppression, Auton. Neurosci., 152, 41, 10.1016/j.autneu.2009.08.021 Higgins, 1989, 5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret, Br. J. Pharmacol., 97, 247, 10.1111/j.1476-5381.1989.tb11948.x Hikasa, 1992, Central alpha-adrenoceptor subtypes involved in the emetic pathway in cats, Eur. J. Pharmacol., 229, 241, 10.1016/0014-2999(92)90562-I Holschneider, 2001, Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B, Brain Res. Bull., 56, 453, 10.1016/S0361-9230(01)00613-X Horikoshi, 2001, Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisplatin in Suncus murinus, Jpn. J. Pharmacol., 85, 70, 10.1254/jjp.85.70 Hoyer, 2002, Molecular, pharmacological and functional diversity of 5-HT receptors, Pharmacol. Biochem. Behav., 71, 533, 10.1016/S0091-3057(01)00746-8 Ito, 1995, The anti-emetic activity of GK-128 in Suncus murinus, Eur. J. Pharmacol., 285, 37, 10.1016/0014-2999(95)00372-R Japundzic-Zigon, 1997, Clonidine-induced emesis: a multitransmitter pathway concept, Pharmacol. Res., 35, 287, 10.1006/phrs.1997.0133 Javid, 2002, The effect of serotonin and serotonin receptor antagonists on motion sickness in Suncus murinus, Pharmacol. Biochem. Behav., 73, 979, 10.1016/S0091-3057(02)00955-3 Javid, 2006, The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus, Pharmacol. Biochem. Behav., 85, 820, 10.1016/j.pbb.2006.11.018 Jian, 1985, Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride), Gut, 26, 352, 10.1136/gut.26.4.352 Johannes, 1999, Influence of sodium butyrate on the induction of radiation-induced chromosomal aberrations and sister chromatid exchanges in Chinese hamster ovary (CHO) cells, Mutat. Res., 429, 141, 10.1016/S0027-5107(99)00106-2 Jovanovic-Micic, 1995, The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis, Eur. J. Pharmacol., 272, 21, 10.1016/0014-2999(94)00622-E Kaiser, 2004, Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists, Pharmacogenetics, 14, 271, 10.1097/00008571-200405000-00001 Kamato, 1993, Mechanisms of cisplatin- and m-chlorophenylbiguanide-induced emesis in ferrets, Eur. J. Pharmacol., 238, 369, 10.1016/0014-2999(93)90868-I Kan, 2003, Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew), Eur. J. Pharmacol., 482, 297, 10.1016/j.ejphar.2003.09.069 Kato, 2006, Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients, Neuropsychobiology, 53, 186, 10.1159/000094727 Kaube, 1993, Inhibition by sumatriptan of central trigeminal neurones only after blood-brain barrier disruption, Br. J. Pharmacol., 109, 788, 10.1111/j.1476-5381.1993.tb13643.x Khandker, 1994, Modification of reserpine-induced emetic response in pigeons by alpha 2-adrenoceptors, Pharmacol. Res., 29, 383, 10.1016/1043-6618(94)80060-X Kilpatric, 1993, 5-HT3 receptors, 179 King, 1990, Emesis and defecations induced by the 5-hydroxytryptamine (5-HT3) receptor antagonist zacopride in the ferret, J. Pharmacol .Exp. Ther., 253, 1034 King, 1990, Effects of zacopride and BMY25801 (batanopride) on radiation-induced emesis and locomotor behavior in the ferret, J. Pharmacol. Exp. Ther., 253, 1026 Klein, 1968, Antiemetic effect of metoclopramide evaluation in humans, Anesth. Analg., 47, 259, 10.1213/00000539-196805000-00012 Knight, 2004, Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors, Naunyn Schmiedebergs Arch. Pharmacol., 370, 114, 10.1007/s00210-004-0951-4 Knox, 1993, Behavioral studies of emetic sensitivity in the ferret, Brain Res. Bull., 31, 477, 10.1016/0361-9230(93)90112-O Kranke, 2012, Intravenous buspirone for the prevention of postoperative nausea and vomiting, Eur. J. Clin. Pharmacol., 68, 1465, 10.1007/s00228-012-1284-8 Lance, 1991, 5-Hydroxytryptamine and its role in migraine, Eur. Neurol., 31, 279, 10.1159/000116754 Lang, 1989, Functional localization of specific receptors mediating gastrointestinal motor correlates of vomiting, Am. J. Physiol., 256, G92 Lee, 2012, The management of cyclic vomiting syndrome: a systematic review, Eur. J. Gastroenterol. Hepatol., 24, 1001, 10.1097/MEG.0b013e328355638f Li Kam, 1993, A comparison of the effects of two putative 5-hydroxytryptamine renal prodrugs in normal man, Br. J. Clin. Pharmacol., 36, 19, 10.1111/j.1365-2125.1993.tb05886.x Lucot, 1990, Effects of serotonin antagonists on motion sickness and its suppression by 8-OH-DPAT in cats, Pharmacol. Biochem. Behav., 37, 283, 10.1016/0091-3057(90)90335-F Lucot, 1990, RU 24969-induced emesis in the cat: 5-HT1 sites other than 5-HT1A, 5-HT1B or 5-HT1C implicated, Eur. J. Pharmacol., 180, 193, 10.1016/0014-2999(90)90302-M Lucot, 1994, Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin, Eur. J. Pharmacol., 253, 53, 10.1016/0014-2999(94)90756-0 Lucot, 1987, Buspirone blocks cisplatin-induced emesis in cats, J. Clin. Pharmacol., 27, 817, 10.1002/j.1552-4604.1987.tb03003.x Lucot, 1987, Buspirone blocks motion sickness and xylazine-induced emesis in the cat, Aviat. Space Environ. Med., 58, 989 Lucot, 1989, 8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine, Pharmacol. Biochem. Behav., 33, 627, 10.1016/0091-3057(89)90399-7 Lutsep, 2005, Repinotan, A 5-HT1A agonist, in the treatment of acute ischemic stroke, Curr. Drug Targets CNS Neurol. Disord., 4, 119, 10.2174/1568007053544165 Ma, 2013, Polymorphisms of the HTR3B gene are associated with post-surgery emesis in a Chinese Han population, J. Clin. Pharm. Ther., 38, 150, 10.1111/jcpt.12033 Maisano, 2001, Cisapride and dexamethasone in the prevention of delayed emesis after cisplatin administration, Support Care Cancer, 9, 61, 10.1007/s005200000156 Marcus, 2006, Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study, Med. Sci. Monit.: International Med. J. Exp. Clin. Res., 12, PI1 Marona-Lewicka, 2009, WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation, Behav. Pharmacol., 20, 114, 10.1097/FBP.0b013e3283242f1a Maroteaux, 1992, Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers, Proc. Natl. Acad. Sci. USA, 89, 3020, 10.1073/pnas.89.7.3020 Marston, 2009, Targeting the serotonin 2C receptor for the treatment of obesity and type 2 diabetes, Neuropsychopharmacology., 34, 252, 10.1038/npp.2008.169 Matsuki, 1997, Male/female differences in drug-induced emesis and motion sickness in Suncus murinus, Pharmacol. Biochem. Behav., 57, 721, 10.1016/S0091-3057(96)00389-9 Middlefell, 1991, 5-HT3 receptor agonism may be responsible for the emetic effects of zacopride in the ferret, Br. J. Pharmacol., 103, 1011, 10.1111/j.1476-5381.1991.tb12292.x Milano, 1990, Vagal-induced vomiting in decerebrate cat is not suppressed by specific 5-HT3 receptor antagonists, J. Auton. Nerv. Syst., 31, 109, 10.1016/0165-1838(90)90067-S Miller, 1992, Mechanisms of vomiting induced by serotonin-3 receptor agonists in the cat: effect of vagotomy, splanchnicectomy or area postrema lesion, J. Pharmacol. Exp. Ther., 260, 509 Mine, 2013, Anti-emetic effect of mosapride citrate hydrate, a 5-HT4 receptor agonist, on selective serotonin reuptake inhibitors (SSRIs)-induced emesis in experimental animals, J. Pharmacol. Sci., 121, 58, 10.1254/jphs.12175FP Murphy, 2003, Pharmacogenetics of antidepressant medication intolerance, Am. J. Psychiatry, 160, 1830, 10.1176/appi.ajp.160.10.1830 Nakayama, 2005, Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets, J. Pharmacol. Sci., 98, 396, 10.1254/jphs.FPJ05001X Nalotov, 1994, Correlation of dopamine and serotoninergic components in the neurochemical organization of the emetic mechanism, Fiziol. Zh., 40, 10 Navarra, 1992, A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon, Toxicol. Lett., 745, 10.1016/0378-4274(92)90256-J Newman-Tancredi, 1998, Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study, Eur. J. Pharmacol., 355, 245, 10.1016/S0014-2999(98)00483-X Nichols, 2002, Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD), J. Med. Chem., 45, 4344, 10.1021/jm020153s Oertel, 2007, The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans, Clin. Pharmacol. Ther., 81, 59, 10.1038/sj.clpt.6100018 Okada, 1995, Blockade of motion- and cisplatin-induced emesis by a 5-HT2 receptor agonist in Suncus murinus, Br. J. Pharmacol., 114, 931, 10.1111/j.1476-5381.1995.tb13293.x Okada, 1996, Prophylactic effect of serotonin uptake inhibitors against motion sickness in Suncus murinus, Eur. J. Pharmacol., 309, 33, 10.1016/0014-2999(96)00407-4 Okada, 1994, Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus, Jpn. J. Pharmacol., 64, 109, 10.1254/jjp.64.109 Pacher, 2001, Current trends in the development of new antidepressants, Curr. Med. Chem., 8, 89, 10.2174/0929867013373796 Patel, 2013, Sensory neuromodulators in functional nausea and vomiting: predictors of response, Postgrad. Med. J., 89, 131, 10.1136/postgradmedj-2012-131284 Perkel, 1980, Metoclopramide therapy in fifty-five patients with delayed gastric emptying, Am. J. Gastroenterol., 74, 231 Perry, 1998, Sumatriptan. An updated review of its use in migraine, Drugs, 55, 889, 10.2165/00003495-199855060-00020 Pinder, 1975, Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity, Drugs, 10, 241, 10.2165/00003495-197510040-00001 Pinder, 1976, Metoclopramide: a review of its pharmacological properties and clinical use, Drugs, 12, 81, 10.2165/00003495-197612020-00001 Pisters, 1992, Dose-ranging trial of zacopride: the emetic antiemetic?, J. Natl. Cancer Inst., 84, 717, 10.1093/jnci/84.9.717 Preziosi, 1992, The effects of 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon, Eur. J. Pharmacol., 221, 343, 10.1016/0014-2999(92)90721-F Price, 1985, Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients, Life Sci., 37, 809, 10.1016/0024-3205(85)90515-6 Ravenscroft, 1992, Agonist evidence for the involvement of 5-HT3 receptors in emesis in the ferret, 251 Robichaud, 2001, PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway, Neuropharmacology, 40, 262, 10.1016/S0028-3908(00)00142-8 Rock, 2012, Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behavior via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus, Br. J. Pharmacol., 165, 2620, 10.1111/j.1476-5381.2011.01621.x Rojas, 2012, Pharmacological mechanisms of 5-HT(3) and tachykinin NK(1) receptor antagonism to prevent chemotherapy-induced nausea and vomiting, Eur. J. Pharmacol., 684, 1, 10.1016/j.ejphar.2012.01.046 Rojas, 2008, Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor, Anesth. Analg., 107, 469, 10.1213/ane.0b013e318172fa74 Rothman, 2002, Serotonin releasing agents. Neurochemical, therapeutic and adverse effects, Pharmacol. Biochem. Behav., 71, 825, 10.1016/S0091-3057(01)00669-4 Rothman, 2000, Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications, Circulation, 102, 2836, 10.1161/01.CIR.102.23.2836 Rothman, 2003, (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters, J. Pharmacol. Exp. Ther., 305, 1191, 10.1124/jpet.103.049684 Rudd, 2004, Mechanisms of acute, delayed and anticipatory vomiting in cancer and cancer treatment, 15 Rudd, 1998, Serotonin-independent model of cisplatin-induced emesis in the ferret, Jpn. J. Pharmacol., 78, 253, 10.1254/jjp.78.253 Rudd, 1999, Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew), Eur. J. Pharmacol., 374, 77, 10.1016/S0014-2999(99)00285-X Rudd, 1994, Modulation of emesis by 5-HT1A receptors, Pathophysiol.: Official J. Int. Soc. Pathophysiol./ISP, 1, 267, 10.1016/0928-4680(94)90009-4 Rueffert, 2009, Do variations in the 5-HT3A and 5-HT3B serotonin receptor genes (HTR3A and HTR3B) influence the occurrence of postoperative vomiting?, Anesth. Analg., 109, 1442, 10.1213/ane.0b013e3181b2359b Sam, 2003, Action of 5-HT3 receptor antagonists and dexamethasone to modify cisplatin-induced emesis in Suncus murinus (house musk shrew), Eur. J. Pharmacol., 472, 135, 10.1016/S0014-2999(03)01863-6 Sancilio, 1990, Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents, Eur. J. Pharmacol., 181, 303, 10.1016/0014-2999(90)90094-M Sanger, 1988, From metoclopramide to selective gut motility stimulants and 5-HT3 receptor antagonists, Drug Des. Deliv., 3, 273 Schiwy, 1989, Therapeutic and side-effect profile of a selective and reversible MAO-A inhibitor, brofaromine. Results of dose-finding trials in depressed patients, J. Neural. Transm. Suppl., 28, 33 Sharon, 1972, Hematemesis after reserpine for Raynaud's phenomenon, Ann. Intern. Med., 77, 479, 10.7326/0003-4819-77-3-479 Shen, 1993, Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype, J. Biol. Chem., 268, 18200, 10.1016/S0021-9258(17)46830-X Shupak, 2006, Motion sickness: advances in pathogenesis, prediction, prevention, and treatment, Aviat. Space Environ. Med., 77, 1213 Smarius, 2008, Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa, J Psychopharmacol, 10.1177/0269881107082025 Smith, 1989, The antiemetic profile of zacopride, J. Pharm. Pharmacol., 41, 101, 10.1111/j.2042-7158.1989.tb06402.x Stanford, 1996, Prozac: panacea or puzzle?, Trends Pharmacol. Sci., 17, 150, 10.1016/0165-6147(96)81591-4 Sugai, 2006, The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine, Pharmacogenom. J., 6, 351, 10.1038/sj.tpj.6500382 Suzuki, 2006, Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in Japanese depressed patients, Neuropsychopharmacology, 31, 825, 10.1038/sj.npp.1300919 Talley, 1992, Review article: 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: clinical implications, Aliment. Pharmacol. Ther., 6, 273, 10.1111/j.1365-2036.1992.tb00050.x Tanaka, 2008, Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea, Int. J. Neuropsychopharmacol., 11, 261, 10.1017/S1461145707007985 Tandon, 1969, Effect of reserpine injections in migrainous and normal control subjects, with estimations of urinary 5-hydroxyindoleacetic acid, Neurology, 19, 1073, 10.1212/WNL.19.11.1073 Tanihata, 2000, Cisplatin-induced early and delayed emesis in the pigeon, Br. J. Pharmacol., 130, 132, 10.1038/sj.bjp.0703283 Thomas, 2009, Pharmacogenetics of selective serotonin reuptake inhibitors and associated adverse drug reactions, Pharmacotherapy, 29, 822, 10.1592/phco.29.7.822 Thompson, 2013, Recent developments in 5-HT3 receptor pharmacology, Trends Pharmacol. Sci., 34, 100, 10.1016/j.tips.2012.12.002 Tonini, 1995, Therapeutic potential of drugs with mixed 5-HT4 agonist/5-HT3 antagonist action in the control of emesis, Pharmacol. Res., 31, 257, 10.1016/1043-6618(95)80029-8 Torii, 1991, 5-Hydroxytryptamine is emetogenic in the house musk shrew, Suncus murinus, Naunyn Schmiedebergs Arch. Pharmacol., 344, 564, 10.1007/BF00170653 Torii, 1991, Selective blockade of cytotoxic drug-induced emesis by 5-HT3 receptor antagonists in Suncus murinus, Jpn. J. Pharmacol., 55, 107, 10.1254/jjp.55.107 Tremblay, 2003, Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients, J. Clin. Oncol., 21, 2147, 10.1200/JCO.2003.05.164 Trivedi, 1973, Modification of neuropharmacological actions of some drugs by biogenic amine altering agents, Indian J. Physiol. Pharmacol., 17, 47 Tsukamoto, 2012, Effect of mosapride on prednisolone-induced gastric mucosal injury and gastric-emptying disorder in dog, J. Vet. Med. Sci., 74, 1103, 10.1292/jvms.12-0066 Twissell, 1994, 5-HT4 receptors are not involved in the emetic response to cisplatin, copper sulfate and R,S-zacopride in the ferret, Br. J. Pharmacol., 113, 22 Ueda, 2003, Higher plasma 5-hydroxyindoleacetic acid levels are associated with SSRI-induced nausea, Neuropsychobiology, 48, 31, 10.1159/000071826 Ueda, 2001, Characteristics of fluvoxamine-induced nausea, Psychiatry. Res., 104, 259, 10.1016/S0165-1781(01)00320-1 Vallotton, 2001, In vitro and in vivo ligand binding to the 5HT(3) serotonin receptor characterised by time-resolved fluorescence spectroscopy, Chembiochem: Eur. J. Chem. Biol., 2, 205, 10.1002/1439-7633(20010302)2:3<205::AID-CBIC205>3.0.CO;2-J van Vliet, 1996, Behavioral, neuroendocrine and biochemical effects of different doses of 5-HTP in panic disorder, Eur. Neuropsychopharmacol., 6, 103, 10.1016/0924-977X(95)00070-6 Van Woert, 1976, Serotonin and myoclonus, Monogr. Neural. Sci., 3, 71 Walstab, 2008, Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors, Pharmacogenet. Genomics, 18, 793, 10.1097/FPC.0b013e3283050117 Warneck, 2008, Action of (R)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret, Toxicol. Appl. Pharmacol., 232, 369, 10.1016/j.taap.2008.07.003 Wauquier, 1981, Neuropharmacological comparison between domperidone and metoclopramide, Jpn. J. Pharmacol., 31, 305, 10.1254/jjp.31.305 Winans, 2003, Aripiprazole, Am. J. Health Syst. Pharm., 60, 2437, 10.1093/ajhp/60.23.2437 Winner, 2007, Twelve-month tolerability and safety of sumatriptan-naproxen sodium for the treatment of acute migraine, Mayo Clin. Proc., 82, 61, 10.1016/S0025-6196(11)60968-3 Wolff, 1994, Antiemetic effects of 5-HT1A agonists in the pigeon, Pharmacol. Biochem. Behav., 49, 385, 10.1016/0091-3057(94)90438-3 Wolff, 1995, Comparison of the antiemetic effects of a 5-HT1A agonist, LY228729, and 5-HT3 antagonists in the pigeon, Pharmacol. Biochem. Behav., 52, 571, 10.1016/0091-3057(95)00142-J Wolff, 2000, A comparison of the behavioural effects of 5-HT2A and 5-HT2C receptor agonists in the pigeon, Behav. Pharmacol., 11, 355, 10.1097/00008877-200008000-00001 Xiong, 2008, Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization, Mol. Pharmacol., 73, 314, 10.1124/mol.107.039149 Yamakuni, 2006, Inhibitory effect of zacopride on Cisplatin-induced delayed emesis in ferrets, J. Pharmacol. Sci., 101, 99, 10.1254/jphs.SCJ05007X Yamakuni, 2000, Probable involvement of the 5-hydroxytryptamine(4) receptor in methotrexate-induced delayed emesis in dogs, J. Pharmacol. Exp. Ther., 292, 1002 Yoshida, 2003, Monoamine oxidase A gene polymorphism, 5-HT 2A receptor gene polymorphism and incidence of nausea induced by fluvoxamine, Neuropsychobiology, 48, 10, 10.1159/000071822 Yoshio, 2001, Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes, Jpn. J. Pharmacol., 86, 189, 10.1254/jjp.86.189