Longitudinal body composition of children born to mothers with normal weight, overweight, and obesity

Obesity - Tập 23 Số 6 - Trang 1252-1258 - 2015
Aline Andres1,2, Holly R. Hull3, Kartik Shankar1,2, Patrick H. Casey2, Mario A. Cleves1,2, Thomas M. Badger1,2
1Arkansas Children's Nutrition Center, Little Rock, Arkansas, USA
2Department of Pediatrics, University of Arkansas for Medical Sciences Little Rock, Arkansas, USA
3School of Health Professions, University of Kansas Medical Center, Kansas City, Kansas, USA

Tóm tắt

ObjectiveThe longitudinal trajectories of body composition of children born to mothers with normal weight, overweight, and obesity have not been evaluated using precise body composition methods. This study investigated the relationship between maternal prepregnancy BMI and offspring body composition trajectories during the first 6 years of life.MethodsHealthy infants (N = 325) were assessed longitudinally (at ages 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, and 6 years) using dual‐energy X‐ray absorptiometry. Mixed‐effects regression for repeated measures was used to model each continuous outcome as a function of maternal BMI and covariates (race, gestational age, birth weight, and mode of infant feeding).ResultsMaternal obesity differentially impacted body fat, but not bone mineral content or density, of girls and boys. Boys born to mothers with obesity have higher body fat from ages 2–6 years compared to boys born to normal‐weight and overweight mothers (P < 0.05), whereas body composition of girls born to mothers with obesity was not different across groups during the first 6 years of life (P > 0.05).ConclusionsThis clinical observational study demonstrates a sexual dimorphism in offspring body composition until age 6 years based on maternal BMI, with a greater effect of maternal adiposity seen in boys than in girls.

Từ khóa


Tài liệu tham khảo

10.1001/jama.2014.732

10.1016/j.ajog.2007.10.796

10.1016/j.ajog.2011.04.004

10.1016/j.ajog.2006.06.014

10.1111/apa.12713

10.1002/oby.20236

10.3945/ajcn.2009.29128

Hull HR, 2014, Maternal obesity influences the relationship between location of neonate fat mass and total fat mass, Pediatr Obes

10.1016/j.jpeds.2014.05.050

10.1210/jc.2010-0697

10.1002/oby.20742

10.1152/ajpregu.00316.2007

August BH, 1975, Four Factor Index of Social Status

Grummer‐Strawn LM, 2010, Use of World Health Organization and CDC growth charts for children aged 0–59 months in the United States, MMWR Recomm Rep, 59, 1

Rabe‐Hesketh SSA, 2008, Multilevel and Longitudinal Modeling Using Stata

10.1093/biomet/73.3.751

10.1093/ajcn/58.6.839

10.1038/sj.ejcn.1600448

10.1111/j.1749-6632.2000.tb06487.x

10.1152/jappl.2000.89.2.613

10.1111/j.1749-6632.2000.tb06423.x

10.1152/japplphysiol.00377.2003

10.1542/peds.113.5.1285

10.1093/ajcn/85.6.1578

10.1007/s00247-006-0153-y

10.1016/j.jocd.2014.01.002

10.1210/jc.2007-0088

10.1016/j.jpeds.2010.08.008

Pereira‐da‐Silva L, 2014, The adjusted effect of maternal body mass index, energy and macronutrient intakes during pregnancy, and gestational weight gain on body composition of full‐term neonates, Am J Perinatol, 31, 875

10.1002/oby.20236

10.1016/j.earlhumdev.2013.07.028

10.1001/archpedi.160.5.513

10.2337/dc08-2077

10.1038/ijo.2010.149

10.3389/fgene.2011.00027

10.1016/j.placenta.2013.03.009

10.1016/j.placenta.2014.03.010

10.1152/ajpendo.00076.2013

10.1002/em.21827

10.1096/fj.11-197822

Thông tin
Thông tin xuất bản

Obesity

Tập 23 Số 6

1252-1258

Thông tin tác giả