Longitudinal Assessment of Motor Recovery of Contralateral Hand after Basal Ganglia Infarction Using Functional Magnetic Resonance Imaging

BioMed Research International - Tập 2016 - Trang 1-9 - 2016
Yue Fu1, Quan Zhang1, Chunshui Yu1, Jing Zhang1, Ning Wang1, Shanhuai Zuo1, Ningnannan Zhang1
1Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China

Tóm tắt

We used functional fMRI to study the brain activation during active finger movements at different time points during the recovery phase following basal ganglia infarction. Four hemiplegic patients with basal ganglia infarction were serially evaluated at different time points spanning the acute and chronic phase using fMRI. To evaluate motor recovery, the patients were asked to perform functional tasks arranged in a block design manner with their hand. On follow-up (chronic phase), three patients achieved significant recovery of motor function of affected limbs. Activation of bilateral sensorimotor cortex (SMC) was observed in two of these patients, while activation of cerebellum was observed in all patients. No remarkable recovery of motor function was noted in one patient with left basal ganglia infarction. In this patient, the activation domain was located in SMC of both sides in acute phase and in ipsilateral SMC in chronic phase. Contralateral SMC appears to be involved in the functional rehabilitation following basal ganglia infarction. The cerebellum may act as an intermediary during functional recovery following basal ganglia infarction. The activation domain associated with active finger movement may be bilateral in acute phase; one patient was ipsilateral in the chronic stage.

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Tài liệu tham khảo

10.1159/000366099

10.1007/s00422-010-0401-y

10.1007/s12013-015-0608-6

10.1159/000286342

10.1001/archneur.60.3.351

10.1002/hbm.22711

10.1523/JNEUROSCI.2659-14.2015

10.1016/j.neuroimage.2011.09.058

10.1212/01.wnl.0000225178.85833.0d

10.1177/154596802401105216

10.1097/01.wnn.0000209875.56060.06

10.3233/NRE-2010-0549

10.1016/j.apmr.2004.11.043

10.1001/archneur.62.5.809

2001, Journal of Neuroscience, 21, 5272, 10.1523/JNEUROSCI.21-14-05272.2001

10.1093/brain/awf183

10.1073/pnas.231235598

10.1093/brain/awf148

10.1161/01.STR.31.3.656

10.1016/j.neuroimage.2004.07.058

10.1161/01.str.0000017100.68294.52

10.1007/s00234-013-1188-z

10.1093/brain/awg145

10.1007/bf00230980

10.1001/archneur.55.8.1081

10.1161/01.str.28.12.2518

10.1006/nimg.1996.0034

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BioMed Research International

Tập 2016

1-9

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