Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture

Allsopp, 1992, Telomere length predicts replicative capacity of human fibroblasts, Proc. Natl. Acad. Sci. U. S. A., 89, 10114, 10.1073/pnas.89.21.10114

Andrews, 1984, Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro, Dev. Biol., 103, 285, 10.1016/0012-1606(84)90316-6

Blelloch, 2006, Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus, Stem Cells, 24, 2007, 10.1634/stemcells.2006-0050

Bonni, 1997, Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway, Science, 278, 477, 10.1126/science.278.5337.477

Carpenter, 1999, In vitro expansion of a multipotent population of human neural progenitor cells, Exp. Neurol., 158, 265, 10.1006/exnr.1999.7098

Ciccolini, 1998, Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2, J. Neurosci., 18, 7869, 10.1523/JNEUROSCI.18-19-07869.1998

Colognato, 2005, Human diseases reveal novel roles for neural laminins, Trends Neurosci., 28, 480, 10.1016/j.tins.2005.07.004

Conti, 2005, Niche-independent symmetrical self-renewal of a mammalian tissue stem cell, PLoS Biol., 3, e283, 10.1371/journal.pbio.0030283

De Filippis, 2007, A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes, Stem Cells, 25, 2312, 10.1634/stemcells.2007-0040

Flax, 1998, Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes, Nat. Biotechnol., 16, 1033, 10.1038/3473

Glaser, 2007, Tripotential differentiation of adherently expandable neural stem (NS) cells, PLoS ONE, 2, e298, 10.1371/journal.pone.0000298

Hodes, 1999, Telomere length, aging, and somatic cell turnover, J. Exp. Med., 190, 153, 10.1084/jem.190.2.153

Liesi, 1985, Do neurons in the vertebrate CNS migrate on laminin?, EMBO J., 4, 1163, 10.1002/j.1460-2075.1985.tb03755.x

Lowell, 2006, Notch promotes neural lineage entry by pluripotent embryonic stem cells, PLoS Biol., 4, e121, 10.1371/journal.pbio.0040121

Malatesta, 2000, Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage, Development, 127, 5253, 10.1242/dev.127.24.5253

Mercier, 2002, Anatomy of the brain neurogenic zones revisited: fractones and the fibroblast/macrophage network, J. Comp. Neurol., 451, 170, 10.1002/cne.10342

Merkle, 2004, Radial glia give rise to adult neural stem cells in the subventricular zone, Proc. Natl. Acad. Sci. U. S. A., 101, 17528, 10.1073/pnas.0407893101

Nakashima, 1999, Astrocyte differentiation mediated by LIF in cooperation with BMP2, FEBS Lett., 457, 43, 10.1016/S0014-5793(99)00997-7

Noctor, 2001, Neurons derived from radial glial cells establish radial units in neocortex, Nature, 409, 714, 10.1038/35055553

Ostenfeld, 2000, Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation, Exp. Neurol., 164, 215, 10.1006/exnr.2000.7427

Palmer, 2001, Cell culture. Progenitor cells from human brain after death, Nature, 411, 42, 10.1038/35075141

Pleasure, 1992, Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons, J. Neurosci., 12, 1802, 10.1523/JNEUROSCI.12-05-01802.1992

Pollard, 2006, Neural stem cells, neurons, and glia, Methods Enzymol., 418, 151, 10.1016/S0076-6879(06)18010-6

Pollard, 2006, Adherent neural stem (NS) cells from fetal and adult forebrain, Cereb. Cortex, 16, i112, 10.1093/cercor/bhj167

Rakic, 2003, Elusive radial glial cells: historical and evolutionary perspective, Glia, 43, 19, 10.1002/glia.10244

Reynolds, 1992, Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system, Science, 255, 1707, 10.1126/science.1553558

Reynolds, 2005, Neural stem cells and neurospheres—re-evaluating the relationship, Nat. Methods, 2, 333, 10.1038/nmeth758

Riaz, 2002, The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitro, Brain. Res. Dev. Brain. Res., 136, 27, 10.1016/S0165-3806(02)00310-3

Roelofs, 2005, Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton, Glia, 52, 289, 10.1002/glia.20243

Sah, 1997, Bipotent progenitor cell lines from the human CNS, Nat. Biotechnol., 15, 574, 10.1038/nbt0697-574

Santa-Olalla, 1999, Basic fibroblast growth factor promotes epidermal growth factor responsiveness and survival of mesencephalic neural precursor cells, J. Neurobiol., 40, 14, 10.1002/(SICI)1097-4695(199907)40:1<14::AID-NEU2>3.0.CO;2-U

Seaberg, 2002, Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors, J. Neurosci., 22, 1784, 10.1523/JNEUROSCI.22-05-01784.2002

Silva, 2006, Nanog promotes transfer of pluripotency after cell fusion, Nature, 441, 997, 10.1038/nature04914

Singec, 2006, Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology, Nat. Methods, 3, 801, 10.1038/nmeth926

Singh, 2004, Cancer stem cells in nervous system tumors, Oncogene, 23, 7267, 10.1038/sj.onc.1207946

Suslov, 2002, Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres, Proc. Natl. Acad. Sci. U. S. A., 99, 14506, 10.1073/pnas.212525299

Svendsen, 1998, A new method for the rapid and long term growth of human neural precursor cells, J. Neurosci. Methods, 85, 141, 10.1016/S0165-0270(98)00126-5

Villa, 2000, Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS, Exp. Neurol., 161, 67, 10.1006/exnr.1999.7237

Villa, 2004, Long-term molecular and cellular stability of human neural stem cell lines, Exp. Cell Res., 294, 559, 10.1016/j.yexcr.2003.11.025

Wright, 2003, Gene expression in human neural stem cells: effects of leukemia inhibitory factor, J. Neurochem., 86, 179, 10.1046/j.1471-4159.2003.01826.x

Yan, 2007, Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord, PLoS Med., 4, e39, 10.1371/journal.pmed.0040039

Yanada, 2006, Possibility of selection of chondrogenic progenitor cells by telomere length in FGF-2-expanded mesenchymal stromal cells, Cell Prolif., 39, 575, 10.1111/j.1365-2184.2006.00397.x

Ying, 2003, Defined conditions for neural commitment and differentiation, Methods Enzymol., 365, 327, 10.1016/S0076-6879(03)65023-8

Zhang, 2001, In vitro differentiation of transplantable neural precursors from human embryonic stem cells, Nat. Biotechnol., 19, 1129, 10.1038/nbt1201-1129