Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection

AIDS - Tập 24 Số 10 - Trang 1598-1601 - 2010
Laurent Hocqueloux1,2,3,4, Thiérry Prazuck1, Véronique Avettand-Fènoël5,6, Alain Lafeuillade7, Bernard Cardon8, Jean‐Paul Viard5,9, Christine Katlama5,6
1Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Régional, Orléans, France
2e-mail: [email protected]
3fax: +33 2385 14153
4to Dr Laurent Hocqueloux, Service de Maladies Infectieuses et Tropicales, CHR d'Orléans – La Source, BP 86709, 45067 Orléans Cedex 2, France. Tel: +33 2382 29588
5EA 3620, Université Paris Descartes, Paris, France
6Laboratoire de Virologie, APHP, Hôpital Necker-Enfants Malades, France
7Service de Maladies Infectieuses et Tropicales, Hôpital Font Pré, Toulon, France
8Service de Maladies Infectieuses et Tropicales, Hôpital Tenon, France
9Service de maladies infectieuses et tropicales, Hôpital Necker-Enfants Malades, Paris, France

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Tài liệu tham khảo

Hicks, 2007, Acute HIV infection: the impact of antiretroviral treatment on cellular immune responses, Clin Exp Immunol, 149, 211, 10.1111/j.1365-2249.2007.03437.x

Cellerai, 2008, Treatment of acute HIV infection: are we getting there?, Curr Opin HIV AIDS, 3, 67, 10.1097/COH.0b013e3282f31d4b

Rowland-Jones, 2008, Resisting immune exhaustion in HIV-1 infection, PLoS Med, 5, e103, 10.1371/journal.pmed.0050103

Avettand-Fènoël, 2009, French Pediatric Cohort Study ANRS-CO 01 Group. LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01), J Med Virol, 81, 217, 10.1002/jmv.21390

Lambotte, 2005, SEROCO-HEMOCO Study Group. HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication, Clin Infect Dis, 41, 1053, 10.1086/433188

Goujard, 2009, Agence Nationale de Recherche sur le Sida PRIMO Study Group. Spontaneous control of viral replication during primary HIV infection: when is ‘HIV controller’ status established?, Clin Infect Dis, 49, 982, 10.1086/605504

Sáez-Cirión, 2007, HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype, Proc Natl Acad Sci U S A, 104, 6776, 10.1073/pnas.0611244104

Yerly, 2004, Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions, AIDS, 18, 1951, 10.1097/00002030-200409240-00011

Rouzioux, 2005, Early levels of HIV-1 DNA in peripheral blood mononuclear cells as a predictor of disease progression independently of HIV-1 RNA levels and CD4+ T cell counts, J Infect Dis, 192, 46, 10.1086/430610

Avettand-Fenoel, 2008, HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term nonprogressors, AIDS, 22, 1880, 10.1097/QAD.0b013e32830fbdbc

Viard, 2004, Impact of 5 years of maximally successful HAART on CD4 cell count and HIV-1 DNA level, AIDS, 18, 45, 10.1097/00002030-200401020-00005

Martinez, 2005, Asymptomatiques à Long Terme Study Group. Combination of HIV-1-specific CD4 Th1 cell responses and IgG2 antibodies is the best predictor for persistence of long-term nonprogression, J Infect Dis, 191, 2053, 10.1086/430320

McMichael, 2010, The immune response during acute HIV-1 infection: clues for vaccine development, Nat Rev Immunol, 10, 11, 10.1038/nri2674