Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?

Morgan, 1976, Selective in vitro growth of T-lymphocytes from normal human bone marrows, Science, 193, 1007, 10.1126/science.181845 Walford, 1981, Evidence for in vitro senescence of T-lymphocytes cultured from normal human peripheral blood, Age, 4, 67, 10.1007/BF02431987 Effros, 1984, T cell cultures and the Hayflick limit, Human Immunology, 9, 49, 10.1016/0198-8859(84)90006-5 Ho, 1993, A Phase-1 Study of Adoptive Transfer of Autologous CD8+ T-Lymphocytes in Patients with Acquired Immunodeficiency Syndrome (AIDS)-Related Complex or AIDS, Blood, 81, 2093, 10.1182/blood.V81.8.2093.2093 Kawakami, 1994, Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection, 91, 6458 Johnson, 1982, Karyotype evolution of cytolytic T cell lines, 183 Grubeck-Loebenstein, 1994, Long-term in vitro growth of human T cell clones: Can postmitotic ‘senescent’ cell populations be defined?, Int. Arch. Allergy. Immunol., 104, 232, 10.1159/000236671 McCarron, 1987, Effect of age on lymphocyte proliferation, Mech. Ageing. Dev., 41, 211, 10.1016/0047-6374(87)90041-8 Perillo, 1993, The In vitro Senescence of Human T-Lymphocytes — Failure to Divide Is Not Associated with a Loss of Cytolytic Activity or Memory T-Cell Phenotype, Mech. Ageing Dev., 67, 173, 10.1016/0047-6374(93)90121-7 Testi, 1989, Functional expression of CD28 on T cell antigen receptor gamma/δ-bearing T lymphocytes, Eur. J. Immunol., 19, 185, 10.1002/eji.1830190129 Effros, 1994, Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence, Exp. Gerontol., 29, 601, 10.1016/0531-5565(94)90073-6 Guinan, 1994, Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity, Blood, 84, 3261, 10.1182/blood.V84.10.3261.3261 Perillo, 1993, In vitro Cellular Aging in T-Lymphocyte Cultures — Analysis of DNA Content and Cell Size, Exp. Cell. Res., 207, 131, 10.1006/excr.1993.1171 Pawelec, 1993, Cloning and propagation of human T lymphocytes, 131 Pohla, 1993, Evolution of a CD3 + CD4 + alpha/beta T-cell receptor-positive mature T cell clone from CD3− CD7+ sorted human bone marrow cells, Dev. Immunol., 3, 197, 10.1155/1993/59852 Adibzadeh, 1994, Extrathymic Development and Function of Human T-Lymphocytes from Bone Marrow Cells in Vitro, Cell. Immunol., 154, 25, 10.1006/cimm.1994.1054 Pawelec, 1995, Analysis of MHC class II-specific T cell clones Obata, 1993, Human T-Cell Receptor TCRAV, TCRBV, and TCRAJ Sequences Newly Found in T-Cell Clones Reactive with Allogeneic HLA Class-II Antigens, Immunogenetics, 38, 67, 10.1007/BF00216395 Schaudt, 1991, Computerised transfer and processing of data from experiments measuring cellular proliferation by incorporation of tritiated thymidine, J. Immunol. Methods., 138, 155, 10.1016/0022-1759(91)90163-A Franceschi, 1995, The immunology of exceptional individuals: the lesson of centenarians, Immunol. Today., 16, 12, 10.1016/0167-5699(95)80064-6 Murasko, 1988, Association of lack of mitogen induced lymphocyte proliferation with increased mortality in the elderly, Ageing: Immunology and Infectious Disease, 1, 1 Pawelec, 1983, Human T-cell clones with multiple and changing functions: indications of unexpected flexibility in immune response networks, Immunology Today, 4, 275, 10.1016/0167-5699(83)90134-2 Lake, 1993, CD28 Messenger RNA Rapidly Decays When Activated T-Cells Are Functionally Anergized with Specific Peptide, Int. Immunol., 5, 461, 10.1093/intimm/5.5.461 Suzuki, 1995, Impaired CD28-mediated co-stimulation in anergic T cells, Int. Immunol., 7, 37, 10.1093/intimm/7.1.37 Pawelec, 1986, Acquisition of suppressive activity and natural killer-like cytotoxicity by human alloproliferative ‘helper’ T cell clones, J. Immunol., 136, 402, 10.4049/jimmunol.136.2.402 Qin, 1993, Infectious Transplantation Tolerance, Science, 259, 974, 10.1126/science.8094901 Lombardi, 1994, Anergic T cells as suppressor cells in vitro, Science, 264, 1587, 10.1126/science.8202711 Gimmi, 1993, Human T-Cell Clonal Anergy Is Induced by Antigen Presentation in the Absence of B7 Costimulation, 90, 6586 Linsley, 1991, Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation, J. Exp. Med., 173, 721, 10.1084/jem.173.3.721 Linsley, 1991, CTLA-4 Is a Second Receptor for the B-Cell Activation Antigen-B7, J. Exp. Med., 174, 561, 10.1084/jem.174.3.561 Walunas, 1994, CTLA-4 can function as a negative regulator of T cell activation, Immunity, 1, 405, 10.1016/1074-7613(94)90071-X Sethna, 1994, A negative regulatory function of B7 revealed in B7-1 transgenic mice, Immunity, 1, 415, 10.1016/1074-7613(94)90072-8