Long-term air pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan

Occupational and Environmental Medicine - Tập 68 Số 1 - Trang 64-68 - 2011
Kai-Jen Chuang1,2, Yuan‐Horng Yan3,2, Shu-Yi Chiu2, Tsun‐Jen Cheng4
1Department of Cosmetic Application and Management, St. Mary's Medicine Nursing and Management College, Sanxing Township, Yilan County, Taiwan
2Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei City, Taiwan
3Department of Medical Research, Chia-Yi Christian Hospital, Chiayi City, Taiwan
4National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, No. 17 Xu-Zhou Road, Zhongzheng District, Taipei 10055, Taiwan

Tóm tắt

ObjectivesTo investigate changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation associated with changes in long-term exposure to ambient air pollutants.MethodsWe conducted secondary analyses of data on blood pressure and blood biochemistry markers from the Social Environment and Biomarkers of Aging Study in Taiwan and air pollution data from the Taiwan Environmental Protection Administration in 2000. Associations of 1-year averaged criteria air pollutants (particulate matter with aerodynamic diameters <10 μm (PM10) and <2.5 μm (PM2.5), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide and carbon monoxide) with systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting glucose, haemoglobin A1c (HbA1c), interleukin 6 (IL-6) and neutrophils were explored by applying generalised additive models.ResultsAfter controlling for potential confounders, we observed that increased 1-year averaged particulate air pollutants (PM10and PM2.5) and NO2were associated with elevated blood pressure, total cholesterol, fasting glucose, HbA1c, IL-6 and neutrophils. Associations of increased 1-year averaged O3with elevated blood pressure, total cholesterol, fasting glucose, HbA1c and neutrophils were also observed. In particular, our two-pollutant models showed that PM2.5was more significantly associated with end-point variables than two gaseous pollutants, O3and NO2.ConclusionsChanges in blood pressure, blood lipids, blood sugar and haematological markers of inflammation are associated with long-term exposure to ambient air pollutants. This might provide a link between air pollution and atherosclerotic cardiovascular diseases.

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Thông tin xuất bản

Occupational and Environmental Medicine

Tập 68 Số 1

64-68

Thông tin tác giả