Long-term Testis Cancer Survivors in Canada—Mortality Risks in a Large Population-based Cohort

Canadian Cancer Society, 2019 Hanna, 2014, Testicular cancer: a reflection on 50 years of discovery, J Clin Oncol, 32, 3085, 10.1200/JCO.2014.56.0896 Verdecchia, 2007, Recent cancer survival in Europe: a 2000–02 period analysis of EUROCARE-4 data, Lancet Oncol, 8, 784, 10.1016/S1470-2045(07)70246-2 International Germ Cell Cancer Collaborative Group, 1997, International Germ Cell Consensus classification: a prognostic factor-based staging system for metastatic germ cell cancers, J Clin Oncol, 15, 594, 10.1200/JCO.1997.15.2.594 Subramanian, 2010, Complications of open primary and post-chemotherapy retroperitoneal lymph node dissection for testicular cancer, Urol Oncol Semin Orig Investig, 28, 504 Hanna N., Timmerman R., Foster R.S., Roth B.J., Einhorn L.H., Nichols C.R. Long-term toxicity of radiation therapy. (Eds) Kufe DW, Pollock RE, Weichselbaum RR, et al. Holland-Frei cancer medicine. NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK13384/. Fosså, 2009, Short- and long-term morbidity after treatment for testicular cancer, BJU Int, 104, 1418, 10.1111/j.1464-410X.2009.08869.x Gilligan, 2011, Testicular cancer survivorship, Hematol Oncol Clin North Am, 25, 627, 10.1016/j.hoc.2011.03.010 Tarin, 2009, Estimating the risk of cancer associated with imaging related radiation during surveillance for stage I testicular cancer using computerized tomography, J Urol, 181, 627, 10.1016/j.juro.2008.10.005 Salminen, 2017, Cancer death risk related to radiation exposure from computed tomography scanning among testicular cancer patients, Anticancer Res, 37, 831, 10.21873/anticanres.11385 Haugnes, 2010, Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study, J Clin Oncol, 28, 4649, 10.1200/JCO.2010.29.9362 van Den Belt-Dusebout, 2006, Long-term risk of cardiovascular disease in 5-year survivors of testicular cancer, J Clin Oncol, 24, 467, 10.1200/JCO.2005.02.7193 Travis, 2005, Second cancers among 40 576 testicular cancer patients: focus on long-term survivors, JNCI J Natl Cancer Inst, 97, 1354, 10.1093/jnci/dji278 Travis, 1997, Risk of second malignant neoplasms among long-term survivors of testicular cancer, J Natl Cancer Inst, 89, 1429, 10.1093/jnci/89.19.1429 van den Belt-Dusebout, 2007, Treatment-specific risks of second malignancies and cardiovascular disease in 5-year survivors of testicular cancer, J Clin Oncol, 25, 4370, 10.1200/JCO.2006.10.5296 Einhorn, 1981, Testicular cancer as a model for a curable neoplasm: the Richard and Hinda Rosenthal Foundation award lecture, Cancer Res, 41, 3275 Fung, 2015, Long-term morbidity of testicular cancer treatment, Urol Clin North Am, 42, 393, 10.1016/j.ucl.2015.05.002 Kourie, 2017, Physical long-term side-effects in young adult cancer survivors: germ cell tumors model, Curr Opin Oncol, 29, 229, 10.1097/CCO.0000000000000375 Kamran, 2018, Contemporary treatment patterns and outcomes for clinical stage IS testicular cancer, Eur Urol, 73, 262, 10.1016/j.eururo.2017.06.013 Willemse, 2013, Prevalence of the metabolic syndrome and cardiovascular disease risk in chemotherapy-treated testicular germ cell tumour survivors, Br J Cancer, 109, 60, 10.1038/bjc.2013.226 Fung, 2015, Cardiovascular disease mortality after chemotherapy or surgery for testicular nonseminoma: a population-based study, J Clin Oncol, 33, 3106, 10.1200/JCO.2014.60.3654 Adams, 2017, Effects of high-intensity aerobic interval training on cardiovascular disease risk in testicular cancer survivors: A phase 2 randomized controlled trial, Cancer, 123, 4057, 10.1002/cncr.30859 Feldman, 2018, Predicting cardiovascular disease among testicular cancer survivors after modern cisplatin-based chemotherapy: application of the Framingham risk score, Clin Genitourin Cancer, 16, e761, 10.1016/j.clgc.2018.01.011 Fosså, 2004, Increased mortality rates in young and middle-aged patients with malignant germ cell tumours, Br J Cancer, 90, 607, 10.1038/sj.bjc.6601558 Dores, 2002, Second malignant neoplasms among long-term survivors of Hodgkin’s disease: a population-based evaluation over 25 years, J Clin Oncol, 20, 3484, 10.1200/JCO.2002.09.038 Van Leeuwen, 1995, Roles of radiotherapy and smoking in lung cancer following Hodgkin’s disease, J Natl Cancer Inst, 87, 1530, 10.1093/jnci/87.20.1530 Travis, 2002, Lung cancer following chemotherapy and radiotherapy for Hodgkin’s disease, Cancer Spectrum Knowl Environ, 94, 182 Inskip, 1994, Lung cancer risk and radiation dose among women treated for breast cancer, J Natl Cancer Inst, 86, 983, 10.1093/jnci/86.13.983 Alanee, 2014, Long-term mortality in patients with germ cell tumors: effect of primary cancer site on cause of death, Urol Oncol Semin Orig Investig, 32, 9 Zagars, 2004, Mortality after cure of testicular seminoma, J Clin Oncol, 22, 640, 10.1200/JCO.2004.05.205 Fosså, 2007, Noncancer causes of death in survivors of testicular cancer, JNCI J Natl Cancer Inst, 99, 533, 10.1093/jnci/djk111 Peters, 2013, Data resource profile: 1991 Canadian Census Cohort, Int J Epidemiol, 42, 1319, 10.1093/ije/dyt147