Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses

OncoImmunology - Tập 7 Số 12 - Trang e1500671 - 2018
Jasmin Quandt1,2, Christoph Schlude1, Michael Bartoschek1,3, Rainer Will4, Angel Cid‐Arregui1,5, Sebastian Schölch6,7, Christoph‐Thomas Germer6,7, Jürgen Weitz8, Martin Schneider7, Stefan Wiemann9,4, Frank Momburg10,1, Philipp Beckhove1,11
1Department of Translational Immunology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany
2Knapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA
3Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden
4Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany
5Targeted Tumor Vaccines Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany
6Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
7Department of Visceral Surgery, University Hospital Heidelberg, Heidelberg, Germany
8Department of Visceral, Thoracic, and Vascular Surgery, Medizinische Fakultaet an der TU-Dresden, Dresden, Germany
9Division Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
10Antigen Presentation and T/NK Cell Activation Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany
11Regensburg Center for Interventional Immunology (RCI), University Regensburg and Department of Hematology-Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1038/nrc3670

10.1172/JCI74894

10.1084/jem.181.6.2109

10.1016/S0065-2776(04)82006-6

10.1016/S0065-230X(06)95001-5

10.1126/science.1840703

Ressing ME, 1995, J Immunol, 154, 5934, 10.4049/jimmunol.154.11.5934

10.1038/25292

10.1126/science.1235122

10.1056/NEJMoa1113205

10.1038/nature10755

10.1016/0092-8674(90)90186-I

10.1038/nrc949

10.1002/eji.1830231045

10.1007/s00109-002-0390-y

10.1002/eji.1830260225

10.1006/cimm.1997.1224

10.1097/00002371-199903000-00007

Ciernik IF, 1996, Clin Cancer Res, 2, 877

10.1084/jem.183.4.1357

10.1002/1097-0215(200102)9999:9999<::AID-IJC1152>3.0.CO;2-Q

10.1158/0008-5472.CAN-04-0484

Schmitz-Winnenthal FH, 2006, Int J Oncol, 28, 1419

10.1158/0008-5472.CAN-05-4201

10.1158/0008-5472.CAN-05-2363

10.1172/JCI20278

10.1038/86523

10.1158/0008-5472.CAN-05-1098

10.1172/JCI39608

10.4161/onci.24962

10.1007/s00262-017-1964-4

10.1038/nrc2373

10.4049/jimmunol.179.8.5033

10.1038/nri2780

10.1038/nature13387

10.4049/jimmunol.166.12.7144

10.1002/eji.200324427

10.1016/B978-0-12-396548-6.00003-2

10.1586/erv.12.39

10.1111/j.1423-0410.1998.tb05462.x

10.1186/1479-5876-12-55

10.1002/ijc.1205

10.1002/ijc.25449

10.1200/JCO.2005.03.158

10.1016/j.smim.2013.04.008

10.1038/nrclinonc.2014.111

10.1038/nm.2883

10.1016/S1470-2045(16)30408-9

10.1073/pnas.86.7.2403

10.1038/312071a0

10.1038/sj.bjc.6601894

10.1002/humu.20495

10.1038/nature00766

10.1016/j.jim.2006.07.015

10.1007/s00262-010-0875-4

10.1007/978-1-61779-325-7_15

10.1093/bioinformatics/btn128

Karosiene E, 2013, A Common Pan-Specific MHC Class II Prediction Method Including All Three Human MHC Class II Isotypes, HLA-DR, HLA-DP and HLA-DQ. Immunogenetics, 65, 711

10.1007/s002510050595

10.1002/cncr.24988

10.1158/0008-5472.CAN-13-0875

10.1038/nm.3105

10.4049/jimmunol.1402384

10.1158/0008-5472.CAN-07-3166

10.1158/1078-0432.CCR-08-2227

10.1056/NEJMoa0810097

10.1038/nature23003

10.1038/nature14426

10.1158/0008-5472.CAN-11-3722

10.1002/eji.200737995

10.1002/(SICI)1097-0215(19970904)72:5<784::AID-IJC14>3.0.CO;2-9

10.1007/s00262-006-0225-8

10.1038/nri1029

10.4161/onci.20298

10.1128/JVI.01830-06

10.1182/blood-2005-12-4818

10.1038/nm1592

10.1002/eji.200425463

Thông tin
Thông tin xuất bản

OncoImmunology

Tập 7 Số 12

e1500671

Thông tin tác giả