Long non‐coding RNAs as novel diagnostic and therapeutic targets in kidney disease

Chronic Diseases and Translational Medicine - Tập 5 - Trang 252-257 - 2019
Qin Zhou1,2,3, Wei Chen1,2,3, Xue-Qing Yu1,2,3,4
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
2National Health Commission Key Laboratory of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
3Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
4Guangdong General Hospital, Guangzhou, Guangdong 510080, China

Tóm tắt

AbstractLong non‐coding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury (AKI), chronic kidney disease (CKD), and renal cell carcinoma (RCC). Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment.

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Thông tin xuất bản

Chronic Diseases and Translational Medicine

Tập 5

252-257

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