Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides

Alexopoulou, 2001, Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3, Nature, 413, 732, 10.1038/35099560 Alonso, 1981, Radioautographic studies on the neurohypophysial projections of the supraoptic and paraventricular nuclei in the rat, Cell Tissue Res., 219, 525, 10.1007/BF00209991 Bhargava, 2002, Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1, Mol. Endocrinol., 16, 1629, 10.1210/me.16.7.1629 Bienemann, 2003, Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin, Molec. Ther., 7, 588, 10.1016/S1525-0016(03)00069-8 Billy, 2001, Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines, Proc. Natl. Acad. Sci. U. S. A., 98, 14428, 10.1073/pnas.261562698 Bittencourt, 1999, Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors, J. Comp. Neurol., 415, 285, 10.1002/(SICI)1096-9861(19991220)415:3<285::AID-CNE1>3.0.CO;2-0 Bridge, 2003, Induction of an interferon response by RNAi vectors in mammalian cells, Nat. Genet., 34, 263, 10.1038/ng1173 Chiasson, 1994, The application of antisense oligonucleotide technology to the brain: some pitfalls, Cell. Mol. Neurobiol., 14, 507, 10.1007/BF02088834 Clemens, 1997, The double-stranded RNA-dependent protein kinase PKR: structure and function, J. Interferon Cytokine Res., 17, 503, 10.1089/jir.1997.17.503 Fire, 1998, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature, 391, 806, 10.1038/35888 Gaillet, 1993, Effects of discrete lesions in the ventral noradrenergic ascending bundle on the corticotropic stress response depend on the site of the lesion and on the plasma levels of adrenal steroids, Neuroendocrinology, 58, 408, 10.1159/000126570 Gan, 2002, Specific interference with gene expression and gene function mediated by long dsRNA in neural cells, J. Neurosci. Methods, 121, 151, 10.1016/S0165-0270(02)00230-3 Gudima, 2001, Search for antisense copies of beta-globin mRNA in anemic mouse spleen, BMC Biochem., 2, 3, 10.1186/1471-2091-2-3 Gutman, 2003, The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress, J. Pharmacol. Exp. Ther., 304, 874, 10.1124/jpet.102.042788 Hammond, 2000, An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells, Nature, 404, 293, 10.1038/35005107 Holloway, 2002, Urocortin: a mechanism for the sustained activation of the HPA axis in the late-gestation ovine fetus?, Am. J. Physiol.: Endocrinol. Metab., 283, E165, 10.1152/ajpendo.00497.2001 Kalra, 2000, Effects of centrally administered antisense oligodeoxynucleotides on feeding behavior and hormone secretion, Methods Enzymol., 314, 184, 10.1016/S0076-6879(99)14103-X Kehoe, 2001, Double-stranded RNA regulates IL-4 expression, J. Immunol., 167, 2496, 10.4049/jimmunol.167.5.2496 Koegler-Muly, 1993, Potential corticotropin-releasing factor pathways in the rat brain as determined by bilateral electrolytic lesions of the central amygdaloid nucleus and the paraventricular nucleus of the hypothalamus, J. Neuroendocrinol., 5, 95, 10.1111/j.1365-2826.1993.tb00367.x Krichevsky, 2002, RNAi functions in cultured mammalian neurons, Proc. Natl. Acad. Sci. U. S. A., 99, 11926, 10.1073/pnas.182272699 Levin, 1988, Corticosterone acts on the brain to inhibit adrenalectomy-induced adrenocorticotropin secretion, Endocrinology, 122, 694, 10.1210/endo-122-2-694 Lewis, 2002, Efficient delivery of siRNA for inhibition of gene expression in postnatal mice, Nat. Genet., 32, 107, 10.1038/ng944 Loftus, 2000, Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival, Gut, 46, 336, 10.1136/gut.46.3.336 Lovejoy, 1998, Ectopic expression of the CRF-binding protein: minor impact on HPA axis regulation but induction of sexually dimorphic weight gain, J. Neuroendocrinol., 10, 483, 10.1046/j.1365-2826.1998.00206.x Makimura, 2002, Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake, BMC Neurosci., 3, 18, 10.1186/1471-2202-3-18 McCaffrey, 2002, RNA interference in adult mice, Nature, 418, 38, 10.1038/418038a Muglia, 1995, Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need, Nature, 373, 427, 10.1038/373427a0 Napoli, 1990, Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans, Plant Cell, 2, 279, 10.1105/tpc.2.4.279 Parrish, 2000, Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference, Mol. Cell, 6, 1077, 10.1016/S1097-2765(00)00106-4 Paxinos, 1998 Perez, 1994, Sequence-independent induction of Sp1 transcription factor activity by phosphorothioate oligodeoxynucleotides, Proc. Natl. Acad. Sci. U. S. A., 91, 5957, 10.1073/pnas.91.13.5957 Rivest, 1991, Influence of the paraventricular nucleus of the hypothalamus in the alteration of neuroendocrine functions induced by intermittent footshock or interleukin, Endocrinology, 129, 2049, 10.1210/endo-129-4-2049 Robinson, 1985, Disorders of antiduretic hormone secretion, Clin. Endocrinol. Metab., 14, 55, 10.1016/S0300-595X(85)80065-7 Schmale, 1993, Structure and expression of the vasopressin precursor gene in central diabetes insipidus, Ann. N.Y. Acad. Sci., 689, 74, 10.1111/j.1749-6632.1993.tb55538.x Sledz, 2003, Activation of the interferon system by short-interfering RNAs, Nat. Cell Biol., 5, 834, 10.1038/ncb1038 Smagin, 1998, The role of CRF2 receptors in corticotropin-releasing factor- and urocortin-induced anorexia, NeuroReport, 9, 1601, 10.1097/00001756-199805110-00063 Stricker, 1990, Sodium appetite, vol. 10, 387 Svoboda, 2000, Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference, Development, 127, 4147, 10.1242/dev.127.19.4147 Swanson, 1983, Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study, Neuroendocrinology, 36, 165, 10.1159/000123454 Szweykowska-Kulinska, 2003, RNA interference and its role in the regulation of eucaryotic gene expression, Acta Biochim. Pol., 50, 217, 10.18388/abp.2003_3730 Whitnall, 1993, Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system, Prog. Neurobiol., 40, 573, 10.1016/0301-0082(93)90035-Q Wianny, 2000, Specific interference with gene function by double-stranded RNA in early mouse development, Nat. Cell Biol., 2, 70, 10.1038/35000016