Long Non-coding RNAs: At the Heart of Cardiac Dysfunction?

Lisa Hobuß1, Christian Bär1, Thomas Thum1,2
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hanover, Germany
2National Heart and Lung Institute, Imperial College London, London, United Kingdom

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Bennett, 2017, Pharmacology of Antisense drugs., Annu. Rev. Pharmacol. Toxicol., 57, 81, 10.1146/annurev-pharmtox-010716-104846

Burdick, 2014, Sequence motifs associated with hepatotoxicity of locked nucleic acid-modified antisense oligonucleotides., Nucleic Acids Res., 42, 4882, 10.1093/nar/gku142

Chen, 2018, Valsartan regulates TGF-β/Smads and TGF-β/p38 pathways through lncRNA CHRF to improve doxorubicin-induced heart failure., Arch. Pharm. Res., 41, 101, 10.1007/s12272-017-0980-4

De Gonzalo-Calvo, 2016, Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes., Sci. Rep., 6, 1, 10.1038/srep37354

Devaux, 2015, Long noncoding RNAs in cardiac development and ageing., Nat. Rev. Cardiol., 12, 415, 10.1038/nrcardio.2015.55

Gast, 2018, Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-/-mice., Cardiovasc. Res., 10.1093/cvr/cvy202

Geary, 2015, Clinical and Preclinical pharmacokinetics and pharmacodynamics of mipomersen (Kynamro®): a Second-generation antisense oligonucleotide inhibitor of apolipoprotein B., Clin. Pharmacokinet., 54, 133, 10.1007/s40262-014-0224-4

Grote, 2015, Long noncoding RNAs in organogenesis: making the difference., Trends Genet., 31, 329, 10.1016/j.tig.2015.02.002

Grote, 2013, The tissue-specific lncrna fendrr is an essential regulator of heart and body wall development in the mouse., Dev. Cell, 24, 206, 10.1016/j.devcel.2012.12.012

Gutschner, 2017, From biomarkers to therapeutic targets – The promises and perils of long non-coding RNAs in cancer., Cancer Metastasis Rev., 37, 83, 10.1007/s10555-017-9718-5

Han, 2014, A long noncoding RNA protects the heart from pathological hypertrophy., Nature, 514, 102, 10.1038/nature13596

Huang, 2018, Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model., J. Cell. Physiol., 1, 1, 10.1002/jcp.27117

Ishii, 2006, Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction., J. Hum. Genet., 51, 1087, 10.1007/s10038-006-0070-9

Klattenhoff, 2013, Braveheart, a long noncoding RNA required for cardiovascular lineage commitment., Cell, 152, 570, 10.1016/j.cell.2013.01.003

Krenz, 2004, Impact of beta-myosin heavy chain expression on cardiac function during stress., J. Am. Coll. Cardiol., 44, 2390, 10.1016/j.jacc.2004.09.044

Kumarswamy, 2014, Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure., Circ. Res., 114, 1569, 10.1161/CIRCRESAHA.114.303915

Lai, 2017, HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy., Mol. Cell. Biochem., 432, 179, 10.1007/s11010-017-3008-y

Lennox, 2016, Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides., Nucleic Acids Res., 44, 863, 10.1093/nar/gkv1206

Li, , Obestatin attenuated doxorubicin-induced cardiomyopathy via enhancing long noncoding Mhrt RNA expression., Biomed. Pharmacother., 81, 474, 10.1016/j.biopha.2016.04.017

Li, 2015, Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer., Tumor Biol., 36, 2007, 10.1007/s13277-014-2807-y

Li, , LncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy., Sci. Rep., 6, 1, 10.1038/srep36340

Li, 2017, Inhibition of the lncRNA Mirt1 attenuates acute myocardial infarction by suppressing NF-κB activation., Cell. Physiol. Biochem., 42, 1153, 10.1159/000478870

Li, 2018, LncRNA myocardial infarction-associated transcript (MIAT) contributed to cardiac hypertrophy by regulating TLR4 via miR-93., Eur. J. Pharmacol., 818, 508, 10.1016/j.ejphar.2017.11.031

Liu, 2016, The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy., Cardiovasc. Res., 111, 56, 10.1093/cvr/cvw078

Long, 2018, Long noncoding RNA FTX regulates cardiomyocyte apoptosis by targeting miR-29b-1-5p and Bcl2l2., Biochem. Biophys. Res. Commun., 495, 312, 10.1016/j.bbrc.2017.11.030

Lucas, 2018, RNA therapeutics in cardiovascular disease., Circ. Res., 123, 205, 10.1161/CIRCRESAHA.117.311311

Martignano, 2017, Urinary RNA-based biomarkers for prostate cancer detection., Clin. Chim. Acta, 473, 96, 10.1016/j.cca.2017.08.009

Mendell, 2016, Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy., Ann. Neurol., 79, 257, 10.1002/ana.24555

Mendell, 2013, Eteplirsen for the treatment of Duchenne muscular dystrophy., Ann. Neurol., 37, e109, 10.1002/ana.23982

Micheletti, 2017, The long noncoding RNA Wisper controls cardiac fibrosis and remodeling., Sci. Transl. Med., 9, 10.1126/scitranslmed.aai9118

Miyata, 2000, 86, 386, 10.1161/01.RES.86.4.386

Noh, 2018, Cytoplasmic functions of long noncoding RNAs., Wiley Interdiscip. Rev. RNA, 9, 10.1002/wrna.1471

Pan, 2017, Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression., J. Cancer Res. Clin. Oncol., 143, 991, 10.1007/s00432-017-2361-2

Piccoli, 2017, Inhibition of the cardiac fibroblast-enriched lncRNA Meg3 prevents cardiac fibrosis and diastolic dysfunction., Circ. Res., 121, 575, 10.1161/CIRCRESAHA.117.310624

Qu, 2017, MIAT is a pro-fibrotic long non-coding RNA governing cardiac fibrosis in post-infarct myocardium., Sci. Rep., 7, 1, 10.1038/srep42657

Quiat, 2013, MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment., J. Clin. Invest., 123, 11, 10.1172/JCI62876.mature

Rader, 2014, Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia., Circulation, 129, 1022, 10.1161/CIRCULATIONAHA.113.001292

Rahimi, 2018, Association of ANRIL expression with coronary artery disease in type 2 diabetic patients., Cell J., 20, 41, 10.22074/cellj.2018.4821

Raveh, 2015, The H19 long non-coding RNA in cancer initiation, progression and metastasis – A proposed unifying theory., Mol. Cancer, 14, 1, 10.1186/s12943-015-0458-2

Santos, 2015, Mipomersen, an Antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in Various populations with hypercholesterolemia: results of 4 phase III trials., Arterioscler. Thromb. Vasc. Biol., 35, 689, 10.1161/ATVBAHA.114.304549

Smith, 2019, Therapeutic oligonucleotides: state of the art., Annu. Rev. Pharmacol. Toxicol., 59, 10.1146/annurev-pharmtox-010818-021050

Sun, 2017, Nuclear long noncoding RNAs: key regulators of gene expression., Trends Genet., 34, 142, 10.1016/j.tig.2017.11.005

Swayze, 2007, Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals., Nucleic Acids Res., 35, 687, 10.1093/nar/gkl1071

Terracciano, 2017, Urinary long noncoding RNAs in nonmuscle-invasive bladder cancer: new architects in cancer prognostic biomarkers., Transl. Res., 184, 108, 10.1016/j.trsl.2017.03.005

Thum, 2014, Noncoding RNAs and myocardial fibrosis., Nat. Rev. Cardiol., 11, 655, 10.1038/nrcardio.2014.125

Van Den Borne, 2010, Myocardial remodeling after infarction: the role of myofibroblasts., Nat. Rev. Cardiol., 7, 30, 10.1038/nrcardio.2009.199

Vausort, 2014, Long noncoding RNAs in patients with acute myocardial infarction., Circ. Res., 115, 668, 10.1161/CIRCRESAHA.115.303836

Viereck, 2016, Long noncoding RNA Chast promotes cardiac remodeling., Sci. Transl. Med., 8, a22, 10.1126/scitranslmed.aaf1475

Viereck, 2017, Circulating noncoding RNAs as biomarkers of cardiovascular disease and injury., Circ. Res., 120, 381, 10.1161/CIRCRESAHA.116.308434

Wang, 2017, Prognostic Value of plasma long noncoding RNA ANRIL for in-stent restenosis., Med. Sci. Monit., 23, 4733, 10.12659/MSM.904352

Wang, 2015, MicroRNA-103/107 regulate programmed necrosis and myocardial ischemia/reperfusion injury through targeting FADD., Circ. Res., 117, 352, 10.1161/CIRCRESAHA.117.305781

Wang, , The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489., Circ. Res., 114, 1377, 10.1161/CIRCRESAHA.114.302476

Wang, , CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation., Nat. Commun., 5, 10.1038/ncomms4596

Wang, , MDRL lncRNA Regulates the processing of miR-484 primary transcript by targeting miR-361., PLoS Genet., 10, 10.1371/journal.pgen.1004467

Wang, 2016, The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy., Nat. Med., 22, 1131, 10.1038/nm.4179

2017, Fact Sheet Cardiovascular diseases (CVDs)

Wu, 2018, Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction., Gene Ther., 25, 511, 10.1038/s41434-018-0045-4

Xuan, 2017, Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure., J. Cell. Mol. Med., 21, 1803, 10.1111/jcmm.13101

Yeowell, 2009, TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2., J. Invest. Dermatol., 129, 1402, 10.1038/jid.2008.386

Zhang, 2018, Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer., Onco. Targets. Ther., 11, 291, 10.2147/OTT.S155134

Zhang, 2017, Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population., Sci. Rep., 7, 10.1038/s41598-017-07611-z

Zhou, 2018, Long non-coding RNA H19 protects acute myocardial infarction through activating autophagy in mice., Eur. Rev. Med. Pharmacol. Sci., 22, 5647

Zhou, 2015, Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer., Sci. Rep., 5, 1, 10.1038/srep11516

Zhou, 2017, lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy., Cell Death Dis., 8, 10.1038/cddis.2017.321

Zhu, 2016, LncRNA MIAT enhances cardiac hypertrophy partly through sponging miR-150., Eur. Rev. Med. Pharmacol. Sci., 20, 3653