Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

Cancer Cell - Tập 35 Số 3 - Trang 489-503.e8 - 2019
Shivani Srivastava1, Alexander I. Salter1, Denny Liggitt2, Sushma Yechan-Gunja1, Megha Sarvothama1, Kirsten Cooper1, Kimberly S. Smythe1, Jarrod A. Dudakov3,1, Robert H. Pierce1, Christoph Rader4, Stanley R. Riddell3,5,1
1Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D3-100, Seattle, WA 98109-1024, USA
2Department of Comparative Medicine, University of Washington, Seattle, WA 98109, USA
3Department of Immunology, University of Washington, Seattle, WA 98109, USA
4Department of Immunology and Microbiology, Scripps Research Institute, Jupiter, FL 33458, USA
5Department of Medicine, University of Washington, Seattle, WA 98109, USA

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