Locomotor activity and the expression of orexin A and orexin B in aged female rhesus macaques

Bourgin, 2000, Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons, J. Neurosci., 20, 7760, 10.1523/JNEUROSCI.20-20-07760.2000 Chemelli, 1999, Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation, Cell, 98, 437, 10.1016/S0092-8674(00)81973-X Downs, 2007, Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque, Neurobiol. Aging, 28, 1286, 10.1016/j.neurobiolaging.2006.05.025 Fronczek, 2005, The number of hypothalamic hypocretin (orexin) neurons is not affected in Prader-Willi syndrome, J. Clin. Endocrinol. Metab., 90, 5466, 10.1210/jc.2005-0296 Fronczek, 2007, Hypocretin (orexin) loss in Parkinson's disease, Brain, 130, 1577, 10.1093/brain/awm090 Fronczek, 2012, Hypocretin (orexin) loss in Alzheimer's disease, Neurobiol. Aging, 33, 1642, 10.1016/j.neurobiolaging.2011.03.014 Horvath, 1999, Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system, J. Comp. Neurol., 415, 145, 10.1002/(SICI)1096-9861(19991213)415:2<145::AID-CNE1>3.0.CO;2-2 Hunt, 2015, Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus, Neurobiol. Aging, 36, 292, 10.1016/j.neurobiolaging.2014.08.010 Nishino, 2000, Hypocretin (orexin) deficiency in human narcolepsy, Lancet, 355, 39, 10.1016/S0140-6736(99)05582-8 Peyron, 2000, A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains, Nat. Med., 6, 991, 10.1038/79690 Peyron, 1998, Neurons containing hypocretin (orexin) project to multiple neuronal systems, J. Neurosci., 18, 9996, 10.1523/JNEUROSCI.18-23-09996.1998 Sutcliffe, 2000, The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding, J. Neurosci. Res., 62, 161, 10.1002/1097-4547(20001015)62:2<161::AID-JNR1>3.0.CO;2-1 Thannickal, 2000, Reduced number of hypocretin neurons in human narcolepsy, Neuron, 27, 469, 10.1016/S0896-6273(00)00058-1 Urbanski, 2011, Circadian variation in the physiology and behavior of humans and nonhuman primates, 217 Urbanski, 2012, Changes in spontaneous activity assessed by accelerometry correlate with extent of cerebral ischemia-reperfusion injury in the nonhuman primate, Transl. Stroke Res., 3, 442, 10.1007/s12975-012-0191-8 Van Den Pol, 1999, Hypothalamic hypocretin (orexin): robust innervation of the spinal cord, J. Neurosci., 19, 3171, 10.1523/JNEUROSCI.19-08-03171.1999