Location-specific characteristics of perivascular spaces as the brain’s interstitial fluid drainage system

Iliff, 2012, A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta, Sci. Transl. Med., 4, 147ra11, 10.1126/scitranslmed.3003748 Nedergaard, 2013, Neuroscience. Garbage truck of the brain, Science, 340, 1529, 10.1126/science.1240514 Rasmussen, 2018, The glymphatic pathway in neurological disorders, The Lancet Neurology., 17, 1016, 10.1016/S1474-4422(18)30318-1 Iliff, 2017, 17 Zeppenfeld, 2017, Association of perivascular localization of aquaporin-4 with cognition and alzheimer disease in aging brains, JAMA neurology., 74, 91, 10.1001/jamaneurol.2016.4370 Charidimou, 2013, Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study, J. Neurol. Neurosurg. Psychiatry, 84, 624, 10.1136/jnnp-2012-304434 Charidimou, 2014, White matter perivascular spaces are related to cortical superficial siderosis in cerebral amyloid angiopathy, Stroke, 45, 2930, 10.1161/STROKEAHA.114.005568 Charidimou, 2017, MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy, Neurology, 21, 1157, 10.1212/WNL.0000000000003746 Charidimou, 2017, Emerging concepts in sporadic cerebral amyloid angiopathy, Brain J. Neurol., 140, 1829, 10.1093/brain/awx047 Heier, 1989, Large Virchow-Robin spaces: MR-clinical correlation, AJNR Am. J. Neuroradiol., 10, 929 Loos, 2015, Association between perivascular spaces and progression of white matter hyperintensities in lacunar stroke patients, PLoS One, 10, 10.1371/journal.pone.0137323 Wardlaw, 2013, Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration, The Lancet Neurology., 12, 822, 10.1016/S1474-4422(13)70124-8 Yakushiji, 2014, Topography and associations of perivascular spaces in healthy adults: the Kashima scan study, Neurology, 83, 2116, 10.1212/WNL.0000000000001054 Yang, 2017, The relationship between ambulatory blood pressure variability and enlarged perivascular spaces: a cross-sectional study, BMJ Open, 7, 10.1136/bmjopen-2016-015719 Ding, 2017, Large perivascular spaces visible on magnetic resonance imaging, cerebral small vessel disease progression, and risk of dementia: the age, gene/environment susceptibility-reykjavik study, JAMA Neurol., 74, 1105, 10.1001/jamaneurol.2017.1397 Nagelhus, 2013, Physiological roles of aquaporin-4 in brain, Physiol. Rev., 93, 1543, 10.1152/physrev.00011.2013 Hurford, 2014, MRI-visible perivascular spaces: relationship to cognition and small vessel disease MRI markers in ischaemic stroke and TIA, J. Neurol. Neurosurg. Psychiatry, 85, 522, 10.1136/jnnp-2013-305815 Riba-Llena, 2018, Arterial stiffness is associated with basal ganglia enlarged perivascular spaces and cerebral small vessel disease load, Stroke, 49, 1279, 10.1161/STROKEAHA.118.020163 Zhu, 2010, Severity of dilated Virchow-Robin spaces is associated with age, blood pressure, and MRI markers of small vessel disease: a population-based study, Stroke, 41, 2483, 10.1161/STROKEAHA.110.591586 Ishikawa, 2018, Dilated perivascular spaces in the centrum semiovale begin to develop in middle age, J. Alzheimers Dis.: JAD., 61, 1619, 10.3233/JAD-170755 Fazekas, 1987, MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging, AJR Am. J. Roentgenol., 149, 351, 10.2214/ajr.149.2.351 Zhang, 1990, Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum, J. Anat., 170, 111 Ishikawa, 2015, Three-dimensional observation of Virchow-Robin spaces in the basal ganglia and white matter and their relevance to idiopathic normal pressure hydrocephalus, Fluids and barriers of the CNS., 12, 15, 10.1186/s12987-015-0010-1 Saji, 2016, Cerebral small vessel disease and arterial stiffness: tsunami effect in the brain?, Pulse (Basel)., 3, 182, 10.1159/000443614 Iliff, 2013, Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain, J. Neurosci., 33, 18190, 10.1523/JNEUROSCI.1592-13.2013 Stoodley, 1997, Arterial pulsation-dependent perivascular cerebrospinal fluid flow into the central canal in the sheep spinal cord, J. Neurosurg., 86, 686, 10.3171/jns.1997.86.4.0686 Cserr, 1974, Relationship between cerebrospinal fluid and interstitial fluid of brain, Fed. Proc., 33, 2075 Cushing, 1914, Studies on the cerebro-spinal fluid: I. Introduction, J. Med. Res., 31, 1 Sofroniew, 2015, Astrocyte barriers to neurotoxic inflammation, Nat. Rev. Neurosci., 16, 249, 10.1038/nrn3898 Koennecke, 2006, Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications, Neurology, 66, 165, 10.1212/01.wnl.0000194266.55694.1e