Local inflammation and devascularization — in vivo mechanisms of the “bystander effect” in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma

Cancer Gene Therapy - Tập 8 Số 11 - Trang 843-851 - 2001
Frank Floeth1, N. Shand2, Hans Bojar3, Hans-Bernd Prisack3, Jörg Felsberg4, Eva Neuen-Jacob4, A. Aulich5, Klaus J. Burger6, W. J. Bock1, Friedrich Weber1
1Department of Neurosurgery, Heinrich Heine University, Düsseldorf, Germany
2Oncology Clinical Research, Novartis Pharma, Basel, Switzerland
3Department of Oncologic Chemistry, Heinrich-Heine-University, Düsseldorf, Germany
4Department of Neuropathology, Heinrich-Heine University, Düsseldorf, Germany.
5Department of Diagnostic Radiology, Heinrich Heine University, Düsseldorf, Germany
6Novartis Pharma AG, Nürnberg, Germany

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