Liver-targeting drugs and their effect on blood glucose and hepatic lipids

Springer Science and Business Media LLC - Tập 64 - Trang 1461-1479 - 2021
Amalia Gastaldelli1, Norbert Stefan2,3,4, Hans-Ulrich Häring2,3,4
1Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy
2Department of Internal Medicine IV, University of Tübingen, Tübingen, Germany
3Institute of Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich, Tübingen, Germany
4German Center for Diabetes Research, Neuherberg, Germany

Tóm tắt

The global epidemic of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) and the high prevalence among individuals with type 2 diabetes has attracted the attention of clinicians specialising in liver disorders. Many drugs are in the pipeline for the treatment of NAFLD/NASH, and several glucose-lowering drugs are now being tested specifically for the treatment of liver disease. Among these are nuclear hormone receptor agonists (e.g. peroxisome proliferator-activated receptor agonists, farnesoid X receptor agonists and liver X receptor agonists), fibroblast growth factor-19 and -21, single, dual or triple incretins, sodium–glucose cotransporter inhibitors, drugs that modulate lipid or other metabolic pathways (e.g. inhibitors of fatty acid synthase, diacylglycerol acyltransferase-1, acetyl-CoA carboxylase and 11β-hydroxysteroid dehydrogenase type-1) or drugs that target the mitochondrial pyruvate carrier. We have reviewed the metabolic effects of these drugs in relation to improvement of diabetic hyperglycaemia and fatty liver disease, as well as peripheral metabolism and insulin resistance.

Tài liệu tham khảo

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