Liver fibrogenic cells

Friedman, 2000, Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury, J Biol Chem, 275, 2247, 10.1074/jbc.275.4.2247

Parola, 2001, Oxidative stress – related molecules and liver fibrosis, J Hepatol, 35, 297, 10.1016/S0168-8278(01)00142-8

Friedman, 2003, Liver fibrosis: from bench to bedside, J Hepatol, 38, S38, 10.1016/S0168-8278(02)00429-4

Friedman, 2004, Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications, Nat Clin Pract Gastroenterol Hepatol, 1, 98, 10.1038/ncpgasthep0055

Bataller, 2005, Liver fibrosis, J Clin Invest, 115, 109, 10.1172/JCI24282

Friedman, 2008, Mechanisms of hepatic fibrogenesis, Gastroenterology, 134, 1655, 10.1053/j.gastro.2008.03.003

Parola, 2008, Myofibroblast-like cells in liver fibrogenesis: emerging concepts in a rapidly moving scenario, Mol Asp Med, 29, 58, 10.1016/j.mam.2007.09.002

Henderson, 2008, Hepatic fibrogenesis: from within and outwith, Toxicology, 254, 130, 10.1016/j.tox.2008.08.017

Kisseleva, 2008, Mechanisms of fibrogenesis, Exp Biol Med, 233, 109, 10.3181/0707-MR-190

Dranoff, 2010, Portal fibroblasts: underappreciated mediators of biliary fibrosis, Hepatology, 51, 1438, 10.1002/hep.23405

Pinzani, 2004, Liver fibrosis - from the bench to clinical targets, Dig Liver Dis, 36, 231, 10.1016/j.dld.2004.01.003

Cassiman, 2002, Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research, J Hepatol, 37, 527, 10.1016/S0168-8278(02)00263-5

Parola, 2009, Hepatic wound repair, Fibrogenesis & Tissue Repair, 2, 4, 10.1186/1755-1536-2-4

Cassiman, 2002, Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers, J Hepatol, 36, 200, 10.1016/S0168-8278(01)00260-4

Friedman, 2008, Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol Rev, 8, 125, 10.1152/physrev.00013.2007

Choi, 2009, Epithelial-to-mesenchymal transitions in the liver, Hepatology, 5, 2007, 10.1002/hep.23196

Cannito, 2010, Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease, Antioxid Redox Signal, 12, 1383, 10.1089/ars.2009.2737

Pinzani, 2001, Cytokine receptor and signalling in hepatic stellate cells, Sem Liv Dis, 21, 397, 10.1055/s-2001-17554

Novo, 2007, Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells, Am J Pathol, 170, 1942, 10.2353/ajpath.2007.060887

Novo, 2008, Redox mechanisms in hepatic chronic wound healing and liver fibrogenesis, Fibrogenesis & Tissue Repair, 1, 5, 10.1186/1755-1536-1-5

Novo, 2011, Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic profibrogenic cells, J Hepatol, 54, 964, 10.1016/j.jhep.2010.09.022

Schrader J, Gordon-Walker TT, Aucott RL, et al. Matrix stiffness modulates proliferation, chemotherapeutic response and dormancy in hepatocellular carcinoma cells. Hepatology. In press. doi:10.1002/hep.24108.

Medina, 2004, Angiogenesis in chronic inflammatory liver diseases, Hepatology, 39, 1185, 10.1002/hep.20193

Fernández, 2009, Angiogenesis in liver disease, J Hepatol, 50, 604, 10.1016/j.jhep.2008.12.011

Valfrè di Bonzo, 2009, Angiogenesis and liver fibrogenesis, Histol Histopathol, 24, 1323

Unanue, 2007, Ito cells, stellate cells, myofibroblasts: new actors in antigen presentation, Immunity, 26, 9, 10.1016/j.immuni.2007.01.001

Lorenzini, 2010, Characterization of a stereotypical cellular and extracellular adult LPC niche in rodents and diseased human liver, Gut, 59, 645, 10.1136/gut.2009.182345

Kordes, 2007, CD133+ hepatic stellate cells are progenitor cells, Biochem Biophys Res Commun, 352, 410, 10.1016/j.bbrc.2006.11.029

Yang, 2008, Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers, Stem Cells, 26, 2104, 10.1634/stemcells.2008-0115

Asahina, 2009, Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development, Hepatology, 49, 998, 10.1002/hep.22721

Clouston, 2005, Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis, Hepatology, 41, 809, 10.1002/hep.20650

Beaussier, 2007, Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries, Lab Invest, 87, 292, 10.1038/labinvest.3700513

Fabris, 2007, Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling, Am J Pathol, 171, 641, 10.2353/ajpath.2007.070073

Richardson, 2007, Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction, Gastroenterology, 133, 80, 10.1053/j.gastro.2007.05.012

Houlihan, 2008, Critical review of clinical trials of bone marrow stem cells in liver disease, Gastroenterology, 135, 438, 10.1053/j.gastro.2008.05.040

Baba, 2004, Commitment of bone marrow cells to hepatic stellate cells in mouse, J Hepatol, 40, 255, 10.1016/j.jhep.2003.10.012

Russo, 2006, The bone marrow functionally contributes to liver fibrosis, Gastroenterology, 130, 1807, 10.1053/j.gastro.2006.01.036

Fujimiya, 2009, Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver, Am J Physiol Gastrointest Liver Physiol, 297, G451, 10.1152/ajpgi.00055.2009

Asawa, 2007, Participation of bone marrow cells in biliary fibrosis after bile duct ligation, J Gastroenterol Hepatol, 22, 2001, 10.1111/j.1440-1746.2006.04708.x

Kisseleva, 2006, Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis, J Hepatol, 45, 429, 10.1016/j.jhep.2006.04.014

Forbes, 2004, A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis, Gastroenterology, 126, 955, 10.1053/j.gastro.2004.02.025

Dalakas, 2010, Bone marrow stem cells contribute to alcohol liver fibrosis in humans, Stem Cells Dev, 19, 1417, 10.1089/scd.2009.0387

Valfrè di Bonzo, 2008, Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential, Gut, 57, 223, 10.1136/gut.2006.111617

Higashiyama, 2009, Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice, Gastroenterology, 137, 1459, 10.1053/j.gastro.2009.07.006

Li, 2009, Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis, J Hepatol, 50, 1174, 10.1016/j.jhep.2009.01.028

Duffield, 2005, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair, J Clin Inves, 115, 56, 10.1172/JCI200522675

Karlmark, 2009, Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis, Hepatology, 50, 261, 10.1002/hep.22950

Karlmark, 2010, The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes, Hepatology, 52, 1769, 10.1002/hep.23894

Osterreicher, 2011, Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver, Proc Natl Acad Sci U S A, 108, 308, 10.1073/pnas.1017547108

Thiery, 2006, Complex networks orchestrate epithelial-mesenchymal transitions, Nat Rev Mol Cell Biol, 7, 131, 10.1038/nrm1835

Zeisberg, 2009, Biomarkers for epithelial-mesenchymal transitions, J Clin Invest, 119, 1429, 10.1172/JCI36183

Acloque, 2009, Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease, J Clin Invest, 119, 1438, 10.1172/JCI38019

Kalluri, 2009, The basics of epithelial-mesenchymal transition, J Clin Invest, 119, 1420, 10.1172/JCI39104

Zeisberg, 2007, Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition, J Biol Chem, 282, 23337, 10.1074/jbc.M700194200

Omenetti, 2008, Hedgehog signalling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans, J Clin Invest, 118, 3331

Choi, 2009, Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis, Am J Physiol Gastrointest Liver Physiol, 297, G1093, 10.1152/ajpgi.00292.2009

Taura, 2010, Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice, Hepatology, 51, 1027, 10.1002/hep.23368

Scholten, 2010, Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice, Gastroenterology, 139, 987, 10.1053/j.gastro.2010.05.005