Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis

Allen, 1996, APC of mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation, but not cytokine production, Int. Immunol., 147, 143, 10.1093/intimm/8.1.143 Allen, 1998, Profound suppression of cellular proliferation mediated by the secretions of nematodes, Parasite Immunol., 20, 241, 10.1046/j.1365-3024.1998.00151.x Borges, 1994, Efficacy of synthetic lipopeptide vaccines in the induction of cytotoxic T lymphocytes: comparison of the costimulating support provided by helper T cells and lipoamino acid, J. Immunol. Methods, 173, 253, 10.1016/0022-1759(94)90304-2 Chandrashekar, 1984, Separation of viable microfilariae free of blood cells on percoll gradients, J. Helminthol., 58, 69, 10.1017/S0022149X00028078 Corradin, 1993, Induction of macrophage nitric oxide production by interferon-gamma and tumor necrosis factor-alpha is enhanced by interleukin-10, Eur. J. Immunol., 23, 2045, 10.1002/eji.1830230851 Cunha, 1992, Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages, Biochem. Biophys. Res. Commun., 182, 1155, 10.1016/0006-291X(92)91852-H Devereux, 1984, A comprehensive set of sequencing analysis programs for the VAX, Nucleic Acids Res., 12, 387, 10.1093/nar/12.1Part1.387 Franková, 1998, IFN-γ-induced TNF-α is a prerequisite for in vitro production of nitric oxide generated in murine peritoneal macrophages by IFN-γ, Eur. J. Immunol., 28, 838, 10.1002/(SICI)1521-4141(199803)28:03<838::AID-IMMU838>3.0.CO;2-T Garraud, 1995, Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies, J. Immunol., 155, 1316, 10.4049/jimmunol.155.3.1316 Harnett, 1999, Phosphorylcholine: friend or foe of the immune system?, Immunol. Today, 20, 125, 10.1016/S0167-5699(98)01419-4 Hartmann, 1997, A filarial cystein protease inhibitor downregulates T-cell proliferation and induces interleukin-10 production, Eur. J. Immunol., 27, 2253, 10.1002/eji.1830270920 Hoffmann, 2000, Litomosoides sigmodontis in mice: reappraisal of an old model for filarial research, Parasitol. Today, 16, 387, 10.1016/S0169-4758(00)01738-5 Hoffmann, 2001, Determinants for resistance and susceptibility to microfilaraemia in Litomosoides sigmodontis filariasis, Parasitology, 122, 641, 10.1017/S0031182001007892 Lawrence, 1994, Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB/c mice, J. Immunol., 153, 1216, 10.4049/jimmunol.153.3.1216 Lustigman, 1992, Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus, J. Biol. Chem., 267, 17339, 10.1016/S0021-9258(18)41931-X Mabbott, 1995, Suppressor macrophages in Trypanosoma brucei infection: nitric oxide is related to both suppressive activity and lifespan in vivo, Parasite Immunol., 17, 143, 10.1111/j.1365-3024.1995.tb01016.x Maizels, 1993, Immunological modulation and evasion by helminth parasites in human populations, Nature, 365, 797, 10.1038/365797a0 Manoury, 2001, Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing, Curr. Biol., 11, 447, 10.1016/S0960-9822(01)00118-X Maréchal, 1996, The fate of the filaria Litomosoides sigmodontis in susceptible and naturally resistant mice, Parasite, 3, 25, 10.1051/parasite/1996031025 Ottesen, 1984, Immunological aspects of lymphatic filariasis and onchocerciasis in man, Trans. R. Soc. Trop. Med. Hyg., 78, 9, 10.1016/0035-9203(84)90309-2 Petit, 1992, Maturation of the filaria Litomosoides sigmodontis in BALB/c mice: comparative susceptibility of nine other inbred strains, Ann. Parasitol. Hum. Comp., 67, 144, 10.1051/parasite/1992675144 Pfaff, 2000, Litomosoides sigmodontis: dynamics of the survival of microfilariae in resistant and susceptible strains of mice, Exp. Parasitol., 94, 67, 10.1006/expr.1999.4475 Pfaff, 2000, The role of nitric oxide in the innate resistance to microfilariae of Litomosoides sigmodontis in mice, Parasite Immunol., 22, 397, 10.1046/j.1365-3024.2000.00317.x Schägger, 1987, Tricine-sodium dodecyl sulphate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa, Anal. Biochem., 166, 368, 10.1016/0003-2697(87)90587-2 Schönemeyer, 2001, Modulation of human T-cell responses and macrophage functions by onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus, J. Immunol., 167, 3207, 10.4049/jimmunol.167.6.3207 Soboslay, 1991, Experimental onchocerciasis in chimpanzees. Cell-mediated immune responses, and production and effects of IL-1 and IL-2 with Onchocerca volvulus infection, J. Immunol., 147, 346, 10.4049/jimmunol.147.1.346 Verdot, 1996, Cystatins up-regulate nitric oxide release from interferon-γ activated mouse peritoneal macrophages, J. Biol. Chem., 271, 28077, 10.1074/jbc.271.45.28077 Verdot, 1999, Chicken cystatin stimulates nitric oxide release from interferon-γ-activated mouse peritoneal macrophages via cytokine synthesis, Eur. J. Biochem., 266, 1111, 10.1046/j.1432-1327.1999.00964.x Von Heijne, 1986, A new method of predicting signal sequence cleavage sites, Nucleic Acids Res., 14, 4683, 10.1093/nar/14.11.4683