Literature review: Imaging in prostate cancer

Current Problems in Cancer - Tập 47 - Trang 100968 - 2023
Clemens Mingels1, Laura I. Loebelenz2, Adrian T. Huber2, Ian Alberts1, Axel Rominger1, Ali Afshar-Oromieh1, Verena C. Obmann2
1Department of Nuclear Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
2Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Bern, Switzerland

Tài liệu tham khảo

Sung, 2021, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA: Cancer J Clin, 71, 209 Yadav, 2018, Intratumor heterogeneity in prostate cancer, Urol Oncol, 36, 349, 10.1016/j.urolonc.2018.05.008 Ghafoor, 2019, Multimodality imaging of prostate cancer, J Nucl Med, 60, 1350, 10.2967/jnumed.119.228320 Parker, 2020, Prostate cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up†, Ann Oncol, 31, 1119, 10.1016/j.annonc.2020.06.011 Santos, 2022, Prostate cancer imaging: What we already know and what is on the horizon, Radiographics, 42, E123, 10.1148/rg.210134 Nörenberg, 2017, [MRI of the prostate], Urologe A, 56, 665, 10.1007/s00120-017-0378-4 Turkbey, 2019, Prostate imaging reporting and data system Version 2.1: 2019 update of prostate imaging reporting and data system version 2, Eur Urol, 76, 340, 10.1016/j.eururo.2019.02.033 Giganti, 2019, The evolution of MRI of the prostate: The past, the present, and the future, AJR Am J Roentgenol, 213, 384, 10.2214/AJR.18.20796 Bjurlin, 2020, Update of the standard operating procedure on the use of multiparametric magnetic resonance imaging for the diagnosis, staging and management of prostate cancer, J Urol, 203, 706, 10.1097/JU.0000000000000617 Rawla, 2019, Epidemiology of prostate cancer, World J Oncol, 10, 63, 10.14740/wjon1191 Gandaglia, 2021, Epidemiology and prevention of prostate cancer, Eur Urol Oncol, 4, 877, 10.1016/j.euo.2021.09.006 Rouvière, 2019, Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): A prospective, multicentre, paired diagnostic study, Lancet Oncol, 20, 100, 10.1016/S1470-2045(18)30569-2 O'Connor, 2021, Role of multiparametric prostate MRI in the management of prostate cancer, World J Urol, 39, 651, 10.1007/s00345-020-03310-z Herrmann, 2022, [Multiparametric MRI of the prostate], Urologe A, 61, 428, 10.1007/s00120-022-01806-7 Vargas, 2011, Diffusion-weighted endorectal MR imaging at 3 T for prostate cancer: tumor detection and assessment of aggressiveness, Radiology, 259, 775, 10.1148/radiol.11102066 Wu, 2017, Correlation between apparent diffusion coefficient value on diffusion-weighted MR imaging and Gleason score in prostate cancer, Diagn Interv Imaging, 98, 63, 10.1016/j.diii.2016.08.009 Anwar, 2014, Assessment of apparent diffusion coefficient values as predictor of aggressiveness in peripheral zone prostate cancer: comparison with Gleason score, ISRN Radiol, 2014, 10.1155/2014/263417 Franiel, 2021, mpMRI of the Prostate (MR-Prostatography): Updated recommendations of the DRG and BDR on patient preparation and scanning protocol, Rofo, 193, 763 Tsai, 2015, A practical guide to MR imaging safety: what radiologists need to know, Radiographics, 35, 1722, 10.1148/rg.2015150108 Obmann, 2018, Diagnostic accuracy of a rapid biparametric MRI protocol for detection of histologically proven prostate cancer, Urology, 122, 133, 10.1016/j.urology.2018.08.032 Kuhl, 2017, Abbreviated biparametric Prostate MR imaging in men with elevated prostate-specific antigen, Radiology, 285, 493, 10.1148/radiol.2017170129 Woo, 2018, Head-to-head comparison between biparametric and multiparametric MRI for the diagnosis of prostate cancer: A systematic review and meta-analysis, Am J Roentgenol, 211, W226, 10.2214/AJR.18.19880 Niu, 2018, Diagnostic performance of biparametric MRI for Detection of prostate cancer: A systematic review and meta-analysis, AJR Am J Roentgenol, 211, 369, 10.2214/AJR.17.18946 Kang, 2019, Abbreviated biparametric versus standard multiparametric MRI for diagnosis of prostate cancer: A systematic review and meta-analysis, AJR Am J Roentgenol, 212, 357, 10.2214/AJR.18.20103 Schoots, 2021, PI-RADS committee position on MRI without contrast medium in biopsy-naive men with suspected prostate cancer: Narrative review, AJR Am J Roentgenol, 216, 3, 10.2214/AJR.20.24268 Scialpi, 2020, Round table: arguments in supporting abbreviated or biparametric MRI of the prostate protocol, Abdom Radiol (NY), 45, 3974, 10.1007/s00261-020-02510-w Belue MJ, Yilmaz EC, Daryanani A, Turkbey B. Current status of biparametric MRI in prostate cancer diagnosis: literature analysis. Life (Basel). 2022;12. doi:10.3390/life12060804. Boesen, 2018, Assessment of the diagnostic accuracy of biparametric magnetic resonance imaging for prostate cancer in biopsy-naive men: The Biparametric MRI for Detection of Prostate Cancer (BIDOC) study, JAMA Network Open, 1, 10.1001/jamanetworkopen.2018.0219 Ahmed, 2017, Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): A paired validating confirmatory study, Lancet (London, England), 389, 815, 10.1016/S0140-6736(16)32401-1 Kasivisvanathan, 2018, MRI-targeted or standard biopsy for prostate-cancer diagnosis, N Engl J Med, 378, 1767, 10.1056/NEJMoa1801993 Stempel, 2020, MRI in the management of prostate cancer, Semin Ultrasound, CT, MR, 41, 366, 10.1053/j.sult.2020.04.003 Sebesta, 2017, The surgical management of prostate cancer, Semin Oncol, 44, 347, 10.1053/j.seminoncol.2018.01.003 Schlemmer, 2017, Multiparametrische MR-Bildgebung beim Prostatakarzinom, Radiologie up2date, 17, 43, 10.1055/s-0042-122604 Gupta, 2016, Multiparametric prostate MRI: focus on T2-weighted imaging and role in staging of prostate cancer, Abdom Radiol (NY), 41, 831, 10.1007/s00261-015-0579-5 Dickinson, 2011, Magnetic resonance imaging for the detection, localisation, and characterisation of prostate cancer: recommendations from a European consensus meeting, Eur Urol, 59, 477, 10.1016/j.eururo.2010.12.009 Caglic, 2019, Multiparametric MRI - local staging of prostate cancer and beyond, Radiol Oncol, 53, 159, 10.2478/raon-2019-0021 Gatti, 2022, mEPE-score: a comprehensive grading system for predicting pathologic extraprostatic extension of prostate cancer at multiparametric magnetic resonance imaging, Eur Radiol, 32, 4942, 10.1007/s00330-022-08595-9 Ucar, 2022, Comparison of 68Ga-PSMA PET/CT and mp-MRI in regard to local staging for prostate cancer with histopathological results: A retrospective study, Prostate, 82, 1462, 10.1002/pros.24420 Zhang, 2021, (68)Ga-PSMA PET/CT targeted biopsy for the diagnosis of clinically significant prostate cancer compared with transrectal ultrasound guided biopsy: a prospective randomized single-centre study, Eur J Nucl Med Mole Imaging, 48, 483, 10.1007/s00259-020-04863-2 Seyfried, 2021, Diagnostic yield of incremental biopsy cores and second lesion sampling for in-gantry MRI-guided prostate biopsy, AJR Am J Roentgenol, 217, 908, 10.2214/AJR.20.24918 Bohn, 2021, PSMA-Ligand uptake in disseminated epidermoid cysts in a PSMA PET/CT of a patient with recurrent prostate cancer, Clin Nucl Med, 46, e598, 10.1097/RLU.0000000000003749 Mingels, 2021, The influence of colour scale in lesion detection and patient-based sensitivity in [68Ga]Ga-PSMA-PET/CT, Nucl Med Commun, 42, 495, 10.1097/MNM.0000000000001364 Alberts, 2020, The role of additional late PSMA-ligand PET/CT in the differentiation between lymph node metastases and ganglia, Eur J Nucl Med Mole Imaging, 47, 642, 10.1007/s00259-019-04552-9 Rowe, 2018, PSMA-RADS Version 1.0: A step towards standardizing the interpretation and reporting of PSMA-targeted PET imaging studies, Eur Urol, 73, 485, 10.1016/j.eururo.2017.10.027 Shetty, 2018, Pitfalls in gallium-68 PSMA PET/CT interpretation: A pictorial review, Tomography, 4, 182, 10.18383/j.tom.2018.00021 Evangelista, 2021, PET/MRI in prostate cancer: A systematic review and meta-analysis, Eur J Nucl Med Mole Imaging, 48, 859, 10.1007/s00259-020-05025-0 Murthy, 2021, The Role of PSMA PET/CT and PET/MRI in the initial staging of prostate cancer, Eur Urol Focus, 7, 258, 10.1016/j.euf.2021.01.016 Mayerhoefer, 2020, PET/MRI versus PET/CT in oncology: A prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations, Eur J Nucl Med Mole Imaging, 47, 51, 10.1007/s00259-019-04452-y Yablon, 2004, Complications of prostate cancer treatment: Spectrum of imaging findings, Radiographics, 24, S181, 10.1148/rg.24si045502 Bedir, 2019, Diagnosis and conservative management of ureteral orifice injury during robotic prostatectomy for a large prostate with a prominent median lobe, J Endourol Case Rep, 5, 39, 10.1089/cren.2018.0109 Rahnama'i, 2021, Current management of post-radical prostatectomy urinary incontinence, Front Surg, 8, 10.3389/fsurg.2021.647656 Saleh, 2015, Management of erectile dysfunction post-radical prostatectomy, Res Rep Urol, 7, 19 Mohsen, 2022, Role of MRI, ultrasound, and computed tomography in the management of prostate cancer, PET Clin, 17, 565, 10.1016/j.cpet.2022.07.002 Ross, 2012, Do adenocarcinomas of the prostate with Gleason score (GS) ≤6 have the potential to metastasize to lymph nodes?, Am J Surg Pathol, 36, 1346, 10.1097/PAS.0b013e3182556dcd Meijer, 2022, The prognostic value of lymph node staging with prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) and extended pelvic lymph node dissection in node-positive patients with prostate cancer, BJU Int Hövels, 2008, The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis, Clin Radiol, 63, 387, 10.1016/j.crad.2007.05.022 Torabi, 2004, Current concepts in lymph node imaging, J Nucl Med, 45, 1509 von Below, 2016, Validation of 3 T MRI including diffusion-weighted imaging for nodal staging of newly diagnosed intermediate- and high-risk prostate cancer, Clin Radiol, 71, 328, 10.1016/j.crad.2015.12.001 Thoeny, 2017, Functional and targeted lymph node imaging in prostate cancer: Current status and future challenges, Radiology, 285, 728, 10.1148/radiol.2017161517 Evangelista, 2013, Utility of choline positron emission tomography/computed tomography for lymph node involvement identification in intermediate- to high-risk prostate cancer: a systematic literature review and meta-analysis, Eur Urol, 63, 1040, 10.1016/j.eururo.2012.09.039 Selnæs, 2018, (18)F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients, Eur Radiol, 28, 3151, 10.1007/s00330-017-5213-1 Mottet, 2021, EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, diagnosis, and local treatment with curative intent, Eur Urol, 79, 243, 10.1016/j.eururo.2020.09.042 Hofman, 2020, Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study, The Lancet, 395, 1208, 10.1016/S0140-6736(20)30314-7 Giesel, 2017, F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients, Eur J Nucl Med Mole Imaging, 44, 678, 10.1007/s00259-016-3573-4 Pienta, 2021, A Phase 2/3 prospective multicenter study of the diagnostic accuracy of prostate specific membrane antigen PET/CT with (18)F-DCFPyL in Prostate Cancer Patients (OSPREY), J Urol, 206, 52, 10.1097/JU.0000000000001698 Padhani, 2017, Rationale for modernising imaging in advanced prostate cancer, Eur Urol Focus, 3, 223, 10.1016/j.euf.2016.06.018 Sweeney, 2015, Chemohormonal therapy in metastatic hormone-sensitive prostate cancer, N Engl J Med, 373, 737, 10.1056/NEJMoa1503747 Larbi, 2016, Whole body MRI (WB-MRI) assessment of metastatic spread in prostate cancer: Therapeutic perspectives on targeted management of oligometastatic disease, Prostate, 76, 1024, 10.1002/pros.23196 Nakanishi, 2022, Whole-body MRI: detecting bone metastases from prostate cancer, Jpn J Radiol, 40, 229, 10.1007/s11604-021-01205-6 Padhani, 2017, METastasis reporting and data system for prostate cancer: Practical guidelines for acquisition, interpretation, and reporting of whole-body magnetic resonance imaging-based evaluations of multiorgan involvement in advanced prostate cancer, Eur Urol, 71, 81, 10.1016/j.eururo.2016.05.033 Barentsz, 2017, Assessing metastatic disease in advanced prostate cancer: It's time to change imaging, Eur Urol, 71, 93, 10.1016/j.eururo.2016.08.045 Donohoe, 2017, Appropriate use criteria for bone scintigraphy in prostate and breast cancer: Summary and excerpts, J Nucl Med, 58, 14n Fleury, 2018, Advantages of systematic trunk SPECT/CT to planar bone scan (PBS) in more than 300 patients with breast or prostate cancer, Oncotarget, 9, 31744, 10.18632/oncotarget.25860 Bénard, 2022, Intra-individual comparison of (18)F-sodium fluoride PET-CT and (99m)Tc bone scintigraphy with SPECT in patients with prostate cancer or breast cancer at high risk for skeletal metastases (MITNEC-A1): a multicentre, phase 3 trial, Lancet Oncol, 23, 1499, 10.1016/S1470-2045(22)00642-8 Armstrong, 2018, Phase 3 assessment of the automated bone scan index as a prognostic imaging biomarker of overall survival in men with metastatic castration-resistant prostate cancer: A secondary analysis of a randomized clinical trial, JAMA Oncol, 4, 944, 10.1001/jamaoncol.2018.1093 Hofman, 2020, Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study, Lancet (London, England), 395, 1208, 10.1016/S0140-6736(20)30314-7 Pyka, 2016, Comparison of bone scintigraphy and (68)Ga-PSMA PET for skeletal staging in prostate cancer, Eur J Nucl Med Mole Imaging, 43, 2114, 10.1007/s00259-016-3435-0 Fendler, 2023, PSMA PET/CT: joint EANM procedure guideline/SNMMI procedure standard for prostate cancer imaging 2.0, Eur J Nucl Med Mole Imaging, 50, 1466, 10.1007/s00259-022-06089-w Anttinen, 2021, Eur Urol Oncol, 4, 635, 10.1016/j.euo.2020.06.012 Grünig, 2021, Focal unspecific bone uptake on [(18)F]-PSMA-1007 PET: a multicenter retrospective evaluation of the distribution, frequency, and quantitative parameters of a potential pitfall in prostate cancer imaging, Eur J Nucl Med Mole Imaging, 48, 4483, 10.1007/s00259-021-05424-x Vollnberg, 2022, Assessment of malignancy and PSMA expression of uncertain bone foci in [(18)F]PSMA-1007 PET/CT for prostate cancer-a single-centre experience of PET-guided biopsies, Eur J Nucl Med Mole Imaging, 49, 3910, 10.1007/s00259-022-05745-5 Rao, 2019, Oligometastatic prostate cancer: A shrinking subset or an opportunity for cure?, Am Soc Clin Oncol Educ Book, 39, 309, 10.1200/EDBK_239041 Hicks, 2017, Seduction by sensitivity: Reality, illusion, or delusion? the challenge of assessing outcomes after PSMA imaging selection of patients for treatment, J Nucl Med, 58, 1969, 10.2967/jnumed.117.198812 Pisansky, 2019, Adjuvant and salvage radiotherapy after prostatectomy: ASTRO/AUA Guideline Amendment 2018-2019, J Urol, 202, 533, 10.1097/JU.0000000000000295 Lowrance, 2021, Advanced prostate cancer: AUA/ASTRO/SUO Guideline PART I, J Urol, 205, 14, 10.1097/JU.0000000000001375 Briganti, 2014, Prediction of outcome following early salvage radiotherapy among patients with biochemical recurrence after radical prostatectomy, Eur Urol, 66, 479, 10.1016/j.eururo.2013.11.045 Cornford, 2021, EAU-EANM-ESTRO-ESUR-SIOG Guidelines on prostate cancer. Part II-2020 Update: Treatment of relapsing and metastatic prostate cancer, Eur Urol, 79, 263, 10.1016/j.eururo.2020.09.046 Pucar, 2008, The role of imaging in the detection of prostate cancer local recurrence after radiation therapy and surgery, Curr Opin Urol, 18, 87, 10.1097/MOU.0b013e3282f13ac3 Panebianco, 2021, Prostate Magnetic Resonance Imaging for Local Recurrence Reporting (PI-RR): international consensus -based guidelines on multiparametric magnetic resonance imaging for prostate cancer recurrence after radiation therapy and radical prostatectomy, Eur Urol Oncol, 4, 868, 10.1016/j.euo.2021.01.003 Afshar-Oromieh A, Avtzi E, Giesel FL, et al. The diagnostic value of PET/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. European journal of nuclear medicine and molecular imaging. 2015;42:197-209. doi:10.1007/s00259-014-2949-6. Afshar-Oromieh A, Vollnberg B, Alberts I, et al. Comparison of PSMA-ligand PET/CT and multiparametric MRI for the detection of recurrent prostate cancer in the pelvis. European journal of nuclear medicine and molecular imaging. 2019;46:2289-97. doi:10.1007/s00259-019-04438-w. Alberts, 2021, Combination of forced diuresis with additional late imaging in 68Ga-PSMA-11 PET/CT – effects on lesion visibility and radiotracer uptake, J Nucl Med, 62, 1252, 10.2967/jnumed.120.257741 Afshar-Oromieh, 2021, Performance of [(68)Ga]Ga-PSMA-11 PET/CT in patients with recurrent prostate cancer after prostatectomy-a multi-centre evaluation of 2533 patients, Eur J Nucl Med Mole Imaging, 48, 2925, 10.1007/s00259-021-05189-3 Mingels, 2022, Diagnostic accuracy of [(18)F]PSMA-1007 PET/CT in biochemical recurrence of prostate cancer, Eur J Nucl Med Mole Imaging, 49, 2436, 10.1007/s00259-022-05693-0 Alberts, 2022, Comparing the clinical performance and cost efficacy of [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 in the diagnosis of recurrent prostate cancer: A Markov chain decision analysis, Eur J Nucl Med Mole Imaging, 49, 4252, 10.1007/s00259-021-05620-9 Alberts, 2021, Feasibility of late acquisition [68Ga]Ga-PSMA-11 PET/CT using a long axial field-of-view PET/CT scanner for the diagnosis of recurrent prostate cancer-first clinical experiences, Eur J Nucl Med Mole Imaging, 48, 4456, 10.1007/s00259-021-05438-5 Alberts, 2020, Digital versus analogue PET in [(68)Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: A matched-pair comparison, Eur J Nucl Med Mole Imaging, 47, 614, 10.1007/s00259-019-04630-y Mingels, 2023, Impact of the new ultra-high sensitivity mode in a long axial field-of-view PET/CT, Ann Nucl Med, 37, 310, 10.1007/s12149-023-01827-y Alberts, 2021, Clinical performance of long axial field of view PET/CT: A head-to-head intra-individual comparison of the Biograph Vision Quadra with the Biograph Vision PET/CT, Eur J Nucl Med Mole Imaging, 48, 2395, 10.1007/s00259-021-05282-7 Alberts, 2021, Digital PET/CT allows for shorter acquisition protocols or reduced radiopharmaceutical dose in [(18)F]-FDG PET/CT, Ann Nucl Med, 35, 485, 10.1007/s12149-021-01588-6 Sachpekidis, 2022, Application of the long axial field-of-view PET/CT with low-dose [(18)F]FDG in melanoma, Eur J Nucl Med Mole Imaging, 50, 1158, 10.1007/s00259-022-06070-7 Triumbari, 2023, Long axial field-of-view PET/CT could answer unmet needs in gynecological cancers, Cancers, 15, 2407, 10.3390/cancers15092407 Daryanani, 2022, Recent advancements in CT and MR imaging of prostate cancer, Semin Nucl Med, 52, 365, 10.1053/j.semnuclmed.2021.11.013 Gordon, 2020, Exploratory cost-effectiveness analysis of 68Gallium-PSMA PET/MRI-based imaging in patients with biochemical recurrence of prostate cancer, Clin Exp Metastasis, 37, 305, 10.1007/s10585-020-10027-1 Alberts, 2022, Afshar-Oromieh A. A randomised, prospective and head-to-head comparison of [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 for the detection of recurrent prostate cancer in PSMA-ligand PET/CT-Protocol design and rationale, PLoS One, 17, 10.1371/journal.pone.0270269 Pattison, 2022, Prospective intra-individual blinded comparison of [(18)F]PSMA-1007 and [(68) Ga]Ga-PSMA-11 PET/CT imaging in patients with confirmed prostate cancer, Eur J Nucl Med Mol Imaging, 49, 763, 10.1007/s00259-021-05520-y Alberts, 2021, Comparing the diagnostic performance of radiotracers in recurrent prostate cancer: a systematic review and network meta-analysis, Eur J Nucl Med Mol Imaging, 48, 2978, 10.1007/s00259-021-05210-9 Alberts, 2020, Afshar-Oromieh A. PSMA-negative prostate cancer and the continued value of choline-PET/CT, Nuklearmedizin, 59, 33, 10.1055/a-1044-1855 Iravani, 2021, Molecular imaging of neuroendocrine differentiation of prostate cancer: A case series, Clin Genitourin Cancer, 19, e200, 10.1016/j.clgc.2021.01.008 Fech, 2019, PSMA-ligand PET allows a more accurate therapeutic response evaluation of bone metastases in prostate cancer compared to computed tomography, Nuklearmedizin Cysouw, 2019, Sensitivity of 18F-fluorodihydrotestosterone PET-CT to count statistics and reconstruction protocol in metastatic castration-resistant prostate cancer, EJNMMI Res, 9, 70, 10.1186/s13550-019-0531-8 Fox, 2018, Positron Emission Tomography/Computed Tomography–based assessments of androgen receptor expression and glycolytic activity as a prognostic biomarker for metastatic castration-resistant prostate cancer, JAMA Oncol, 4, 217, 10.1001/jamaoncol.2017.3588 Alberts, 2022, Afshar-Oromieh A. Combined [68 Ga]Ga-PSMA-11 and low-dose 2-[18F]FDG PET/CT using a long-axial field of view scanner for patients referred for [177Lu]-PSMA-radioligand therapy, European J Nucl Med Mole Imaging Cheng, 2012, Staging of prostate cancer, Histopathology, 60, 87, 10.1111/j.1365-2559.2011.04025.x