Lipoprotein(a) and proprotein convertase subtilisin/kexin type 9 inhibitors

Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM et al (2018) NHLBI working group recommendations to reduce lipoprotein(a)-mediated risk of cardiovascular disease and aortic stenosis. J Am Coll Cardiol 71(2):177–192. https://doi.org/10.1016/j.jacc.2017.11.014

Sharma M, Redpath GM, Williams MJ, McCormick SP (2017) Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a). Circ Res 120(7):1091–1102. https://doi.org/10.1161/CIRCRESAHA.116.310272

Schulz R, Schluter KD (2017) PCSK9 targets important for lipid metabolism. Clin Res Cardiol Suppl. https://doi.org/10.1007/s11789-017-0085-0

Reyes-Soffer G, Pavlyha M, Ngai C, Thomas T, Holleran S, Ramakrishnan R et al (2017) Effects of PCSK9 inhibition with alirocumab on lipoprotein metabolism in healthy humans. Circulation 135(4):352–362. https://doi.org/10.1161/CIRCULATIONAHA.116.025253

Tsimikas S (2017) A test in context: lipoprotein(a): diagnosis, prognosis, controversies, and emerging therapies. J Am Coll Cardiol 69(6):692–711. https://doi.org/10.1016/j.jacc.2016.11.042

Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS et al (2005) Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med 353(1):46–57. https://doi.org/10.1056/NEJMoa043175

Tavori H, Christian D, Minnier J, Plubell D, Shapiro MD, Yeang C et al (2016) PCSK9 association with lipoprotein(a). Circ Res 119(1):29–35. https://doi.org/10.1161/CIRCRESAHA.116.308811

Nave AH, Lange KS, Leonards CO, Siegerink B, Doehner W, Landmesser U et al (2015) Lipoprotein (a) as a risk factor for ischemic stroke: a meta-analysis. Atherosclerosis 242(2):496–503

Langsted A, Kamstrup PR, Nordestgaard BG (2019) High lipoprotein(a) and high risk of mortality. Eur Heart J. https://doi.org/10.1093/eurheartj/ehy902

Cao YX, Liu HH, Li S, Li JJ (2018) A Meta-analysis of the effect of PCSK9-monoclonal antibodies on circulating lipoprotein (a) levels. Am J Cardiovasc Drugs. https://doi.org/10.1007/s40256-018-0303-2

Watts GF, Chan DC, Somaratne R, Wasserman SM, Scott R, Marcovina SM et al (2018) Controlled study of the effect of proprotein convertase subtilisin-kexin type 9 inhibition with evolocumab on lipoprotein(a) particle kinetics. Eur Heart J 39(27):2577–2585. https://doi.org/10.1093/eurheartj/ehy122

Stiekema LCA, Stroes ESG, Verweij SL, Kassahun H, Chen L, Wasserman SM et al (2018) Persistent arterial wall inflammation in patients with elevated lipoprotein(a) despite strong low-density lipoprotein cholesterol reduction by proprotein convertase subtilisin/kexin type 9 antibody treatment. Eur Heart J. https://doi.org/10.1093/eurheartj/ehy862

Moriarty PM, Parhofer KG, Babirak SP, Cornier MA, Duell PB, Hohenstein B et al (2016) Alirocumab in patients with heterozygous familial hypercholesterolaemia undergoing lipoprotein apheresis: the ODYSSEY ESCAPE trial. Eur Heart J 37(48):3588–3595. https://doi.org/10.1093/eurheartj/ehw388

Giugliano RP, Pedersen TR, Park JG, De Ferrari GM, Gaciong ZA, Ceska R et al (2017) Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial. Lancet 390(10106):1962–1971. https://doi.org/10.1016/S0140-6736(17)32290-0

O’Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I et al (2018) Lipoprotein(a), PCSK9 inhibition and cardiovascular risk: insights from the FOURIER trial. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.118.037184

Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R et al (2018) Alirocumab and cardiovascular outcomes after acute coronary syndrome. N Engl J Med 379(22):2097–2107. https://doi.org/10.1056/NEJMoa1801174

Verbeek R, Hoogeveen RM, Langsted A, Stiekema LCA, Verweij SL, Hovingh GK et al (2018) Cardiovascular disease risk associated with elevated lipoprotein(a) attenuates at low low-density lipoprotein cholesterol levels in a primary prevention setting. Eur Heart J 39(27):2589–2596. https://doi.org/10.1093/eurheartj/ehy334

Willeit P, Ridker PM, Nestel PJ, Simes J, Tonkin AM, Pedersen TR et al (2018) Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials. Lancet 392(10155):1311–1320. https://doi.org/10.1016/S0140-6736(18)31652-0

Yeang C, Witztum JL, Tsimikas S (2015) ‘LDL-C’ = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol 26(3):169–178

Leebmann J, Roeseler E, Julius U, Heigl F, Spitthoever R, Heutling D et al (2013) Lipoprotein apheresis in patients with maximally tolerated lipid-lowering therapy, lipoprotein(a)-hyperlipoproteinemia, and progressive cardiovascular disease: prospective observational multicenter study. Circulation 128(24):2567–2576. https://doi.org/10.1161/CIRCULATIONAHA.113.002432

Roeseler E, Julius U, Heigl F, Spitthoever R, Heutling D, Breitenberger P et al (2016) Lipoprotein apheresis for lipoprotein(a)-associated cardiovascular disease: prospective 5 years of follow-up and apolipoprotein(a) characterization. Arterioscler Thromb Vasc Biol 36(9):2019–2027. https://doi.org/10.1161/ATVBAHA.116.307983

Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ et al (2016) Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet 388(10057):2239–2253. https://doi.org/10.1016/S0140-6736(16)31009-1