Lipopolysaccharide-Induced NF-κB Activation in Human Endothelial Cells Involves Degradation of IκBα but Not IκBβ

Experimental Cell Research - Tập 243 - Trang 425-433 - 1998
Katsuhiro Zen1, Aly Karsan2, Thomas Eunson1, Esther Yee1, John M. Harlan1
1Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, 98195
2Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada

Tài liệu tham khảo

Dixit, 1990, Tumor necrosis factor-α induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin, J. Biol. Chem., 265, 2973, 10.1016/S0021-9258(19)39896-5 Opipari, 1992, The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity, J. Biol. Chem., 267, 12424, 10.1016/S0021-9258(18)42292-2 Tewari, 1995, Lymphoid expression and regulation of A20, an inhibitor of programmed cell death, J. Immunol., 154, 1699, 10.4049/jimmunol.154.4.1699 Pohlman, 1989, Human endothelial cell response to lipopolysaccharide, interleukin-1, and tumor necrosis factor is regulated by protein synthesis, Cell. Immunol., 119, 41, 10.1016/0008-8749(89)90222-0 Polunovsky, 1994, Induction of endothelial cell apoptosis by TNF-α: Modulation by inhibitors of protein synthesis, Exp. Cell Res., 214, 584, 10.1006/excr.1994.1296 Cooper, 1996, A20 blocks endothelial cell activation through a NF-κB-dependent mechanism, J. Biol. Chem., 271, 18068, 10.1074/jbc.271.30.18068 Karsan, 1996, Endothelial cell death induced by tumor necrosis factor-α is inhibited by the Bcl-2 family member, A1, J. Biol. Chem., 271, 27201, 10.1074/jbc.271.44.27201 Jaattela, 1996, A20 zinc finger protein inhibits TNF and IL-1 signaling, J. Immunol., 156, 1166, 10.4049/jimmunol.156.3.1166 Song, 1996, The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation, Proc. Natl. Acad. Sci. USA, 93, 6721, 10.1073/pnas.93.13.6721 Vincenz, 1996, 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules, J. Biol. Chem., 271, 20029, 10.1074/jbc.271.33.20029 Baldwin, 1996, The NF-κB and IκB proteins: new discoveries and insights, Annu. Rev. Immunol., 14, 649, 10.1146/annurev.immunol.14.1.649 Read, 1994, NF-κB and IκBα: An inducible regulatory system in endothelial activation, J. Exp. Med., 179, 503, 10.1084/jem.179.2.503 Read, 1995, The proteasome pathway is required for cytokine-induced endothelial–leukocyte adhesion molecule expression, Immunity, 2, 493, 10.1016/1074-7613(95)90030-6 Roff, 1996, Role of IκBα ubiquitination in signal-induced activation of NF-κB in vivo, J. Biol. Chem., 271, 7844, 10.1074/jbc.271.13.7844 Hsu, 1995, The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation, Cell, 81, 495, 10.1016/0092-8674(95)90070-5 Hsu, 1996, TRADD–TRAF2 and TRADD–FADD interactions define two distinct TNF receptor 1 signal transduction pathways, Cell, 84, 299, 10.1016/S0092-8674(00)80984-8 Liu, 1996, Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death, Cell, 87, 565, 10.1016/S0092-8674(00)81375-6 Schutze, 1995, TNF-induced activation of NF-κB, Immunobiology, 193, 193, 10.1016/S0171-2985(11)80543-7 Arditi, 1993, Endotoxin-mediated endothelial cell injury and activation: Role of soluble CD14, Infect. Immun., 61, 3149, 10.1128/IAI.61.8.3149-3156.1993 Frey, 1992, Soluble CD14 participates in the response of cells to lipopolysaccharide, J. Exp. Med., 176, 1665, 10.1084/jem.176.6.1665 Haziot, 1993, Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide, J. Immunol., 151, 1500, 10.4049/jimmunol.151.3.1500 Arditi, 1995, J. Immunol., 155, 3994, 10.4049/jimmunol.155.8.3994 Schumann, 1996, Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14, Blood, 87, 2805, 10.1182/blood.V87.7.2805.bloodjournal8772805 Zen, 1994, Gene expression of monocyte chemoattractant protein-1 in human monocytes is regulated by cell density through protein tyrosine kinase and protein kinase C, Exp. Cell Res., 215, 172, 10.1006/excr.1994.1329 Montgomery, 1991, Activation of endothelial–leukocyte adhesion molecule 1 (ELAM-1) gene transcription, Proc. Natl. Acad. Sci. USA, 88, 6523, 10.1073/pnas.88.15.6523 Imbert, 1996, Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α, Cell, 86, 787, 10.1016/S0092-8674(00)80153-1 Krikos, 1992, Transcriptional activation of the tumor necrosis factor α-inducible zinc finger protein, A20, is mediated by κB elements, J. Biol. Chem., 267, 17971, 10.1016/S0021-9258(19)37138-8 Weber, 1995, Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules, J. Immunol., 155, 445, 10.4049/jimmunol.155.1.445 Tebo, 1994, Murine inhibitory protein-κBα negatively regulates κB-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages, J. Immunol., 153, 4713, 10.4049/jimmunol.153.10.4713 Johnson, 1996, A sustained reduction in IκB-β may contribute to persistent NF-κB activation in human endothelial cells, J. Biol. Chem., 271, 16317, 10.1074/jbc.271.27.16317 Beauparlant, 1996, The role of the C-terminal domain of IκBα in protein degradation and stabilization, J. Biol. Chem., 271, 10690, 10.1074/jbc.271.18.10690 Koong, 1994, Hypoxic activation of nuclear factor-κB is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2), Cancer Res., 54, 5273 Sweet, 1996, Endotoxin signal transduction in macrophages, J. Leukocyte Biol., 60, 8, 10.1002/jlb.60.1.8 Adamson, 1996, Protein tyrosine kinase inhibitors act downstream of IL-1α and LPS stimulated MAP-kinase phosphorylation to inhibit expression of E-selectin on human umbilical vein endothelial cells, Cell Adhes. Commun., 3, 511, 10.3109/15419069609081027 Cuenda, 1995, SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1, FEBS Lett., 364, 229, 10.1016/0014-5793(95)00357-F Pietersma, 1997, p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level, Biochem. Biophys. Res. Commun., 230, 44, 10.1006/bbrc.1996.5886 Waters, 1995, Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex, J. Biol. Chem., 270, 20883, 10.1074/jbc.270.36.20883 Bell, 1996, IκBγ inhibits DNA binding of NF-κB p50 homodimers by interacting with residues that contact DNA, Mol. Cell Biol., 16, 6477, 10.1128/MCB.16.11.6477 Thompson, 1995, IκB-β regulates the persistent response in a biophasic activation of NF-κB, Cell, 80, 573, 10.1016/0092-8674(95)90511-1 Marsh, 1994, IL-1ra suppresses endotoxin-induced IL-1β and TNF-α release from mononuclear phagocytes, Am. J. Physiol., 267, 39 Cobb, 1996, Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-κB, Eur. J. Immunol., 26, 839, 10.1002/eji.1830260417 Delude, 1994, CD14-mediated translocation of nuclear factor-κB induced by lipopolysaccharide does not require tyrosine kinase activity, J. Biol. Chem., 269, 22253, 10.1016/S0021-9258(17)31784-2 Mahon, 1995, Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-κB activation in T lymphocytes: Evidence for covalent modification of the p50 subunit, J. Biol. Chem., 270, 28557, 10.1074/jbc.270.48.28557 Takahashi, 1996, Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells: Essential role for a herbimycin-sensitive kinase, J. Clin. Invest., 98, 2623, 10.1172/JCI119083 Chen, 1996, Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity, Cell, 84, 853, 10.1016/S0092-8674(00)81064-8 Bennett, 1996, Identification of signal-induced IκB-α kinases in human endothelial cells, J. Biol. Chem., 271, 19680, 10.1074/jbc.271.33.19680 Janosch, 1996, Characterization of IκB kinases. IκB-α is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate, J. Biol. Chem., 271, 13868, 10.1074/jbc.271.23.13868 Sanghera, 1996, Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages, J. Immunol., 156, 4457, 10.4049/jimmunol.156.11.4457 Hirano, 1996, MEK kinase is involved in tumor necrosis factor α-induced NF-κB activation and degradation of IκB-α, J. Biol. Chem., 271, 13234, 10.1074/jbc.271.22.13234 Hambleton, 1996, Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages, Proc. Natl. Acad. Sci. USA, 93, 2774, 10.1073/pnas.93.7.2774 Modur, 1996, Endothelial cell inflammatory responses to tumor necrosis factor-α: Ceramide-dependent and -independent mitogen-activated protein kinase cascades, J. Biol. Chem., 271, 13094, 10.1074/jbc.271.22.13094 Cano, 1994, Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun, Mol. Cell Biol., 14, 7352, 10.1128/MCB.14.11.7352 Claudio, 1996, Molecular mechanisms of TNFα cytotoxicity: Activation of NF-κB and nuclear translocation, Exp. Cell Res., 224, 63, 10.1006/excr.1996.0111 Lee, 1997, Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway, Cell, 88, 213, 10.1016/S0092-8674(00)81842-5 Meyer, 1996, Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating κB enhancer activation, J. Biol. Chem., 271, 8971, 10.1074/jbc.271.15.8971 Malinin, 1997, MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1, Nature, 385, 540, 10.1038/385540a0 DiDonato, 1997, A cytokine-responsive IκB kinase that activates the transcription factor NF-κB, Nature, 388, 548, 10.1038/41493 R'egnier, 1997, Identification and characterization of an IκB kinase, Cell, 90, 373, 10.1016/S0092-8674(00)80344-X Fukazawa, 1994, Labeling of v-Src and BCR-ABL tyrosine kinases with [14, FEBS Lett., 340, 155, 10.1016/0014-5793(94)80127-4 Herrera, 1996, Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes, J. Immunol., 156, 1157, 10.4049/jimmunol.156.3.1157 Stefanova, 1993, Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn, J. Biol. Chem., 268, 20725, 10.1016/S0021-9258(19)36840-1 Meng, 1997, Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn, J. Exp. Med., 185, 1661, 10.1084/jem.185.9.1661