Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders

Phytomedicine - Tập 20 - Trang 143-147 - 2013
Tyler A. Johnson1,2, Johann Sohn1, Wayne D. Inman2, Leonard F. Bjeldanes1, Keith Rayburn3
1Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, United States
2Department of Chemistry & Biochemistry, University of California, Santa Cruz, CA 95064, United States
3Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, United States

Tài liệu tham khảo

Ahmed, 2005, Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis, Evidence-Based Complementary and Alternative Medicine, 2, 301, 10.1093/ecam/neh117 Broer, 2002, Immunosuppressant effect of IDS 30, a stinging nettle leaf extract, on myeloid dendritic cells in vitro, Journal of Rheumatology, 29, 659 Cameron, 2009, Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 1, Phytotherapy Research, 23, 1497, 10.1002/ptr.3007 Christensen, 2010, Is Phytalgic® a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment, Arthritis Research and Therapy, 12, R105, 10.1186/ar2909 Chrubasik, 1999, Treatment of rheumatic pain with kampo medicine in Europe. Part II. Urtica dioica, Pain Clinic, 11, 179 Chrubasik, 2007, A comprehensive review on nettle effect and efficacy profiles. Part I: Herba urticae, Phytomedicine, 14, 423, 10.1016/j.phymed.2007.03.004 Chrubasik, 2007, A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: Urticae radix, Phytomedicine, 14, 568, 10.1016/j.phymed.2007.03.014 Cummings, 2011, Mechanism of action of stinging nettles, Wilderness and Environmental Medicine, 22, 136, 10.1016/j.wem.2011.01.001 Goldman-Mansky, 2009, Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial, Annals of Internal Medicine, 51, 229, 10.7326/0003-4819-151-4-200908180-00005 Jacquet, 2009, Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomized double-blind placebo-controlled clinical trial, Arthritis Research and Therapy, 11, R192, 10.1186/ar2891 Ji, 2007, Chemical constituents of Urtica dioica L. grown in Tibet autonomous region, Zhong yao cai=Journal of Chinese Medicinal Materials, 30, 662 Johnson, 2010, Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products, Journal of Natural Products, 3, 359, 10.1021/np900565a Johnson, 2012, Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC–MS/ELSD libraries, Bioorganic and Medicinal Chemistry, 20, 4348, 10.1016/j.bmc.2012.05.043 Khanna, 2007, Natural products as a gold mine for arthritis treatment, Current Opinion in Pharmacology, 7, 344, 10.1016/j.coph.2007.03.002 Lee, 2006, Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid, Biochemical Pharmacology, 72, 1311, 10.1016/j.bcp.2006.08.014 Long, 2001, Herbal medicines for the treatment of osteoarthritis: a systematic review, Rheumatology, 40, 779, 10.1093/rheumatology/40.7.779 Ma, 2007, Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii, Phytochemistry, 68, 1172, 10.1016/j.phytochem.2007.02.021 Randall, 2008, Nettle sting for chronic knee pain: a randomized controlled pilot study, Complementary Therapies in Medicine, 16, 66, 10.1016/j.ctim.2007.01.012 Rayburn, 2009, Stinging nettle cream for osteoarthritis, Alternative Therapies in Health and Medicine, 15, 60 Riehemann, 1999, Plant extracts from stinging nettle (Urtica dioica), an anti-rheumatic remedy, inhibit the proinflammatory transcription factor NF-κB, FEBS Letters, 442, 89, 10.1016/S0014-5793(98)01622-6 Schulze-Tanzil, 2002, Effects of the antirheumatic remedy Hox alpha – a new stinging nettle leaf extract – on matrix metalloproteinases in human chondrocytes in vitro, Histology and Histopathology, 17, 477 Setty, 2005, Herbal medications: commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects, Seminars in Arthritis and Rheumatism, 34, 773, 10.1016/j.semarthrit.2005.01.011 Soeken, 2003, Herbal medicines for the treatment of rheumatoid arthritis: a systematic review, Rheumatology, 42, 652, 10.1093/rheumatology/keg183 Tao, 2002, Benefit of an extract of Tripterygium wilfordii hook F in patients with rheumatoid arthritis, Arthritis and Rheumatism, 7, 1735, 10.1002/art.10411 Venkatesha, 2011, Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis, Bioorganic and Medicinal Chemistry, 19, 21, 10.1016/j.bmc.2010.10.053 Venkatesha, 2011, Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses, Journal of Biological Chemistry, 17, 15138, 10.1074/jbc.M111.226365 Zhou, 2012, Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms, Natural Products Reports, 29, 457, 10.1039/c2np00088a