Lipopeptid như một chất chống nhiễm khuẩn: một góc nhìn thực tiễn
Tóm tắt
Kháng sinh lipopeptide đại diện cho một loại kháng sinh cũ đã được phát hiện cách đây hơn 50 năm, bao gồm cả polymyxin cũ nhưng cũng có những loại mới, chẳng hạn như daptomycin mới được phê duyệt. Chúng thường bao gồm một phần peptide vòng ưa nước gắn kết với một chuỗi axit béo, điều này giúp chúng chèn vào lớp lipid của màng tế bào vi khuẩn. Bài tổng quan này trình bày một cái nhìn tổng thể về loại kháng sinh này, tập trung vào các ứng dụng điều trị và đặc biệt nhấn mạnh các điều chỉnh hóa học được thực hiện để cải thiện hoạt tính của chúng.
Từ khóa
#lipopeptide #kháng sinh #ứng dụng điều trị #sửa đổi hóa họcTài liệu tham khảo
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