Lipid profile of childhood cancer survivors and the effects of vitamin D supplementation: a prospective study

Springer Science and Business Media LLC - Tập 69 - Trang 1-6 - 2021
Shaimaa Kandil1, Ashraf Fouda2, Khadijah Boujettif3, Yasmin Salama4, Suzy Abdelmabood5
1Pediatric Department, Faculty of Medicine, Mansoura University Children Hospital, Mansoura University, Al-Mansoura, Egypt
2Pediatric Oncology, Jeddah Oncology Center, King Abdullah Medical City, Makkah, Saudi Arabia
3University of Nicosia Medical School, Nicosia, Cyprus
4Mansoura International Specialized Hospital, Al-Mansoura, Egypt
5Pediatric Department, Pediatric Hematology and Oncology Unit, Faculty of Medicine, Oncology Center–Mansoura University, Al-Mansoura, Egypt

Tóm tắt

Childhood cancer survivors (CCS) have high prevalence of obesity vitamin D (VD) deficiency together with dyslipidemia. We aimed to evaluate lipid profile and the effect of VD supplementation in CCS. VD deficiency was more frequent among obese CCS and their lipid profiles, TC, and LDL-C levels were significantly higher compared to non-obese patients. After VD supplementation trials, VD levels increased among obese and non-obese children albeit it was significantly higher in non-obese subjects while the lipid profile of obese patients significantly decreased. Also, parathyroid hormone levels were persistently elevated among VD-deficient obese patients. Yet, the weight of obese patients remained unchanged. VD deficiency was more prevalent among obese CCS. VD supplementation helped in normalization of the lipid profile of obese CCS. Regular measurement of PTH and 25OH-VD is recommended for CCS especially obese ones who may need VD supplementation.

Tài liệu tham khảo

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