Linkage Disequilibrium and Gene Mapping: An Empirical Least-Squares Approach

Akaike, 1974, A new look at statistical model identification, IEEE Trans Automatic Control AU-, 19, 716, 10.1109/TAC.1974.1100705 Bengtsson, 1981, Measuring the strength of associations between HLA antigens and diseases, Tissue Antigens, 18, 356, 10.1111/j.1399-0039.1981.tb01404.x Devlin, 1995, A comparison of linkage disequilibrium measures for fine-scale mapping, Genomics, 29, 311, 10.1006/geno.1995.9003 Devlin, 1996, Disequilibrium mapping: composite likelihood for pairwise disequilibrium, Genomics, 36, 1, 10.1006/geno.1996.0419 Efron, 1979, Bootstrap methods: another look at the jackknife, Ann Stat, 7, 1, 10.1214/aos/1176344552 Efron, 1993 Goddard, 1996, Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers, Am J Hum Genet, 58, 1286 Hästbacka, 1994, The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping, Cell, 78, 1073, 10.1016/0092-8674(94)90281-X Hill, 1994, Maximum-likelihood estimation of gene location by linkage disequilibrium, Am J Hum Genet, 54, 705 Jorde, 1995, Linkage disequilibrium as a gene mapping tool, Am J Hum Genet, 56, 11 Kaplan, 1995, Likelihood methods for locating disease genes in nonequilibrium populations, Am J Hum Genet, 56, 18 Kerem, 1989, Identification of the cystic fibrosis gene: genetic analysis, Science, 245, 1073, 10.1126/science.2570460 Lazzeroni LC, Lange K. A conditional inference framework for extending the transmission/disequilibrium test. Hum Hered (in press). Lehesjoki, 1993, Localization of the EPM1 gene for progressive myoclonus epilepsy on chromosome 21: linkage disequilibrium allows high resolution mapping, Hum Mol Genet, 2, 1229, 10.1093/hmg/2.8.1229 Ott, 1991 Ramsay, 1993, Haplotype analysis to determine the position of a mutation among closely linked DNA markers, Hum Mol Genet, 2, 1007, 10.1093/hmg/2.7.1007 Seber, 1989 Terwilliger, 1995, A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci, Am J Hum Genet, 56, 777 Xiong, 1997, Fine-scale genetic mapping based on linkage disequilibrium: theory and applications, Am J Hum Genet, 60, 1513, 10.1086/515475