Linfocitos NKT invariantes: ontogenia, fenotipo y función

Makino, 1995, Predominant expression of invariant v alpha 14+ TCR alpha chain in NK1.1+ T cell populations, Int Immunol, 7, 1157, 10.1093/intimm/7.7.1157 Fowlkes, 1987, A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family, Nature, 329, 251, 10.1038/329251a0 Zlotnik, 1992, Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4, J Immunol, 149, 1211, 10.4049/jimmunol.149.4.1211 Onteki, 1994, Major histocompatibility complex class i related molecules control the development of CD4+8– and CD4–8– subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice, J Exp Med, 180, 699, 10.1084/jem.180.2.699 Bendelac, 1995, CD1 recognition by mouse NK1+ T lymphocytes, Science, 268, 863, 10.1126/science.7538697 Brigl, 2004, CD1: Antigen presentation and T cell function, Annu Rev Immunol, 22, 817, 10.1146/annurev.immunol.22.012703.104608 Kawano, 1997, CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides, Science, 278, 1626, 10.1126/science.278.5343.1626 Hayakawa, 2004, Alpha-galactosylceramide: Potential immunomodulatory activity and future application, Curr Med Chem, 11, 241, 10.2174/0929867043456115 Godfrey, 2004, NKT cells: What's in a name?, Nat Rev Immunol, 4, 231, 10.1038/nri1309 Montoya, 2007, Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11, Immunology, 122, 1, 10.1111/j.1365-2567.2007.02647.x Van den Heuvelm, 2011, NKT cell costimulation: Experimental progress and therapeutic promise, Trends Mol Med, 17, 65, 10.1016/j.molmed.2010.10.007 Egawa, 2005, Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors, Immunity, 22, 705, 10.1016/j.immuni.2005.03.011 Yassai, 2012, Developmental dynamics of post-selection thymic DN iNKT, PLoS One, 7, e43509, 10.1371/journal.pone.0043509 Dao, 2004, Development of CD1d-restricted NKT cells in the mouse thymus, Eur J Immunol, 34, 3542, 10.1002/eji.200425546 Bendelac, 1995, Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes, J Exp Med, 182, 2091, 10.1084/jem.182.6.2091 Li, 2009, Immunologic glycosphingolipidomics and NKT cell development in mouse thymus, J Proteome Res, 8, 2740, 10.1021/pr801040h Zhou, 2004, Lysosomal glycosphingolipid recognition by NKT cells, Science, 306, 1786, 10.1126/science.1103440 Brennan, 2011, Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals, Nat Immunol, 12, 1202, 10.1038/ni.2143 Sanderson, 2013, CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells, Eur J Immunol, 43, 815, 10.1002/eji.201242952 Godfrey, 2010, Antigen recognition by CD1d-restricted NKT T cell receptors, Semin Immunol, 22, 61, 10.1016/j.smim.2009.10.004 D’Cruz, 2010, Transcriptional regulation of NKT cell development and homeostasis, Curr Opin Immunol, 22, 199, 10.1016/j.coi.2010.01.014 Das, 2010, Transcriptional control of invariant NKT cell development, Immunol Rev, 238, 195, 10.1111/j.1600-065X.2010.00962.x Darmoise, 2010, Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells, Immunity, 33, 216, 10.1016/j.immuni.2010.08.003 Engel, 2012, Making memory at birth: understanding the differentiation of natural killer T cells, Curr Opin Immunol, 24, 184, 10.1016/j.coi.2012.01.012 Berzins, 2005, Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples, Eur J Immunol, 35, 1399, 10.1002/eji.200425958 Hu, 2011, Control of early stages in invariant natural killer T-cell development, Immunology, 134, 1, 10.1111/j.1365-2567.2011.03463.x Benlagha, 2002, A thymic precursor to the NK T cell lineage, Science, 296, 553, 10.1126/science.1069017 Pellicci, 2002, A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(–)CD4(+) CD1d-dependent precursor stage, J Exp Med, 195, 835, 10.1084/jem.20011544 Berzins, 2006, Long-term retention of mature NK1.1+ NKT cells in the thymus, J Immunol, 176, 4059, 10.4049/jimmunol.176.7.4059 Pellicci, 2003, Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide, Eur J Immunol, 33, 1816, 10.1002/eji.200323894 Chun, 2003, CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells, J Exp Med, 197, 907, 10.1084/jem.20021366 Wang, 2010, The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells, Eur J Immunol, 40, 2385, 10.1002/eji.201040534 Kinjo, 2006, Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria, Nat Immunol, 7, 978, 10.1038/ni1380 Shiratsuchi, 2009, Human CD1 dimeric proteins as indispensable tools for research on CD1-binding lipids and CD1-restricted T cells, J Immunol Method, 345, 49, 10.1016/j.jim.2009.04.002 Van Kaer, 2004, Regulation of immune responses by CD1d-restricted natural killer T cells, Immunol Res, 30, 139, 10.1385/IR:30:2:139 Bienemann, 2011, iNKT cell frequency in peripheral blood of Caucasian children and adolescent: The absolute iNKT cell count is stable from birth to adulthood, Scand J Immunol, 74, 406, 10.1111/j.1365-3083.2011.02591.x Peralbo, 2007, Invariant NKT and NKT-like lymphocytes: Two different T cell subsets that are differentially affected by ageing, Exp Gerontol, 42, 703, 10.1016/j.exger.2007.05.002 Lin, 2006, Comparative gene expression analysis of NKT cell subpopulations, J Leukoc Biol, 80, 164, 10.1189/jlb.0705421 O’Reilly, 2011, Distinct and overlapping effector functions of expanded human CD4+. CD8α+ and CD4–CD8α– invariant natural killer T cells, PLoS One, 6, e28648, 10.1371/journal.pone.0028648 Takahashi, 2002, Cutting edge: Analysis of human V alpha 24+CD8+ NK T cells activated by alpha-galactosylceramide-pulsed monocyte-derived dendritic cells, J Immunol, 168, 3140, 10.4049/jimmunol.168.7.3140 Miyamoto, 2001, A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells, Nature, 413, 531, 10.1038/35097097 Lee Pt, 2002, Distinct functional lineages of human V(alpha)24 natural killer T cells, J Exp Med, 195, 637, 10.1084/jem.20011908 Exley, 1998, CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24J alpha Q T cell receptor alpha chains, J Exp Med, 188, 867, 10.1084/jem.188.5.867 Ho, 2004, CD4(–)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion, J Immunol, 172, 7350, 10.4049/jimmunol.172.12.7350 Cho, 2011, Numerical and functional deficiencies of natural killer T cells in systemic lupus erythematosus: their deficiency related to disease activity, Rheumatology (Oxford), 50, 1054, 10.1093/rheumatology/keq457 Parietti, 2010, Rituximab treatment overcomes reduction of regulatory iNKT cells in patients with rheumatoid arthritis, Clin Immunol, 134, 331, 10.1016/j.clim.2009.11.007 Roman-Gonzalez, 2009, Frequency and function of circulating invariant NKT cells in autoimmune diabetes mellitus and thyroid diseases in Colombian patients, Hum Immunol, 70, 262, 10.1016/j.humimm.2009.01.012 Kee, 2012, Dysfunction of natural killer T cells in patients with active mycobacterium tuberculosis infection, Infect Immun, 80, 2100, 10.1128/IAI.06018-11 Mureithi, 2011, Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection, AIDS Res Hum Retrov, 27, 501, 10.1089/aid.2010.0237 Jiang, 2011, Restored circulating invariant NKT cells are associated with viral control in patients with chronic hepatitis B, PLoS One, 6, e28871, 10.1371/journal.pone.0028871 Veldt, 2007, Randomized placebo controlled phase i/ii trial of a-galactosylceramide for the treatment of chronic hepatitis C, J Hepatol, 47, 356, 10.1016/j.jhep.2007.04.018 O’Konek, 2012, The role of NKT cells in the immune regulation of neoplastic disease, 7 Hunn, 2013, Exploiting invariant NKT cells to promote T-cell responses to cancer vaccines, Oncoimmunology, 2, e23789, 10.4161/onci.23789 Woltman, 2009, α-Galactosylceramide in chronic hepatitis B infection: Results from a randomized placebo-controlled Phase I/II trial, Antivir Ther, 14, 809, 10.3851/IMP1295 Giaccone, 2002, A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors, Clin Cancer Res, 8, 3702 Nieda, 2004, Therapeutic activation of Valpha24+Vbeta11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity, Blood, 103, 383, 10.1182/blood-2003-04-1155 Richter, 2013, Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma, Blood, 121, 423, 10.1182/blood-2012-06-435503 Ishikawa, 2005, A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer, Clin Cancer Res, 11, 1910, 10.1158/1078-0432.CCR-04-1453 Motohashi, 2009, A phase I-II study of alpha-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer, J Immunol, 182, 2492, 10.4049/jimmunol.0800126