Limonoids and tricyclic diterpenoids from Azadirachta indica and their antitumor activities

Kitdamrongtham, 2014, Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities, Chem. Biodivers., 11, 73, 10.1002/cbdv.201300266 Singh, 2002, Comparison of AFLP and SAMPL markers for assessment of intra-population genetic variation in Azadirachta indica A. Juss, Plant Sci., 162, 17, 10.1016/S0168-9452(01)00503-9 Pandey, 2014, Evaluation of phytochemical, antibacterial and free radical scavenging properties of Azadirachta indica (Neem) leaves, Int. J. Pharm. Pharmaceut. Sci., 6, 444 Subapriya, 2005, Medicinal properties of neem leaves: a review, Curr. Med. Chem. Anticancer Agents, 5, 146, 10.2174/1568011053174828 Clayton, 1996, Med. Plants Thailand, 1 Gunadharini, 2011, Induction of apoptosis and inhibition of PI3K/Akt pathway in PC-3 and LNCaP prostate cancer cells by ethanolic neem leaf extract, J. Ethnopharmaco., 134, 644, 10.1016/j.jep.2011.01.015 Kumar, 2006, Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3), J. Ethnopharmaco., 105, 246, 10.1016/j.jep.2005.11.006 Wu, 2014, Preclinical evaluation of the supercritical extract of Azadirachta indica (Neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth, Mol. Cancer Ther., 13, 1067, 10.1158/1535-7163.MCT-13-0699 Anyaehie, 2009, Medicinal properties of fractionated acetone/water neem [Azadirachta indica] leaf extract from Nigeria: a review, Niger J. Physiol. Sci., 24, 157 Yin, 2005, Isolation and structure identification of the compounds from the seeds and leaves of Azadirachta indica A. Juss, J. China Pharm. Uni., 36, 10 Takagi, 2014, Cytotoxic and melanogenesis-inhibitory activities of limonoids from the leaves of Azadirachta indica (Neem), Chem. Biodivers., 11, 451, 10.1002/cbdv.201300348 Chen, 2018, Limonoids fromseeds of Azadirachta indica A. Juss. and their cytotoxic activity, Acta Pharm. Sin. B., 8, 639, 10.1016/j.apsb.2017.12.009 Priyadarsini, 2010, The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells, Free Radic Res., 44, 624, 10.3109/10715761003692503 Han, 2015, Limonoids and Triterpenoids from Dysoxylum mollissimum var. glaberrimum, J. Nat. Prod., 78, 754, 10.1021/np500967k G. Gopalakrishnan, N.D. Pradeep Singh, V. Kasinath, M. Siva Rama Krishnan, R. Malathi, S.S. Rajan, Microwave- and ultrasound-assisted oxidation of bio-active limonoids, Tetrahedron Lett. 42 (2001) 6577–6579. Akihisa, 2011, The melanogenesis-inhibitory, anti-inflammatory, and chemopreventive effects of limonoids in n-hexane extract of Azadirachta indica A. Juss. (Neem) seeds, J. Oleo Sci., 60, 53, 10.5650/jos.60.53 Manosroi, 2014, Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities, Chem. Biodivers., 11, 505, 10.1002/cbdv.201300406 Rojatkar, 1998, Photo-oxidation of nimbin a tetranortriterpenoid from Azadirachta indica (A. Juss), Nat. Prod. Lett., 11, 181, 10.1080/10575639808044944 Nakano, 1998, J. Chem. Soc. Perkin Trans., 1, 1423, 10.1039/a708795k Ara, 1989, Diterpenoids from the stem bark of Azadirachta indica, Phytochemistry, 28, 1177, 10.1016/0031-9422(89)80204-3 Ara, 1988, Tricyclic diterpenoids from the stem bark of Azadirachta indica, J. Nat. Prod., 51, 1054, 10.1021/np50060a002 Ara, 1988, Terpenoids from the stem bark of Azadirachta indica, Phytochemistry, 27, 1801, 10.1016/0031-9422(88)80447-3 Ara, 1990, Tricyclic diterpenoids from root bark of Azadzrachta indica, Phytochemistry, 29, 911, 10.1016/0031-9422(90)80044-H Siddiqui, 1988, Phenolic tricyclic diterpenoids from the bark of Azadirachta indica, Phytochemistry, 27, 3903, 10.1016/0031-9422(88)83041-3 Martin, 1995, Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl, J. Exp. Med., 182, 1545, 10.1084/jem.182.5.1545 Salvesen, 1997, Caspases: intracellular signaling by proteolysis, Cell, 91, 443, 10.1016/S0092-8674(00)80430-4 Thornberry, 1998, Caspases: enemies within, Science, 281, 1312, 10.1126/science.281.5381.1312 Kluck, 1999, The pro-apoptotic proteins, bid and bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol, J. Cell. Biol., 147, 809, 10.1083/jcb.147.4.809 Luo, 1998, Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors, Cell, 94, 481, 10.1016/S0092-8674(00)81589-5