Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Tài liệu tham khảo
Andersson, 2002, Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay, Am. J. Med. Genet., 113, 315, 10.1002/ajmg.b.10873
Ascenzi, 2006, Structure-function relationship of estrogen receptor alpha and beta: impact on human health, Mol. Aspects Med., 27, 299, 10.1016/j.mam.2006.07.001
Ayers, 2007, Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARgamma by FABP4, Biochemistry, 46, 6744, 10.1021/bi700047a
Bookout, 2006, Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network, Cell, 126, 789, 10.1016/j.cell.2006.06.049
Brown, 1997, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5
Chakravarthy, 2009, Identification of a physiologically relevant endogenous ligand for PPARalpha in liver, Cell, 138, 476, 10.1016/j.cell.2009.05.036
Cuzick, 2011, Preventive therapy for breast cancer: a consensus statement, Lancet Oncol., 12, 496, 10.1016/S1470-2045(11)70030-4
Duellman, 2010, A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha), Biochem. Pharmacol., 80, 819, 10.1016/j.bcp.2010.05.024
Echaniz-Laguna, 2010, Neuromuscular symptoms and elevated creatine kinase after statin withdrawal, N. Engl. J. Med., 362, 564, 10.1056/NEJMc0908215
Eskiocak, 2014, The estrogen-related receptor α inverse agonist XCT 790 is a nanomolar mitochondrial uncoupler, Biochemistry, 53, 4839, 10.1021/bi500737n
FitzPatrick, 1998, Clinical phenotype of desmosterolosis, Am. J. Med. Genet., 75, 145, 10.1002/(SICI)1096-8628(19980113)75:2<145::AID-AJMG5>3.0.CO;2-S
Flück, 2004, Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome, Nat. Genet., 36, 228, 10.1038/ng1300
Gallet, 2010, ERR receptors as potential targets in osteoporosis, Trends Endocrinol. Metab., 21, 637, 10.1016/j.tem.2010.06.008
Giguère, 2002, To ERR in the estrogen pathway, Trends Endocrinol. Metab., 13, 220, 10.1016/S1043-2760(02)00592-1
Giguère, 2008, Transcriptional control of energy homeostasis by the estrogen-related receptors, Endocr. Rev., 29, 677, 10.1210/er.2008-0017
Giguère, 1988, Identification of a new class of steroid hormone receptors, Nature, 331, 91, 10.1038/331091a0
Greschik, 2008, Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop, J. Biol. Chem., 283, 20220, 10.1074/jbc.M801920200
Hanai, 2007, The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity, J. Clin. Invest., 117, 3940
Horard, 2003, Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand, J. Mol. Endocrinol., 31, 349, 10.1677/jme.0.0310349
Huss, 2004, Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle, Mol. Cell. Biol., 24, 9079, 10.1128/MCB.24.20.9079-9091.2004
Johnston, 2003, Aromatase inhibitors for breast cancer: lessons from the laboratory, Nat. Rev. Cancer, 3, 821, 10.1038/nrc1211
Kallen, 2004, Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha, J. Biol. Chem., 279, 49330, 10.1074/jbc.M407999200
Kim, 2011, A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands, Mol. Biosyst., 7, 1046, 10.1039/c0mb00324g
Kong, 1999, OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis, Nature, 397, 315, 10.1038/16852
Kumar, 2008, Estrogen receptor-negative breast cancer is less likely to arise among lipophilic statin users, Cancer Epidemiol. Biomarkers Prev., 17, 1028, 10.1158/1055-9965.EPI-07-0726
Luo, 2003, Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha, Mol. Cell. Biol., 23, 7947, 10.1128/MCB.23.22.7947-7956.2003
McDonald, 2007, Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry, Methods Enzymol., 432, 145, 10.1016/S0076-6879(07)32006-5
Novack, 2008, The osteoclast: friend or foe?, Annu. Rev. Pathol., 3, 457, 10.1146/annurev.pathmechdis.3.121806.151431
Orozco, 2004, Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women, Eur. J. Epidemiol., 19, 1105, 10.1007/s10654-004-1706-8
Patch, 2011, Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents, J. Med. Chem., 54, 788, 10.1021/jm101063h
Russell, 2011, Bisphosphonates: the first 40 years, Bone, 49, 2, 10.1016/j.bone.2011.04.022
Sathasivam, 2012, Statin induced myotoxicity, Eur. J. Intern. Med., 23, 317, 10.1016/j.ejim.2012.01.004
Schaaf, 2011, Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature, Am. J. Med. Genet. A., 155A, 1597, 10.1002/ajmg.a.34040
Sladek, 1997, The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene, Mol. Cell. Biol., 17, 5400, 10.1128/MCB.17.9.5400
Smith, 2006, XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification, Anal. Chem., 78, 779, 10.1021/ac051437y
Spann, 2012, Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses, Cell, 151, 138, 10.1016/j.cell.2012.06.054
Stein, 2006, Estrogen-related receptor alpha as a therapeutic target in cancer, Endocr. Relat. Cancer, 13, S25, 10.1677/erc.1.01292
Suzuki, 2004, Estrogen-related receptor alpha in human breast carcinoma as a potent prognostic factor, Cancer Res., 64, 4670, 10.1158/0008-5472.CAN-04-0250
Tagore, 2008, A global metabolite profiling approach to identify protein-metabolite interactions, J. Am. Chem. Soc., 130, 14111, 10.1021/ja806463c
Tarakida, 2011, Hypercholesterolemia accelerates bone loss in postmenopausal women, Climacteric, 14, 105, 10.3109/13697137.2010.507888
Toledano, 2000, Statins: not just for cholesterol?, Trends Endocrinol. Metab., 11, 255, 10.1016/S1043-2760(00)00295-2
Tomaszewski, 2011, Statin-induced myopathies, Pharmacological Rep., 63, 859, 10.1016/S1734-1140(11)70601-6
Tremblay, 2001, Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta, Genes Dev., 15, 833, 10.1101/gad.873401
Trott, 2010, AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem., 31, 455
Vinayavekhin, 2011, Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach, J. Am. Chem. Soc., 133, 17168, 10.1021/ja208199h
Walsh, 2012, Heart drugs that affect bone, Trends Endocrinol. Metab., 23, 163, 10.1016/j.tem.2011.10.002
Wan, 2010, PPARgamma in bone homeostasis. Trends in endocrinology and metabolism, Trends Endocrinol. Metab., 21, 722, 10.1016/j.tem.2010.08.006
Wei, 2010, PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss, Cell Metab., 11, 503, 10.1016/j.cmet.2010.04.015
Wei, 2011, Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin, Mol. Cell. Biol., 31, 4706, 10.1128/MCB.05980-11
Wu, 2009, Estrogen-related receptor alpha (ERRalpha) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells, Chem. Biol. Interact., 181, 236, 10.1016/j.cbi.2009.05.008
Xing, 2013, Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis, J. Bone Miner. Res., 28, 1962, 10.1002/jbmr.1935
