Lifestyle Variables, Non‐traditional Cardiovascular Risk Factors, and the Metabolic Syndrome in an Aboriginal Canadian Population

Obesity - Tập 14 Số 3 - Trang 500-508 - 2006
Juan Liu1, T. Kue Young1, Bernard Zinman2,3, Stewart B. Harris4, Philip W. Connelly2,5, Anthony J. Hanley2,6,1,3
1Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
2Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
3Leadership Sinai Centre for Diabetes, Mt. Sinai Hospital, Toronto, Ontario, Canada
4Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada
5J. Alick Little Lipid Research Laboratory, Toronto, Ontario, Canada.
6Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada

Tóm tắt

AbstractObjective: To examine lifestyle factors associated with metabolic syndrome (MetS) and to explore the relationships between MetS and non‐traditional cardiovascular disease risk factors [adiponectin, leptin, C‐reactive protein (CRP), interleukin‐6 (IL‐6), and serum amyloid A (SAA)] in an isolated Aboriginal Canadian community.Research Methods and Procedures: Data were obtained from 360 non‐diabetic adults participating in a population‐based study of Aboriginal Canadians. Fasting samples were drawn for glucose, insulin, lipids, adiponectin, leptin, CRP, IL‐6, and SAA. Percentage body fat was measured using bioelectrical impedance analysis. Past year physical activity and fitness level were assessed. MetS was diagnosed according to the criteria of the National Cholesterol Education Program, the World Health Organization, and the International Diabetes Federation.Results: The results showed that older age, higher percentage body fat, and lower fitness levels were associated with increased odds of MetS regardless of MetS definition and subject gender. Past year physical activity was independently related with the World Health Organization‐MetS in male subjects. Subjects with MetS had significantly higher leptin, CRP, IL‐6, and SAA levels and lower adiponectin levels; however, only adiponectin remained significantly low after adjustment for age and percentage body fat.Discussion: The study showed that higher percentage body fat and lower physical activity and fitness were associated with a higher prevalence of MetS in this Aboriginal community and that hypoadiponectinemia was independently associated with MetS.

Từ khóa


Tài liệu tham khảo

10.2337/diacare.27.11.2689

10.2337/diacare.24.4.683

10.1503/cmaj.1040834

10.1161/01.CIR.0000080897.52664.94

10.2337/diacare.26.3.861

10.2337/diacare.26.11.3153

10.2337/diab.37.12.1595

10.2337/diacare.14.3.173

10.1093/oxfordjournals.epirev.a017978

10.1093/aje/152.10.908

National Cholesterol Education Program, 2001, Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, and treatment of high blood cholesterol in adults (Adult Treatment Panel III), JAMA, 285, 2486, 10.1001/jama.285.19.2486

10.2337/diacare.21.10.1637

10.2337/diacare.27.2.538

10.1038/oby.2002.126

10.2337/diacare.25.9.1612

10.1016/j.metabol.2004.04.017

10.1093/ije/dyg179

10.1210/jcem.86.5.7463

10.1210/jcem.87.6.8550

10.1016/S0140-6736(02)09335-2

10.1136/bmj.313.7063.965

10.1161/01.ATV.18.6.928

10.1007/s001250050822

10.1161/01.CIR.102.1.42

10.2337/diacare.23.12.1835

10.1016/S0021-9150(03)00134-5

10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S

International Diabetes Federation, The IDF Consensus Worldwide Definition of the Metabolic Syndrome: 2005

10.1016/j.ecl.2004.03.005

10.2337/diacare.24.10.1787

10.1093/jn/128.3.541

10.1161/01.CIR.0000080884.27358.49

10.2337/diacare.28.9.2289

Hanley A. J., 1995, The Sandy Lake Health and Diabetes Project: design, methods and lessons learned, Chronic Dis Canada, 16, 149

10.2337/diacare.20.2.185

10.2337/diacare.20.9.1408

10.1038/sj.ijo.0802239

10.2337/diacare.26.12.3219

10.1097/00005768-199706001-00003

10.1093/oxfordjournals.aje.a114010

10.1007/BF00280883

10.1001/jama.279.9.669

10.1249/01.MSS.0000089337.73244.9B

10.1056/NEJMoa012512

10.1016/j.ecl.2004.03.008

10.1007/s00125-004-1472-x

10.1161/01.ATV.0000073313.16135.21

10.1016/j.jpeds.2004.11.033

10.1161/01.ATV.0000099786.99623.EF

10.1097/00041433-200312000-00003

10.1210/jc.2004-2427

10.1038/sj.ijo.0802983

Thông tin
Thông tin xuất bản

Obesity

Tập 14 Số 3

500-508

Thông tin tác giả