Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation

Assari, 2018, Blacks' diminished health return of family structure and socioeconomic status; 15 years of follow-up of a national urban sample of youth, J Urban Health, 95, 21, 10.1007/s11524-017-0217-3 Beaudart, 2017, Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review, Osteoporos Int., 28, 1817, 10.1007/s00198-017-3980-9 Bohannon, 2008, Hand-grip dynamometry predicts future outcomes in aging adults, J. Geriatr. Phys. Ther., 31, 3, 10.1519/00139143-200831010-00002 Brown, 2019, Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training, Exp. Gerontol., 125, 110657, 10.1016/j.exger.2019.110657 Casanova, 2011, The 6-min walk distance in healthy subjects: reference standards from seven countries, Eur. Respir. J., 37, 150, 10.1183/09031936.00194909 Collins, 2016, A high-fat high-sucrose diet rapidly alters muscle integrity, inflammation and gut microbiota in male rats, Sci. Rep., 11, 37278, 10.1038/srep37278 Doherty, 2003, Invited review: aging and sarcopenia, J. Appl. Physiol. (1985), 95, 1717, 10.1152/japplphysiol.00347.2003 Durrant, 2009, Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase, J Physiol., 587, 3271, 10.1113/jphysiol.2009.169771 Evans, 1993, Sarcopenia and age-related changes in body composition and functional capacity, J. Nutr., 123, 465, 10.1093/jn/123.suppl_2.465 Ferrucci, 2018, Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty, Nat Rev Cardiol., 15, 505, 10.1038/s41569-018-0064-2 FIFoA-R S. Older Americans 2008: key indicators of wellbeing. U.W. Government Printing Office, Washington. Fleenor, 2010, Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise, J. Physiol., 588, 3971, 10.1113/jphysiol.2010.194753 Fried, 1997, Disability in older adults: evidence regarding significance, etiology, and risk, J. Am. Geriatr. Soc., 45, 92, 10.1111/j.1532-5415.1997.tb00986.x Fried, 2001, Frailty in older adults: evidence for a phenotype, J. Gerontol. A Biol. Sci. Med. Sci., 56, M146, 10.1093/gerona/56.3.M146 Fries, 1980, Aging, natural death, and the compression of morbidity, N. Engl. J. Med., 303, 130, 10.1056/NEJM198007173030304 Gioscia-Ryan, 2021, Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice, J Physiol., 599, 911, 10.1113/JP280607 Gioscia-Ryan, 2021, Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening, Geroscience, 43, 423, 10.1007/s11357-020-00212-1 Guralnik, 1995, Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability, N Engl J Med., 332, 556, 10.1056/NEJM199503023320902 Hagan, 2017 Hambright, 2019, Murine models of accelerated aging and musculoskeletal disease, Bone, 08, 122, 10.1016/j.bone.2019.03.002 Hatori, 2012, Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet, Cell Metab., 15, 848, 10.1016/j.cmet.2012.04.019 Hintze, 2018, Modeling the western diet for preclinical investigations, Adv Nutr., 9, 263, 10.1093/advances/nmy002 Inzitari, 2011, Nutrition in the age-related disablement process, J. Nutr. Health Aging., 15, 599, 10.1007/s12603-011-0053-1 Justice, 2014, Battery of behavioral tests in mice that models age-associated changes in human motor function, Age (Dordr)., 36, 583, 10.1007/s11357-013-9589-9 Justice, 2015, Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice, J. Appl. Physiol. (1985), 118, 163, 10.1152/japplphysiol.00608.2014 Kirkland, 2013, Translating advances from the basic biology of aging into clinical application, Exp. Gerontol., 48, 1, 10.1016/j.exger.2012.11.014 Kirkland, 2009, Healthspan, translation, and new outcomes for animal studies of aging, J Gerontol A Biol Sci Med Sci., 64, 209, 10.1093/gerona/gln063 Landi, 2018, Impact of habitual physical activity and type of exercise on physical performance across ages in community-living people, PLoS One, 13, 10.1371/journal.pone.0191820 Lee, 2015, Effects of chronic high-fat feeding on skeletal muscle mass and function in middle-aged mice, Aging Clin. Exp. Res., 27, 403, 10.1007/s40520-015-0316-5 León-Muñoz, 2015, Major dietary patterns and risk of frailty in older adults: a prospective cohort study, BMC Med., 13, 11, 10.1186/s12916-014-0255-6 Lesniewski, 2013, Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise, Exp Gerontol., 48, 1218, 10.1016/j.exger.2013.08.001 Levin, 2017, The beneficial effects of different types of exercise interventions on motor and cognitive functions in older age: a systematic review, Eur. Rev. Aging Phys. Act., 14, 20, 10.1186/s11556-017-0189-z Olshansky, 2009, Aging in America in the twenty-first century: demographic forecasts from the MacArthur Foundation Research Network on an Aging Society, Milbank Q., 87, 842, 10.1111/j.1468-0009.2009.00581.x Pérez-Schindler, 2017, Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle, Sci Rep., 7, 13485, 10.1038/s41598-017-14081-w Pontzer, 2021, Daily energy expenditure through the human life course, Science, 373, 808, 10.1126/science.abe5017 Rantanen, 1999, Midlife hand grip strength as a predictor of old age disability, JAMA, 281, 558, 10.1001/jama.281.6.558 Rantanen, 2012, Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort, Age (Dordr), 34, 563, 10.1007/s11357-011-9256-y Rivera-Torres, 2019, Adherence to exercise programs in older adults: informative report, Gerontol. Geriatr. Med., 5, 10.1177/2333721418823604 Samorajski, 1985, Effect of exercise on longevity, body weight, locomotor performance, and passive-avoidance memory of C57BL/6J mice, Neurobiol. Aging, 6, 17, 10.1016/0197-4580(85)90066-1 Schoenborn, 2011, Adherence to the 2008 adult physical activity guidelines and mortality risk, Am. J. Prev. Med., 40, 514, 10.1016/j.amepre.2010.12.029 Shabani, 2020, Resveratrol alleviates obesity-induced skeletal muscle inflammation via decreasing M1 macrophage polarization and increasing the regulatory T cell population, Sci. Rep., 10, 3791, 10.1038/s41598-020-60185-1 Tam, 2015, The effects of high-fat feeding on physical function and skeletal muscle extracellular matrix, Nutr. Diabetes, 5, 10.1038/nutd.2015.39 2016, ILAR J., 57 Thompson, 2009, Age-related muscle dysfunction, Exp. Gerontol., 44, 106, 10.1016/j.exger.2008.05.003 Troiano, 2008, Physical activity in the United States measured by accelerometer, Med. Sci. Sports Exerc., 40, 181, 10.1249/mss.0b013e31815a51b3 Veniaminova, 2020, Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice, Life Sci., 241, 10.1016/j.lfs.2019.117163 Volpi, 2004, Muscle tissue changes with aging, Curr. Opin. Clin. Nutr. Metab. Care, 7, 405, 10.1097/01.mco.0000134362.76653.b2 Woollacott, 1986, Aging and posture control: changes in sensory organization and muscular coordination, Int. J. Aging Hum. Dev., 23, 97, 10.2190/VXN3-N3RT-54JB-X16X