Libman-Sacks endocarditis in the antiphospholipid syndrome: immunopathologic findings in deformed heart valves

Lupus - Tập 5 Số 3 - Trang 196-205 - 1996
Lea Ziporen1, Iris Goldberg2, Michael Arad3, Maja Hojnik1, Josep Ordi‐Ros4, A Afek2, Miri Blank1, Y. Sandbank3, M. Vilardell-Tarrés4, Inés de Torres4, Abraham Weinberger3, Asherson Ra5, Y. Kopolovic2, Søren Jacobsen1
1Research Unit of Autoimmune Diseases and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel
2Department of Pathology, Sheba Medical Center, Tel-Hashomer, Israel
3Departments of Internal Medicine and Pathology, Beilinson Hospital, Petach Tikva
4internal Medicine 3° Planta, Vall D'Hebron, Barcelona, Spain
5Rheumatic Diseases Unit, Department of Medicine, University of Capetown, School of Medicine, Capetown, South Africa

Tóm tắt

Objective. To examine the potential immunologic mechanism and involvement of antiphos pholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphos pholipid syndrome (APS).

Methods. Immunoperoxidase and immunofluorescence staining methods were used to evaluate 13 heart valve specimens derived from eight patients with the APS, either primary or secondary to systemic lupus erythematosus. Primary antibodies to human immuno globulins, complement components, serum albumin and a monoclonal anti-idiotypic anti body to human anticardiolipin antibodies (aCL) were employed. Various tissue specimens from a patient with the APS as well as deformed and normal valves from subjects without the APS were used as controls.

Results. Linear subendothelial deposition consisting of immunoglobulins with complement components but not of a non-specific serum protein was found in deformed valves from patients with the APS. None of the control valves or tissues disclosed similar deposition. The same pattern and location of staining was obtained by the anti-idiotypic antibody to aCL. A significant amount of IgG immunoglobulins that bound to cardiolipin was eluted from a valve of a patient with secondary APS.

Conclusion. Deposits of immunoglobulins including aCL, and of complement components, are common in affected valves of patients with primary and secondary APS. Such deposits may be involved in the pathogenesis of valvular lesions.

Từ khóa


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Lupus

Tập 5 Số 3

196-205

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