Levels of vitamin D and cardiometabolic disorders: Systematic review and meta-analysis

Despres, 2008, From individual risk factors and the metabolic syndrome to global cardiometabolic risk, Eur Heart J Suppl, 10, B24, 10.1093/eurheartj/sum041

Grundy, 2008, A changing paradigm for prevention of cardiovascular disease: emergence of the metabolic syndrome as a multiplex risk factor, Eur Heart J Suppl, 10, B16, 10.1093/eurheartj/sum044

Fisher, 2006, Cardiometabolic disease: the new challenge?, Pract Diabetes Int, 23, 95, 10.1002/pdi.909

Lee, 2008, Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?, J Am Coll Cardiol, 52, 1949, 10.1016/j.jacc.2008.08.050

Tangpricha, 2002, Vitamin D insufficiency among free-living healthy young adults, Am J Med, 112, 659, 10.1016/S0002-9343(02)01091-4

Holick, 1989, Age, vitamin-D and solar ultraviolet light, Lancet, 2, 1104, 10.1016/S0140-6736(89)91124-0

Maclaughlin, 1985, Aging decreases the capacity of human-skin to produce vitmamin-D3, J Clin Invest, 76, 1536, 10.1172/JCI112134

McCullough, 2009, Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer, Annu Rev Nutr, 29, 111, 10.1146/annurev-nutr-080508-141248

Pittas, 2007, Review: The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis, J Clin Endocrinol Metab, 92, 2017, 10.1210/jc.2007-0298

Cantorna, 2004, Vitamin D status, 1,25-dihydroxyvitamin D-3, and the immune system, Am J Clin Nutr, 80, 1717S, 10.1093/ajcn/80.6.1717S

Tangpricha, 2001, 25-Hydroxyvitamin D-1 alpha-hydroxylase in normal and malignant colon tissue, Lancet, 357, 1673, 10.1016/S0140-6736(00)04831-5

Palomer, 2008, Role of vitamin D in the pathogenesis of type 2 diabetes mellitus, Diabetes Obes Metab, 10, 185, 10.1111/j.1463-1326.2007.00710.x

Wallis, 2008, The “sunshine deficit” and cardiovascular disease, Circulation, 118, 1476, 10.1161/CIRCULATIONAHA.107.713339

Lu, 2009, Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals, Diabetes Care, 32, 1278, 10.2337/dc09-0209

Holick, 2007, Vitamin D deficiency, N Engl J Med, 357, 266, 10.1056/NEJMra070553

Mantel, 1959, Statistical aspects of the analysis of data from retrospective studies of disease, J Natl Cancer Inst, 22, 719

Higgins, 2004, Controlling the risk of spurious findings from meta-regression, Stat Med, 23, 1663, 10.1002/sim.1752

Egger, 1998, Bias in meta-analysis detected by a simple, graphical test—reply, Br Med J, 316, 470

Rosenberg, 1976, Vitamin-responsive inherited metabolic disorders, Adv Hum Genet, 6, 1

Taussig, 1966, Possible injury to the cardiovascular system from vitamin D, Ann Intern Med, 65, 1195, 10.7326/0003-4819-65-6-1195

Zittermann, 2003, Low vitamin D status and inadequate calcium intake—risk factors for the metabolic syndrome?, Ernahrungs-Umschau, 50, 84

Beuren, 1966, Vitamin-D-hypercalcamische herz- und gefasserkrankung, Deut Med Wochenschr, 91, 881, 10.1055/s-0028-1110669

Beuren, 1966, Vitamin D-hypercalcemia cardiovascular disease, Dtsch Med Wochenschr, 91, 881, 10.1055/s-0028-1110669

Al-Delaimy, 2003, A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men, Am J Clin Nutr, 77, 814, 10.1093/ajcn/77.4.814

Bid, 2009, Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus: a North Indian study, Indian J Med Sci, 63, 187

Bouillon, 2006, Vitamin D resistance, Best Pract Res Clin Endocrinol Metab, 20, 627, 10.1016/j.beem.2006.09.008

Mehrotra, 2009, Chronic kidney disease, hypovitaminosis D, and mortality in the United States, Kidney Int

Schmidt-Gayk, 1977, Serum 25-hydroxycalciferol in myocardial infarction, Atherosclerosis, 26, 55, 10.1016/0021-9150(77)90139-3

Suzuki, 2006, Hypovitaminosis D in type 2 diabetes mellitus: association with microvascular complications and type of treatment, Endocr J, 53, 503, 10.1507/endocrj.K06-001

Reis, 2009, Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis, Atherosclerosis

Targher, 2006, Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients, Clin Endocrinol (Oxf), 65, 593, 10.1111/j.1365-2265.2006.02633.x

Arroyo, 2006, Micronutrients in African-Americans with decompensated and compensated heart failure, Transl Res, 148, 301, 10.1016/j.trsl.2006.08.003

Auwerx, 1988, Mineral metabolism and bone mass at peripheral and axial skeleton in diabetes mellitus, Diabetes, 37, 8, 10.2337/diabetes.37.1.8

Baynes, 1997, Vitamin D, glucose tolerance and insulinaemia in elderly men, Diabetologia, 40, 344, 10.1007/s001250050685

Blasiak, 1989, Serum levels of calcitonin, parathyroid hormone and 25-hydroxycholecalciferol in patients with diabetes mellitus, Endokrynol Pol, 40, 241

Dobnig, 2008, Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality, Arch Intern Med, 168, 1340, 10.1001/archinte.168.12.1340

Fisher, 2007, Relationships between myocardial injury, all-cause mortality, vitamin D, PTH, and biochemical bone turnover markers in older patients with hip fractures, Ann Clin Lab Sci, 37, 222

Fahrleitner-Pammer, 2008, Bone markers predict cardiovascular events in chronic kidney disease, J Bone Miner Res, 23, 1850, 10.1359/jbmr.080610

Boucher, 1995, Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians, Diabetologia, 38, 1239, 10.1007/BF00422375

Garakyaraghi, 2009, Calcium and vitamin D status in heart failure patients in Isfahan, Iran, Biol Trace Elem Res

Boxer, 2008, The association between vitamin D and inflammation with the 6-minute walk and frailty in patients with heart failure, J Am Geriatr Soc, 56, 454, 10.1111/j.1532-5415.2007.01601.x

Chen, 2008, Hypovitaminosis D and parathyroid hormone response in the elderly: effects on bone turnover and mortality, Clin Endocrinol, 68, 290, 10.1111/j.1365-2265.2007.03040.x

Zittermann, 2009, Circulating calcitriol concentrations and total mortality, Clin Chem, 55, 1163, 10.1373/clinchem.2008.120006

Bostick, 1999, Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women, Am J Epidemiol, 149, 151, 10.1093/oxfordjournals.aje.a009781

Weishaar, 1987, Involvement of vitamin D3 with cardiovascular function. II. Direct and indirect effects, Am J Physiol, 253, E675

Lund, 1978, Vitamin D and ischaemic heart disease, Horm Metab Res, 10, 553, 10.1055/s-0028-1093390

Merzon, 1988, Plasma 25-hydroxyvitamin D3 level in patients with chronic cardiac insufficiency, Kardiologiia, 28, 108

Martins, 2008, Association of low vitamin D levels with metabolic syndrome, Ethnicity Dis, 18, 032

Melamed, 2009, Vitamin D: does it reduce risk of cardiovascular disease and all-cause mortality?, Am J Epidemiol, 169, S87

Momiyama, 2002, Ssociations of plasma vitamin D and osteopotin levels with coronary artery calcification, J Am Coll Cardiol, 39, 266A, 10.1016/S0735-1097(02)81192-5

Munger, 1991, Vitamin D and calcium intake and subsequent risk of stroke in a cohort of Iowa women, Circulation, 83

Pilz, 2009, Vitamin D deficiency is associated with type 2 diabetes mellitus and insulin resistance in 3290 patients referred to coronary angiography, Diabetologia, 52, 309

Pittas, 2005, A prospective study of vitamin D intake and risk of type 2 diabetes in women, Diabetes, 54, A426

Richart, 2008, PTH, vitamin D and their ratio are associated with components of the metabolic syndrome in the general population, J Hypertens, 26, S119

Schneider, 1976, Diabetes and vitamin-D metabolism, Clin Res, 24, A567

Seelig, 1975, Ischaemic heart-disease, vitamin-D, vitamin-A and magnesium, Br Med J, 3, 647, 10.1136/bmj.3.5984.647-d

Szep, 2008, Association of serum vitamin D levels and type 2 diabetes in HIV Infection in the Modena cohort, Antiviral Ther, 13, A42

Boucher, 2006, Hypovitaminosis D and risk of Type 2 diabetes in British South Asians, Diabet Med, 23, 336, 10.1111/j.1464-5491.2006.01825a.x

Dalderup, 1973, Ischaemic heart-disease and vitamin D, Lancet, 2, 92, 10.1016/S0140-6736(73)93282-0

Lee, 2009, Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men, Eur J Endocrinol

Birkeland, 2009, Relationship between vitamin D status and insulin secretion and action assessed by the frequently sampled intravenous glucose tolerance test in subjects with the metabolic syndrome, Diabetes, 58, A364

Dobnig, 2007, Serum concentrations of vitamin D are significant and independent predictors of mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, Exp Clin Endocrinol Diabetes, 115, S91, 10.1055/s-2007-972544

Eskin, 1974, Letter: Vitamin D and myocardial infarction, Br Med J, 4, 232, 10.1136/bmj.4.5938.232

Joergensen, 2009, Vitamin D levels and mortality in type 2 diabetes, Diabetologia, 52, 1361

Khalid, 2009, Vitamin D deficiency/resistance and cerebrovascular disease, J Am Geriatr Soc, 57, S185

Laaksonen, 2007, Serum vitamin D and occurrence of subsequent type 2 diabetes: a pooled analysis of two Finnish cohorts, Ann Nutr Metab, 51, 371

Alsafwah, 2008, Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure, Am J Med Sci, 335, 292, 10.1097/MAJ.0b013e318167b0bd

Forouhi, 2008, Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990–2000, Diabetes, 57, 2619, 10.2337/db08-0593

McGill, 2008, Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity, Nutr J, 7, 4, 10.1186/1475-2891-7-4

Poole, 2006, Reduced vitamin D in acute stroke, Stroke, 37, 243, 10.1161/01.STR.0000195184.24297.c1

Pilz, 2008, Low vitamin d levels predict stroke in patients referred to coronary angiography, Stroke, 39, 2611, 10.1161/STROKEAHA.107.513655

Pilz, 2008, Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography, J Clin Endocrinol Metab, 93, 3927, 10.1210/jc.2008-0784

Pilz, 2009, Vitamin D and mortality in older men and women, Clin Endocrinol (Oxf)

Maki, 2009, Serum 25-hydroxyvitamin D is independently associated with high-density lipoprotein cholesterol and the metabolic syndrome in men and women, J Clin Lipidol, 3, 289, 10.1016/j.jacl.2009.07.003

Wang, 2008, Vitamin D deficiency and risk of cardiovascular disease, Circulation, 117, 503, 10.1161/CIRCULATIONAHA.107.706127

Bonakdaran, 2009, Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients, Saudi Med J, 30, 509

Ginde, 2009, Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults, J Am Geriatr Soc

Kilkkinen, 2009, Vitamin D status and the risk of cardiovascular disease death, Am J Epidemiol

Melamed, 2008, 25-Hydroxyvitamin D levels and the risk of mortality in the general population, Arch Intern Med, 168, 1629, 10.1001/archinte.168.15.1629

Melamed, 2008, Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004, Arterioscler Thromb Vasc Biol, 28, 1179, 10.1161/ATVBAHA.108.165886

Reis, 2008, Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial disease, Am J Clin Nutr, 88, 1469, 10.3945/ajcn.2008.26447

Reis, 2008, Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults, Eur J Endocrinol, 159, 41, 10.1530/EJE-08-0072

Chonchol, 2008, Association between 25-hydroxyvitamin D deficiency and cardiovascular disease in type 2 diabetic patients with mild kidney dysfunction, Nephrol Dial Transplant, 23, 269

Giovannucci, 2008, 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study, Arch Intern Med, 168, 1174, 10.1001/archinte.168.11.1174

Kendrick, 2009, 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey, Atherosclerosis, 205, 255, 10.1016/j.atherosclerosis.2008.10.033

Kim, 2008, Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004), Am J Cardiol, 102, 1540, 10.1016/j.amjcard.2008.06.067

Knekt, 2008, Serum vitamin D and subsequent occurrence of type 2 diabetes, Epidemiology, 19, 666, 10.1097/EDE.0b013e318176b8ad

Mattila, 2007, Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes, Diabetes Care, 30, 2569, 10.2337/dc07-0292

Martins, 2007, Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey, Arch Intern Med, 167, 1159, 10.1001/archinte.167.11.1159

Reis, 2007, Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults, Diabetes Care, 30, 1549, 10.2337/dc06-2438

Botella-Carretero, 2007, Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity, Clin Nutr, 26, 573, 10.1016/j.clnu.2007.05.009

Rueda, 2008, Vitamin D, PTH, and the metabolic syndrome in severely obese subjects, Obes Surg, 18, 151, 10.1007/s11695-007-9352-3

Marniemi, 2005, Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects, Nutr Metab Cardiovasc Dis, 15, 188, 10.1016/j.numecd.2005.01.001

Ford, 2005, Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults, Diabetes Care, 28, 1228, 10.2337/diacare.28.5.1228

Cigolini, 2006, Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients, Diabetes Care, 29, 722, 10.2337/diacare.29.03.06.dc05-2148

Scragg, 2004, Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey, Diabetes Care, 27, 2813, 10.2337/diacare.27.12.2813

Rajasree, 2001, Serum 25-hydroxyvitamin D3 levels are elevated in South Indian patients with ischemic heart disease, Eur J Epidemiol, 17, 567, 10.1023/A:1014559600042

Scragg, 1995, Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus, Diabetes Res Clin Pract, 27, 181, 10.1016/0168-8227(95)01040-K

Scragg, 1990, Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study, Int J Epidemiol, 19, 559, 10.1093/ije/19.3.559

Chiu, 2004, Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction, Am J Clin Nutr, 79, 820, 10.1093/ajcn/79.5.820

Hypponen, 2008, 25-Hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort, Diabetes, 57, 298, 10.2337/db07-1122

Pittas, 2007, The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis, J Clin Endocrinol Metab, 92, 2017, 10.1210/jc.2007-0298

Zittermann, 2005, Putting cardiovascular disease and vitamin D insufficiency into perspective, Br J Nutr, 94, 483, 10.1079/BJN20051544

Giovannucci, 2009, Vitamin D and cardiovascular disease, Curr Atheroscler Rep, 11, 456, 10.1007/s11883-009-0068-9

Autier, 2007, Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials, Arch Intern Med, 167, 1730, 10.1001/archinte.167.16.1730