Levels and predictors of airborne and internal exposure to manganese and iron among welders

Journal of Exposure Science and Environmental Epidemiology - Tập 22 Số 3 - Trang 291-298 - 2012
Beate Pesch1, Tobias Weiß2, Benjamin Kendzia1, Jana Henry3, Martin Lehnert1, Anne Lotz1, Evelyn Heinze1, Heiko U. Käfferlein4, Rainer Van Gelder5, Markus Berges6, Jens‐Uwe Hahn7, Markus Mattenklott8, Ewald Punkenburg9, A. Hartwig10, Thomas Brüning11
1Center of Epidemiology, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz, Bochum, Germany
2Department of Human Biomonitoring, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz, Bochum, Germany
3Center of Medicine, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz, Bochum, Germany
4Center of Toxicology, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz, Bochum, Germany
5Division 1, Unit 1.3, Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstrasse, Sankt Augustin, Germany
6Division 3, Unit 3.1, Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstrasse, Sankt Augustin, Germany
7Division 2, Unit 2.1, Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstrasse, Sankt Augustin, Germany
8Division 2, Unit 2.3, Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstrasse, Sankt Augustin, Germany
9BG Holz und Metall, Seligmannallee, Hannover, Germany
10Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Institute of Applied Biosciences, Kaiserstrasse, Karlsruhe, Germany
11Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz, Bochum, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

Martin C.J. Manganese neurotoxicity: connecting the dots along the continuum of dysfunction. Neurotoxicology 2006: 27: 347–349.

Mergler D., Baldwin M., Belanger S., Larribe F., Beuter A., and Bowler R., et al. Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. Neurotoxicology 1999: 20: 327–342.

Couper J. On the effects of black oxide of manganese when inhaled into the lungs. Brit Ann Med Pharm 1837: 1: 41–42.

Aschner M., Lukey B., and Tremblay A. The Manganese Health Research Program (MHRP): status report and future research needs and directions. Neurotoxicology 2005: 27: 733–736.

Bast-Pettersen R., Ellingsen D.G., Hetland S.M., and Thomassen Y. Neuropsychological function in manganese alloy plant workers. Int Arch Occup Environ Health 2004: 77: 277–287.

Lucchini R., Apostoli P., Perrone C., Placidi D., Albini E., and Migliorati P., et al. Long-term exposure to “low levels” of manganese oxides and neurofunctional changes in ferroalloy workers. Neurotoxicology 1999: 20: 287–297.

Myers J.E., teWaterNaude J., Fourie M., Zogoe H.B., Naik I., and Theodorou P., et al. Nervous system effects of occupational manganese exposure on South African manganese mineworkers. Neurotoxicology 2003a: 24: 649–656.

Myers J.E., Thompson M.L., Ramushu S., Young T., Jeebhay M.F., and London L., et al. The nervous system effects of occupational exposure on workers in a South African manganese smelter. Neurotoxicology 2003c: 24: 885–894.

Meyer-Baron M., Knapp G., Schaper M., and van T.C. Performance alterations associated with occupational exposure to manganese--a meta-analysis. Neurotoxicology 2009: 30: 487–496.

Flynn M.R., and Susi P. Manganese, iron, and total particulate exposures to welders. J Occup Environ Hyg 2010: 7: 115–126.

Harris M.K., Ewing W.M., Longo W., DePasquale C., Mount M.D., and Hatfield R., et al. (Manganese exposures during shielded metal arc welding (SMAW) in an enclosed space. J Occup Environ Hyg 2005: 2: 375–382.

Hobson A., Seixas N., Sterling D., and Racette B.A. Estimation of Particulate Mass and Manganese Exposure Levels among Welders. Ann Occup Hyg 2011: 55: 113–125.

ATSDR (Agency for Toxic Substances and Disease Registry). Draft Toxicological Profile for Manganese. US Department of Health and Human Services, Public Health Service, ATSDR, Atlanta, GA, September 2008. www.atsdr.cdc.gov/toxprofiles/tp.asp?id=102&tid=23.

Fitsanakis V.A., Zhang N., Garcia S., and Aschner M. Manganese (Mn) and iron (Fe): interdependency of transport and regulation. Neurotox Res 2010: 18: 124–131.

Kim Y., and Lee B.K. Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008. Neurotoxicology 2011: 32 (2): 247–254.

Meltzer H.M., Brantsaeter A.L., Borch-Iohnsen B., Ellingsen D.G., Alexander J., and Thomassen Y., et al. Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study. Environ Res 2010: 110: 497–504.

Lu L., Zhang L.L., Li G.J., Guo W.R., Liang W.N., and Wei Z. [Altered systemic iron metabolism in welders exposed to manganese]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2006: 24: 31–34.

Gabriel S., Sun Y., and Chen W.H. [On-the-job Insurance League of Germany monitoring system for hazardous substances in working places]. Gefahrstoffe-Reinhaltung der Luft – Air Quality Control 2010: 70: 43–49.

Stamm R. MEGA-database: one million data since 1972. Appl Occup Environ Hyg 2001: 16: 159–163.

Breuer D., Hahn J.U., Hober D., Emmel C., Musanke U., and Ruhl R., et al. Air sampling and determination of vapours and aerosols of bitumen and polycyclic aromatic hydrocarbons in the Human Bitumen Study. Arch Toxicol 2011: 85 (Suppl 1): S11–S20.

Ellingsen D.G., Dubeikovskaya L., Dahl K., Chashchin M., Chashchin V., and Zibarev E., et al. Air exposure assessment and biological monitoring of manganese and other major welding fume components in welders. J Environ Monit 2006: 8: 1078–1086.

Smargiassi A., Baldwin M., Savard S., Kennedy G., Mergler D., and Zayed J. Assessment of exposure to manganese in welding operations during the assembly of heavy excavation machinery accessories. Appl Occup Environ Hyg 2000: 15: 746–750.

Berlinger B., Benker N., Weinbruch S., L’Vov B., Ebert M., and Koch W., et al. Physicochemical characterisation of different welding aerosols. Anal Bioanal Chem 2011: 399: 1773–1780.

McMillan G. Is electric arc welding linked to manganism or Parkinson's disease? Toxicol Rev 2005: 24: 237–257.

Cowan D.M., Fan Q., Zou Y., Shi X., Chen J., and Aschner M., et al. Manganese exposure among smelting workers: blood manganese-iron ratio as a novel tool for manganese exposure assessment. Biomarkers 2009: 14: 3–16.

Myers J.E., Thompson M.L., Naik I., Theodorou P., Esswein E., and Tassell H., et al. The utility of biological monitoring for manganese in ferroalloy smelter workers in South Africa. Neurotoxicology 2003b: 24: 875–883.

Bowler R.M., Roels H.A., Nakagawa S., Drezgic M., Diamond E., and Park R., et al. Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders. Occup Environ Med 2007: 64: 167–177.

Chang Y., Song H.J., Lee J.J., Seo J.H., Kim J.H., and Lee H.J., et al. Neuroplastic changes within the brains of manganese-exposed welders: recruiting additional neural resources for successful motor performance. Occup Environ Med 2010: 67: 809–815.

Bouchard M., Mergler D., Baldwin M., Panisset M., and Roels H.A. Neuropsychiatric symptoms and past manganese exposure in a ferro-alloy plant. Neurotoxicology 2007: 28: 290–297.

Bouchard M., Mergler D., Baldwin M.E., and Panisset M. Manganese cumulative exposure and symptoms: a follow-up study of alloy workers. Neurotoxicology 2008: 29: 577–583.

Ceppi M., Gallo F., and Bonassi S. Study design and statistical analysis of data in human population studies with the micronucleus assay. Mutagenesis 2011: 26: 247–252.

Fowke J.H. Issues in the design of molecular and genetic epidemiologic studies. J Prev Med Public Health 2009: 42: 343–348.

Menke A., Muntner P., Fernandez-Real J.M., and Guallar E. The association of biomarkers of iron status with mortality in US adults. Nutr Metab Cardiovasc Dis 2011; (e-pub ahead of print).

Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., and Boron W.F., et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997: 388: 482–488.

Brain J.D., Heilig E., Donaghey T.C., Knutson M.D., Wessling-Resnick M., and Molina R.M. Effects of iron status on transpulmonary transport and tissue distribution of Mn and Fe. Am J Respir Cell Mol Biol 2006: 34: 330–337.