Levamisole, the story and the lessons

Amery, 1983, The dosage regimen of levamisole in cancer: is it related to efficacy and safety?, Int. J. Immunopharmac., 5, 1, 10.1016/0192-0561(83)90065-6 Amery, 1982, Four-year results from double-blind study of adjuvant levamisole treatment in resectable lung cancer, 123 Amery, 1981, Levamisole and immunotherapy: some theoretic and practical considerations and their relevance to human disease, Oncology, 38, 168, 10.1159/000225546 Amery, 1977, Adjuvant treatment with levamisole in cancer. A review of experimental and clinical data, Cancer Treat. Rev., 4, 167, 10.1016/S0305-7372(77)80023-6 Chirigos, 1973, Augmentation of chemotherapeutically induced remission of a murine leukaemia by a chemical immunoadjuvant, Cancer Rev., 33, 2615 Janssen, 1976, The levamisole story, Vol. 20, 347 Klefstrom, 1985, Levamisole in the treatment of stage II breast cancer, Cancer, 55, 2753, 10.1002/1097-0142(19850615)55:12<2753::AID-CNCR2820551204>3.0.CO;2-Q Lau, 1990, Purification, characterization and structural elucidation of the active moiety of the previously called “Suppressor Activating Factor” (SAF), Cell. Immun., 125, 92, 10.1016/0008-8749(90)90065-Y Laurie, 1989, Surgical adjuvant therapy of large bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil, J. clin. Oncol., 7, 1447, 10.1200/JCO.1989.7.10.1447 Miller, 1980, Use of levamisole in parasitic infections, Drugs, 20, 122, 10.2165/00003495-198020020-00005 Moertel, 1990, Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma, New Engl. J. Med., 322, 352, 10.1056/NEJM199002083220602 Quirt, 1991, Improved survival in patients with poor-prognosis malignant melanoma treated with adjuvant levamisole: a phase III study by the National Center Institute of Canada Clinical Trials Group, J. clin. Oncol., 9, 729, 10.1200/JCO.1991.9.5.729 Renoux, 1971, Immunologie: effect immunostimulant d'un imidothizole dans l'immunisation des souris contre l'infection par Brucella abortus, C.r. Acad. Sci. Paris, 272, 349 Renoux, 1972, Action du phenylimidothiazole (tetramisole) sur la réaction du graffon contre l'hôte. Rôle des macrophages, C.r. Acad. Sci. Paris, 274, 3320 Renoux, 1972, Immunologie: action immunostimulante de dérivés du phenylimidothiazole sur les cellules spleniques formatrices d'anticorps, C. r. Acad. Sci. Paris, 274, 756 Sarker, 1985, Follow-up study of adjuvant chemoimmunotherapy in colorectal carcinoma after definite surgery, Indian J. Cancer, 22, 113 Schnaper, 1984, Identification and initial characterisation of concanavalin-A and interferon induced human suppressor factors: evidence for a human equivalent of murine soluble immune response suppressor (SIRS), J. Immun., 132, 2429, 10.4049/jimmunol.132.5.2429 Spreafico, 1974, Selective antimetastatic treatment — current status and future prospects, Cancer Treat. Res., 1, 239, 10.1016/S0305-7372(74)80017-4 Stewart, 1978, Effect of levamisole in combination with radiotherapy in modifying the growth of murine tumors of differing immunogenicity, 11 Symoens, 1978, Adverse reactions to levamisole, Cancer Treat. Rep., 62, 1721 Tripodi, 1973, Drug-induced restoration of cutaneous delayed hypersensitivity in anergic patients with cancer, New Engl. J. Med., 289, 354, 10.1056/NEJM197308162890707 Van Wauwe, 1991, On the biochemical mode of action of levamisole: an update, Int. J. Immunopharmac., 13, 3, 10.1016/0192-0561(91)90019-4 Verhaegen, 1982, Levamisole therapy in patients with colorectal cancer, 225 Wakui, 1979, Experimental and clinical evaluation of chemo-immunotherapy for solid tumours, Jpn. J. Med., 18, 141, 10.2169/internalmedicine1962.18.141 Windle, 1987, Five year results of a randomized trial of adju 5-fluorouracil and levamisole in colorectal cancer, Br. J. Surg., 74, 569, 10.1002/bjs.1800740707 Windle, 1979, The effect of levamisole on postoperative immunosuppression, Br. J. Surg., 66, 507, 10.1002/bjs.1800660717