Leukotriene A4 hydrolase

Samuelsson, 1983, Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation, Science, 220, 568, 10.1126/science.6301011

Samuelsson, 1987, Leukotrienes and lipoxins: structures, biosynthesis, and biological effects, Science, 237, 1171, 10.1126/science.2820055

Ford-Hutchinson, 1980, Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes, Nature, 286, 264, 10.1038/286264a0

Griffiths, 1997, Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice, J. Exp. Med., 185, 1123, 10.1084/jem.185.6.1123

Bailie, 1996, Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities, J. Immunol., 157, 5221, 10.4049/jimmunol.157.12.5221

Mancuso, 2001, Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae, Infect. Immun., 69, 2011, 10.1128/IAI.69.4.2011-2016.2001

Chen, 1994, Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene, Nature, 372, 179, 10.1038/372179a0

Byrum, 1999, Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice, J. Immunol., 163, 6810, 10.4049/jimmunol.163.12.6810

Yokomizo, 1997, A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis, Nature, 387, 620, 10.1038/42506

Yokomizo, 2000, A second leukotriene B4 receptor, BLT2. A new therapeutic target in inflammation and immunological disorders, J. Exp. Med., 192, 421, 10.1084/jem.192.3.421

Devchand, 1996, The PPARα-leukotriene B4 pathway to inflammation control, Nature, 384, 39, 10.1038/384039a0

Haeggström, 2000, Structure, function, and regulation of LTA4 hydrolase, Am. J. Respir. Crit. Care Med., 161, S25, 10.1164/ajrccm.161.supplement_1.ltta-6

Malfroy, 1989, Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases, Biochem. Biophys. Res. Commun., 161, 236, 10.1016/0006-291X(89)91586-6

Vallee, 1990, Zinc coordination, function, and structure of zinc enzymes and other proteins, Biochemistry, 29, 5647, 10.1021/bi00476a001

Haeggström, 1990, Leukotriene A4 hydrolase: a zinc metalloenzyme, Biochem. Biophys. Res. Commun., 172, 965, 10.1016/0006-291X(90)91540-9

Minami, 1990, Leukotriene A4 hydrolase is a zinc-containing aminopeptidase, Biochem. Biophys. Res. Commun., 173, 620, 10.1016/S0006-291X(05)80080-4

Haeggström, 1990, Leukotriene A4 hydrolase: an epoxide hydrolase with peptidase activity, Biochem. Biophys. Res. Commun., 173, 431, 10.1016/S0006-291X(05)81076-9

Barret AJ, Rawlings ND, Woessner JF. Family M1 of membrane alanyl aminopeptidase. In: Barret AJ, Rawlings ND, Woessner JF, Barret AJ, Rawlings ND, Woessner JF, et al., editors. Handbook of proteolytic enzymes. London, San Diego: Academic Press, 1998. p. 994.

Orning, 1994, The bifunctional enzyme leukotriene A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity, J. Biol. Chem., 269, 11269, 10.1016/S0021-9258(19)78120-4

Wetterholm, 1992, Leukotriene A4 hydrolase: an anion activated peptidase, Biochim. Biophys. Acta, 1123, 275, 10.1016/0005-2760(92)90007-I

Örning, 1992, Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase, Biochemistry, 31, 4218, 10.1021/bi00132a010

Evans, 1985, Leukotriene A3: a poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase, J. Biol. Chem., 260, 10966, 10.1016/S0021-9258(17)39131-7

Ohishi, 1987, Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers, J. Biol. Chem., 262, 10200, 10.1016/S0021-9258(18)61098-1

Orning, 1992, Mechanism-based inactivation of leukotriene A4 hydrolase/aminopeptidase by leukotriene A4. Mass spectrometric and kinetic characterization, J. Biol. Chem., 267, 22733, 10.1016/S0021-9258(18)50009-0

Evans, 1992, Bestatin inhibits covalent coupling of [3H]LTA4 to human leukocyte LTA4 hydrolase, FEBS Lett., 297, 139, 10.1016/0014-5793(92)80345-H

Mueller, 1995, Leukotriene A4 hydrolase: mapping of a heneicosapeptide involved in mechanism-based inactivation, Proc. Natl. Acad. Sci. U.S.A., 92, 8383, 10.1073/pnas.92.18.8383

Mueller, 1996, Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378, Proc. Natl. Acad. Sci. U.S.A., 93, 5931, 10.1073/pnas.93.12.5931

Mueller, 1996, Leukotriene A4 hydrolase: mutation of tyrosine-383 allows conversion of leukotriene A4 into an isomer of leukotriene B4, J. Biol. Chem., 271, 24345, 10.1074/jbc.271.40.24345

Medina, 1991, Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site directed mutagenesis and zinc analysis, Proc. Natl. Acad. Sci. U.S.A., 88, 7620, 10.1073/pnas.88.17.7620

Pangburn, 1975, Thermolysin and neutral protease: mechanistic considerations, Biochemistry, 14, 4050, 10.1021/bi00689a019

Kester, 1977, Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis, Biochemistry, 16, 2506, 10.1021/bi00630a030

Wetterholm, 1992, Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296, Proc. Natl. Acad. Sci. U.S.A., 89, 9141, 10.1073/pnas.89.19.9141

Andberg, 2000, Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin, Biochem. J., 345, 621, 10.1042/bj3450621

Watt, 1989, Amino acid sequence deduced from rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N, J. Biol. Chem., 264, 5480, 10.1016/S0021-9258(18)83570-0

Minami, 1992, Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297, FEBS. Lett., 309, 353, 10.1016/0014-5793(92)80806-R

Blomster, 1995, Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase, Eur. J. Biochem., 231, 528, 10.1111/j.1432-1033.1995.0528d.x

Blomster Andberg, 1997, Mutation of tyrosine 383 in leukotriene A4 hydrolase allows formation of 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid: implications for the epoxide hydrolase mechanism, J. Biol. Chem., 272, 23057, 10.1074/jbc.272.37.23057

Thunnissen, 2001, Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation, Nat. Struct. Biol., 8, 131, 10.1038/84117

Rudberg PC, Tholander F, Thunnisen MGM, Haeggström JZ. Leukotriene A4 hydrolase/aminopeptidase: glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J Biol Chem 2002;277:1398–1404.

Vazeux, 1998, A glutamate residue contributes to the exo-peptidase specificity in aminopeptidase A, Biochem. J., 334, 407, 10.1042/bj3340407

Luciani, 1998, Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action, Biochemistry, 37, 686, 10.1021/bi971705p

Mueller, 1995, Chemical modification of leukotriene A4 hydrolase-indications for essential tyrosyl and arginyl residues at the active site, Biochemistry, 34, 3536, 10.1021/bi00011a007

Cadel, 1997, Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene A4 hydrolase, Proc. Natl. Acad. Sci. U.S.A., 94, 2963, 10.1073/pnas.94.7.2963

Fukasawa, 1999, Aminopeptidase B is structurally related to leukotriene A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity, Biochem. J., 339, 497, 10.1042/bj3390497

Green, 1987, Monohydroxyeicosatetraenoic acid and leukotriene production by the inflammatory cells of Xenopus laevis, J. Exp. Zool., 243, 211, 10.1002/jez.1402430206

Green, 1987, In vivo generation of 5-lipoxygenase products in frogs and toads, Biochem. Biophys. Res. Commun., 148, 1533, 10.1016/S0006-291X(87)80306-6

Pettitt, 1991, Synthesis of lipoxins and other lipoxygenase products by macrophages from the rainbow trout, Oncorhynchus mykiss, J. Biol. Chem., 266, 8720, 10.1016/S0021-9258(18)31505-9

Knight, 1995, Eicosanoid generating capacities of different tissues from the rainbow trout, Oncorhynchus mykiss, Lipids, 30, 451, 10.1007/BF02536304

Strömberg-Kull, 1998, Purification and characterization of leukotriene A4 hydrolase from Xenopus laevis oocytes, FEBS Lett., 433, 219, 10.1016/S0014-5793(98)00918-1

Nasr, 1996, Yeast, 12, 493, 10.1002/(SICI)1097-0061(199604)12:5<493::AID-YEA929>3.0.CO;2-W

Kull, 1999, Cloning and characterization of a bifunctional leukotriene A4 hydrolase from Saccharomyces cerevisiae, J. Biol. Chem., 274, 34683, 10.1074/jbc.274.49.34683

Kull, 2001, Leukotriene A4 hydrolase from Saccharomyces cerevisiae, formation of leukotriene B4 and identification of catalytic residues, Biochemistry, 40, 12695, 10.1021/bi011348p

Baset, 1998, Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases, J. Biol. Chem., 273, 27978, 10.1074/jbc.273.43.27978

Mancini, 1995, Cloning and characterization of the human leukotriene A4 hydrolase gene, Eur. J. Biochem., 231, 65, 10.1111/j.1432-1033.1995.tb20671.x

Ishizaka, 1999, Increased leukotriene A4 hydrolase expression in the heart of angiotensin II-induced hypertensive rat, FEBS Lett., 463, 155, 10.1016/S0014-5793(99)01607-5

Örning, 1991, Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril, J. Biol. Chem., 266, 16507, 10.1016/S0021-9258(18)55329-1

Penning, 1995, Kelatorphan and related analogs-potent and selective inhibitors of leukotriene A4 hydrolase, Bioorg. Med. Chem. Lett., 5, 2517, 10.1016/0960-894X(95)00441-U

Labaudinière, 1992, ω-[(ω-Arylalkyl)aryl]alkanoic acids: a new class of specific LTA4 hydrolase inhibitors, J. Med. Chem., 35, 3156, 10.1021/jm00095a010

Yuan, 1992, Novel tight-binding inhibitors of leukotriene A4 hydrolase, J. Am. Chem. Soc., 114, 6552, 10.1021/ja00042a041

Hogg, 1995, Amino hydroxamic acids as potent inhibitors of LTA4 hydrolase, Bioorg. Med. Chem. Lett., 3, 1405, 10.1016/0968-0896(95)00128-4

Wetterholm, 1995, Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes, J. Pharmacol. Exp. Ther., 275, 31

Yuan, 1996, Isolation and identification of metabolites of leukotriene A4 hydrolase inhibitor SC-57461 in rats, Drug Metab. Dispos., 24, 1124

Penning, 2000, Structure-activity relationship studies on 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A4 (LTA4) hydrolase, J. Med. Chem., 43, 721, 10.1021/jm990496z

Smith, 1996, Pharmacological characterization of selective inhibitors of leukotriene A4 hydrolase, Prostaglandins Leukot. Essent. Fatty Acids, 55, 13

Guex, 1997, SWISS-MODEL and the Swiss-PDB viewer: an environment for comparative protein modeling, Electrophoresis, 18, 2714, 10.1002/elps.1150181505

Altschul, 1997, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res., 25, 3389, 10.1093/nar/25.17.3389

Thompson, 1994, CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Res., 22, 4673, 10.1093/nar/22.22.4673