Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Cell Chemical Biology - Tập 25 Số 1 - Trang 78-87.e5 - 2018
Daniel P. Bondeson1, Blake E. Smith1, George M. Burslem1, Alexandru D. Buhimschi1, John Hines1, Saul Jaime‐Figueroa1, Jing Wang2, Brian D. Hamman2, Alexey Ishchenko2, Craig M. Crews1,3
1Department of Molecular Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT 06511, USA
2Arvinas, LLC, 5 Science Park, New Haven, CT 06511, USA
3Departments of Chemistry and Pharmacology, Yale University, New Haven, CT, USA

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