Les immune-checkpoints dans les hémopathies

Annales de Pathologie - Tập 37 - Trang 101-110 - 2017
Barbara Burroni1, Chloé Broudin1, Diane Damotte1,2,3,4, Camille Laurent5,6,7
1Service de pathologie, hôpital Cochin, AP–HP , 75014 Paris, France
2Inserm U1138, centre de recherche des Cordeliers, 15, rue de l’École de Médecine, 75006 Paris, France
3Université Paris Descartes, 75006, Paris, France
4Université Pierre-et-Marie-Curie, 75005 Paris, France
5Département de pathologie, institut universitaire du cancer–oncopole de Toulouse, 31059 Toulouse, France
6Service de pathologie et cytologie, centre hospitalier universitaire, 31300 Toulouse, France
7Inserm UMR1037, centre de recherches en cancérologie de Toulouse, 31100 Toulouse, France

Tài liệu tham khảo

Thanarajasingam, 2016, Immune checkpoint blockade in lymphoid malignancies, FEBS J, 283, 2233, 10.1111/febs.13668 Schreiber, 2005, Cancer vaccines 2004 opening address: the molecular and cellular basis of cancer immunosurveillance and immunoediting, Cancer Immun, 5, 1 Georgiou, 2016, Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas, Blood, 127, 3026, 10.1182/blood-2015-12-686550 Twa, 2015, Recurrent genomic rearrangements in primary testicular lymphoma: genomic rearrangements in primary testicular lymphoma, J Pathol, 236, 136, 10.1002/path.4522 Twa, 2014, Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma, Blood, 123, 2062, 10.1182/blood-2013-10-535443 Van Roosbroeck, 2016, Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies: JAK2 and PDL1/2 aberrations in lymphoma, Genes Chromosomes Cancer, 55, 428, 10.1002/gcc.22345 Green, 2012, Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy, Clin Cancer Res, 18, 1611, 10.1158/1078-0432.CCR-11-1942 Gupta, 2012, Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation, Blood, 119, 2844, 10.1182/blood-2011-10-388538 Kasprzycka, 2006, Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3, Proc Natl Acad Sci U S A, 103, 9964, 10.1073/pnas.0603507103 Chapuy, 2016, Targetable genetic features of primary testicular and primary central nervous system lymphomas, Blood, 127, 869, 10.1182/blood-2015-10-673236 Weniger, 2006, Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation, Oncogene, 25, 2679, 10.1038/sj.onc.1209151 Navarro, 2009, Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma, Blood, 114, 2945, 10.1182/blood-2009-02-204842 Marzec, 2008, Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1), Proc Natl Acad Sci U S A, 105, 20852, 10.1073/pnas.0810958105 Choi, 2013, MYD88 expression and L265P mutation in diffuse large B-cell lymphoma, Hum Pathol, 44, 1375, 10.1016/j.humpath.2012.10.026 Alizadeh, 2000, Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling, Nature, 403, 503, 10.1038/35000501 Ahearne, 2014, Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma, Virchows Arch Int J Pathol, 465, 351, 10.1007/s00428-014-1615-5 Kiyasu, 2015, Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma, Blood, 126, 2193, 10.1182/blood-2015-02-629600 Muenst, 2010, Diagnostic and prognostic utility of PD-1 in B cell lymphomas, Dis Markers, 29, 47, 10.1155/2010/404069 Laurent, 2015, Several immune escape patterns in non-Hodgkin's lymphomas, Oncoimmunology, 4, e1026530, 10.1080/2162402X.2015.1026530 Tonino, 2012, Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia, Leuk Lymphoma, 53, 1785, 10.3109/10428194.2012.673224 Xerri, 2008, Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia, Hum Pathol, 39, 1050, 10.1016/j.humpath.2007.11.012 Kwon, 2016, Clinicopathological analysis of programmed cell death 1 and programmed cell death ligand 1 expression in the tumour microenvironments of diffuse large B cell lymphomas, Histopathology, 68, 1079, 10.1111/his.12882 Andorsky, 2011, Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells, Clin Cancer Res, 17, 4232, 10.1158/1078-0432.CCR-10-2660 Chen, 2013, PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies, Clin Cancer Res, 19, 3462, 10.1158/1078-0432.CCR-13-0855 Laurent, 2016, Immune-checkpoint expression in Epstein-Barr virus positive and negative plasmablastic lymphoma: a clinical and pathological study in 82 patients, Haematologica, 101, 976, 10.3324/haematol.2016.141978 Magnoli, 2015, Primary testicular diffuse large B-cell lymphoma: morphological and immunophenotypical study with characterization of the T-cell component of the tumor microenvironment, Leuk Lymphoma, 1 Riemersma, 2005, High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis, J Pathol, 206, 328, 10.1002/path.1783 Rajnai, 2014, The density of CD8+ T-cell infiltration and expression of BCL2 predicts outcome of primary diffuse large B-cell lymphoma of bone, Virchows Arch Int J Pathol, 464, 229, 10.1007/s00428-013-1519-9 Berghoff, 2014, PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL), Clin Neuropathol, 33, 42, 10.5414/NP300698 Chapuy, 2016, Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease, Blood, 127, 2203, 10.1182/blood-2015-09-672352 Steidl, 2011, MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers, Nature, 471, 377, 10.1038/nature09754 Menter, 2016, Evaluation of the diagnostic and prognostic value of PDL1 expression in Hodgkin and B-cell lymphomas, Hum Pathol, 54, 17, 10.1016/j.humpath.2016.03.005 Dorfman, 2006, Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma, Am J Surg Pathol, 30, 802, 10.1097/01.pas.0000209855.28282.ce Richendollar, 2011, Follicular programmed death 1-positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma, Hum Pathol, 42, 552, 10.1016/j.humpath.2010.08.015 Ramsay, 2012, Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer, Blood, 120, 1412, 10.1182/blood-2012-02-411678 Carreras, 2009, High numbers of tumor-infiltrating programmed cell death 1 – positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma, J Clin Oncol, 27, 1470, 10.1200/JCO.2008.18.0513 Wahlin, 2010, A unifying microenvironment model in follicular lymphoma: outcome is predicted by programmed death-1 – positive, regulatory, cytotoxic, and helper T cells and macrophages, Clin Cancer Res, 16, 637, 10.1158/1078-0432.CCR-09-2487 Smeltzer, 2014, Pattern of CD14+ follicular dendritic cells and PD1+ T cells independently predicts time to transformation in follicular lymphoma, Clin Cancer Res, 20, 2862, 10.1158/1078-0432.CCR-13-2367 Laurent, 2011, Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study, Blood, 118, 5371, 10.1182/blood-2011-04-345777 Yang, 2015, PD-1 expression defines two distinct T-cell sub-populations in follicular lymphoma that differentially impact patient survival, Blood Cancer J, 5, e281, 10.1038/bcj.2015.1 Brusa, 2013, The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia, Haematologica, 98, 953, 10.3324/haematol.2012.077537 Swerdlow, 2016, The 2016 revision of the World Health Organization classification of lymphoid neoplasms, Blood, 127, 2375, 10.1182/blood-2016-01-643569 Wilcox, 2009, B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders, Blood, 114, 2149, 10.1182/blood-2009-04-216671 Brown, 2003, Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production, J Immunol, 170, 1257, 10.4049/jimmunol.170.3.1257 Cetinözman, 2012, Differential expression of programmed death-1 (PD-1) in Sézary syndrome and mycosis fungoides, Arch Dermatol, 148, 1379, 10.1001/archdermatol.2012.2089 Cetinözman, 2012, Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma, Am J Surg Pathol, 36, 109, 10.1097/PAS.0b013e318230df87 Kozako, 2009, PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients, Leukemia, 23, 375, 10.1038/leu.2008.272 Engert, 2012, Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial, Lancet, 379, 1791, 10.1016/S0140-6736(11)61940-5 Gordon, 2013, Randomized phase III trial of ABVD versus Stanford V with or without radiation therapy in locally extensive and advanced-stage Hodgkin lymphoma: an intergroup study coordinated by the Eastern Cooperative Oncology Group (E2496), J Clin Oncol, 31, 684, 10.1200/JCO.2012.43.4803 Evens, 2008, Treatment of Hodgkin lymphoma: the past, present, and future, Nat Clin Pract Oncol, 5, 543, 10.1038/ncponc1186 Montanari, 2015, Hodgkin lymphoma: targeting the tumor microenvironment as a therapeutic strategy, Clin Adv Hematol Oncol, 13, 518 Johnson, 2015, Modeling HLA associations with EBV-positive and -negative Hodgkin lymphoma suggests distinct mechanisms in disease pathogenesis, Int J Cancer, 137, 1066, 10.1002/ijc.29467 Pantanowitz, 2015, Microenvironment and HIV-related lymphomagenesis, Semin Cancer Biol, 34, 52, 10.1016/j.semcancer.2015.06.002 Reichel, 2015, Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells, Blood, 125, 1061, 10.1182/blood-2014-11-610436 Plattel, 2012, Plasma thymus and activation-regulated chemokine as an early response marker in classical Hodgkin's lymphoma, Haematologica, 97, 410, 10.3324/haematol.2011.053199 Yamamoto, 2008, PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma, Blood, 111, 3220, 10.1182/blood-2007-05-085159 Topalian, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, 366, 2443, 10.1056/NEJMoa1200690 Ansell, 2015, PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma, N Engl J Med, 372, 311, 10.1056/NEJMoa1411087 Koh, 2016, Programmed death 1 expression in the peritumoral microenvironment is associated with a poorer prognosis in classical Hodgkin lymphoma, Tumour Biol, 37, 7507, 10.1007/s13277-015-4622-5 Green, 2010, Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma, Blood, 116, 3268, 10.1182/blood-2010-05-282780 Steidl, 2010, Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome, Blood, 116, 418, 10.1182/blood-2009-12-257345 Muenst, 2009, Increased programmed death-1+ tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival, Hum Pathol, 40, 1715, 10.1016/j.humpath.2009.03.025 Muenst, 2015, The PD-1/PD-L1 pathway: biological background and clinical relevance of an emerging treatment target in immunotherapy, Expert Opin Ther Targets, 19, 201, 10.1517/14728222.2014.980235 Topalian, 2015, Immune checkpoint blockade: a common denominator approach to cancer therapy, Cancer Cell, 27, 450, 10.1016/j.ccell.2015.03.001