Leptospirosis: a zoonotic disease of global importance

The Lancet Infectious Diseases - Tập 3 Số 12 - Trang 757-771 - 2003
Ajay Bharti1, Jarlath E. Nally2, Jessica N. Ricaldi3, Michael A. Matthias1, M. Mónica Díaz4, Michael Lovett2, Paul N. Levett5, Robert H. Gilman6, Michael R. Willig4, Eduardo Gotuzzo3, Joseph M. Vinetz1
1Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA
2Division of Infectious Diseases, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA
3Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru
4Ecology Program, Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA
5Meningitis and Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
6Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA

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Vinetz, 2001, Leptospirosis, Curr Opin Infect Dis, 14, 527, 10.1097/00001432-200110000-00005

Trevejo, 1998, Epidemic leptospirosis associated with pulmonary haemorrhage—Nicaragua, 1995, J Infect Dis, 178, 1457, 10.1086/314424

O'Neil, 1991, Pulmonary manifestations of leptospirosis, Rev Infect Dis, 13, 705, 10.1093/clinids/13.4.705

Heron, 1997, Leptospirosis presenting as a haemorrhagic fever in a traveller from Africa, Med J Aust, 167, 477, 10.5694/j.1326-5377.1997.tb126675.x

Monzuez, 1997, Leptospirosis presenting as haemorrhagic fever in visitor to Africa, Lancet, 349, 254, 10.1016/S0140-6736(05)64865-9

Morgan, 2002, Outbreak of leptospirosis among triathlon participants and community residents in Springfield, Illinois, 1998, Clin Infect Dis, 34, 1593, 10.1086/340615

Haake, 2002, Leptospirosis, water sports, and chemoprophylaxis, Clin Infect Dis, 34, e40, 10.1086/339942

Sasaki, 1993, Active surveillance and risk factors for leptospirosis in Hawaii, Am J Trop Med Hyg, 48, 35, 10.4269/ajtmh.1993.48.35

Vinetz, 1996, Sporadic urban leptospirosis, Ann Intern Med, 125, 794, 10.7326/0003-4819-125-10-199611150-00002

Paster, 1991, Phylogenetic analysis of the spirochetes, J Bacteriol, 173, 6101, 10.1128/jb.173.19.6101-6109.1991

Dikken, 1978, Serological typing methods of leptospires, 259, 10.1016/S0580-9517(08)70493-8

Terpstra, 1992, Typing leptospira from the perspective of a reference laboratory, Acta Leiden, 60, 79

Yasuda, 1987, Deoxyribonucleic acid relatedness between serogroups and serovars in the family Leptospiraceae with proposals for seven new Leptospira species, Int J Syst Bacteriol, 37, 407, 10.1099/00207713-37-4-407

Ramadass, 1992, Genetic characterization of pathogenic Leptospira species by DNA hybridization, Int J Syst Bacteriol, 42, 215, 10.1099/00207713-42-2-215

Brenner, 1999, Further determination of DNA relatedness between serogroups and serovars in the family Leptospiraceae with a proposal for Leptospira alexanderi sp nov and four new Leptospira genomospecies, Int J Syst Bacteriol, 49, 839, 10.1099/00207713-49-2-839

Perolat, 1998, Leptospira fainei sp nov, isolated from pigs in Australia, Int J Syst Bacteriol, 48, 851, 10.1099/00207713-48-3-851

Boursaux-Eude, 1998, Leptospira genomics, Electrophoresis, 19, 589, 10.1002/elps.1150190421

Ren, 2003, Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing, Nature, 422, 888, 10.1038/nature01597

Fraser, 1998, Complete genome sequence of Treponema pallidum, the syphilis spirochete, Science, 281, 375, 10.1126/science.281.5375.375

Fraser, 1997, Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi., Nature, 390, 580, 10.1038/37551

de la Pena-Moctezuma, 1999, Comparative analysis of the LPS biosynthetic loci of the genetic subtypes of serovar hardjo: Leptospira interrogans subtype hardjoprajitno and Leptospira borgpetersenii subtype hardjobovis., FEMS Microbiol Lett, 177, 319, 10.1016/S0378-1097(99)00333-X

Saint Girons, 2000, The LE1 bacteriophage replicates as a plasmid within Leptospira biflexa: construction of an L biflexa-Escherichia coli shuttle vecto, J Bacteriol, 182, 5700, 10.1128/JB.182.20.5700-5705.2000

Haake, 2000, Spirochaetal lipoproteins and pathogenesis, Microbiology, 146, 1491, 10.1099/00221287-146-7-1491

Hovind-Hougen, 1976, Determination by means of electron microscopy of morphological criteria of value for classification of some spirochetes, in particular treponemes, Acta Pathol Microbiol Scand, 255, 1

Charon, 2002, Genetics of motility and chemotaxis of a fascinating group of bacteria: The spirochetes, Annu Rev Genet, 36, 47, 10.1146/annurev.genet.36.041602.134359

Ellis, 1983, Morphological changes upon subculturing of freshly isolated strains of Leptospira interrogans serovar hardjo., Zentralbl Bakteriol Mikrobiol Hyg [A], 255, 323

Ellis, 1976, Bovine leptospirosis: a serological and clinical study, Vet Rec, 99, 387, 10.1136/vr.99.20.387

Faine, 1999

Ellinghausen, 1965, Nutrition of Leptospira pomona and growth of 13 other serotypes: fractionation of oleic albumin complex and a medium of bovine albumin and polysorbate 80, Am J Vet Res, 26, 45

Ellinghausen, 1965, Nutrition of Leptospira pomona and growth of 13 other serotypes: a serum-free medium employing oleic albumin complex, Am J Vet Res, 26, 39

Johnson, 1967, Metabolism of leptospires II. The action of 8-azaguanine, Can J Microbiol, 13, 1621, 10.1139/m67-212

Levett, 2001, Leptospirosis, Clin Microbiol Rev, 14, 296, 10.1128/CMR.14.2.296-326.2001

Kmety, 1993, Classification of the species Leptospira interrogans and the history of its serovars

Bovet, 1999, Factors associated with clinical leptospirosis: a population-based case-control study in the Seychelles (Indian Ocean), Int J Epidemiol, 28, 583, 10.1093/ije/28.3.583

Ashford, 2000, Asymptomatic infection and risk factors for leptospirosis in Nicaragua, Am J Trop Med Hyg, 63, 249, 10.4269/ajtmh.2000.63.249

Leonard, 1992, K OF. Duration of urinary excretion of leptospires by cattle naturally or experimentally infected with Leptospira interrogans serovar hardjo., Vet Rec, 131, 435, 10.1136/vr.131.19.435

Thiermann, 1981, The Norway rat as a selective chronic carrier of Leptospira icterohaemorrhagiae, J Wildl Dis, 17, 39, 10.7589/0090-3558-17.1.39

Matthias, 2002, Leptospiral carriage by mice and mongooses on the island of Barbados, West Indian Med J, 51, 10

Tomich, 1979, Studies of leptospirosis in natural host populations I. Small mammals of Waipio Valley, island of Hawaii, Pacific Science, 33, 257

Alexander, 1963, Leptospirosis in Puerto Rico, Zoonoses Res, 2, 152

Sulzer, 1975

Everard, 1980, Pathogenic leptospira isolates from the Caribbean Islands of Trinidad, Grenada and St Vincent, Int J Zoonoses, 7, 90

Everard, 1976, Leptospirosis in Trinidad and Grenada, with special reference to the mongoose, Trans R Soc Trop Med Hyg, 70, 57, 10.1016/0035-9203(76)90008-0

Ko, 1999, Urban epidemic of severe leptospirosis in Brazil, Lancet, 354, 820, 10.1016/S0140-6736(99)80012-9

St John, 2000, Leptospirosis occurring in two children after fresh water immersion, West Indian Med J, 49, 340

Sanders, 1999, Increase of leptospirosis in dengue-negative patients after a hurricane in Puerto Rico in 1996 [correction of 1966], Am J Trop Med Hyg, 61, 399, 10.4269/ajtmh.1999.61.399

Bunnell, 2000, Detection of pathogenic Leptospira spp infections among mammals captured in the Peruvian Amazon basin region, Am J Trop Med Hyg, 63, 255, 10.4269/ajtmh.2000.63.255

Russell, 2003, An outbreak of leptospirosis among Peruvian military recruits, Am J Trop Med Hyg, 69, 53, 10.4269/ajtmh.2003.69.53

Sejvar, 2003, Leptospirosis in Eco-Challenge Athletes, Malaysian Borneo, 200, Emerg Infect Dis, 9, 702, 10.3201/eid0906.020751

Levett, 1998, Surveillance of leptospiral carriage by feral rats in Barbados, West Indian Med J, 47, 15

Willig, 2001, Common trends with latitude, 701

Willig MR, Kaufman MD, Stevens RD. Latitudinal gradients of biodiversity: pattern, process, scale, and synthesis. Annu Rev Ecol Syst (in press)

Lux, 2000, Chemotaxis in pathogenic spirochetes: directed movement toward targeting tissues?, J Mol Microbiol Biotechnol, 2, 355

Yuri, 1993, Chemotaxis of leptospires to hemoglobin in relation to virulence, Infect Immun, 61, 2270, 10.1128/IAI.61.5.2270-2272.1993

Bernheimer, 1986, Copurification of Leptospira interrogans serovar pomona hemolysin and sphingomyelinase C, Infect Immun, 54, 262, 10.1128/IAI.54.1.262-264.1986

del Real, 1989, Cloning of a hemolysin gene from Leptospira interrogans serovar hardjo., Infect Immun, 57, 2588, 10.1128/IAI.57.8.2588-2590.1989

Segers, 1990, Molecular analysis of a sphingomyelinase C gene from Leptospira interrogans serovar hardjo., Infect Immun, 58, 2177, 10.1128/IAI.58.7.2177-2185.1990

Lee, 2002, Cytotoxic activities of Leptospira interrogans hemolysin SphH as a poreforming protein on mammalian cells, Infect Immun, 70, 315, 10.1128/IAI.70.1.315-322.2002

Merien, 2000, Identification of a 36-kDa fibronectin-binding protein expressed by a virulent variant of Leptospira interrogans serovar icterohaemorrhagiae., FEMS Microbiol Lett, 185, 17, 10.1111/j.1574-6968.2000.tb09034.x

Nally, 2001, Molecular characterization of thermoinduced immunogenic proteins Q1p42 and Hsp15 of Leptospira interrogans, Infect Immun, 69, 7616, 10.1128/IAI.69.12.7616-7624.2001

Nally, 2001, Temperatureregulated protein synthesis by Leptospira interrogans, Infect Immun, 69, 400, 10.1128/IAI.69.1.400-404.2001

Cullen, 2002, Global analysis of outer membrane proteins from Leptospira interrogans serovar lai, Infect Immun, 70, 2311, 10.1128/IAI.70.5.2311-2318.2002

Palaniappan, 2002, Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogans., Infect Immun, 70, 5924, 10.1128/IAI.70.11.5924-5930.2002

Harkin, 2003, Comparison of polymerase chain reaction assay, bacteriologic culture, and serologic testing in assessment of prevalence of urinary shedding of leptospires in dogs, J Am Vet Med Assoc, 222, 1230, 10.2460/javma.2003.222.1230

Talpada, 2003, Prevalence of leptospiral infection in Texas cattle: implications for transmission to humans, Vector Borne Zoonotic Dis, 3, 141, 10.1089/153036603768395843

Yang, 2000, Leptospira outer membrane protein activates NF-kappaB and downstream genes expressed in medullary thick ascending limb cells, J Am Soc Nephrol, 11, 2017, 10.1681/ASN.V11112017

Barnett, 1999, Expression and distribution of leptospiral outer membrane components during renal infection of hamsters, Infect Immun, 67, 853, 10.1128/IAI.67.2.853-861.1999

Werts, 2001, Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism, Nat Immunol, 2, 346, 10.1038/86354

Silva, 2002, Clinicopathological and immunohistochemical features of the severe pulmonary form of leptospirosis, Rev Soc Bras Med Trop, 35, 395, 10.1590/S0037-86822002000400017

Alves, 1992, Leptospiral antigens in the liver of experimentally infected guinea pig and their relation to the morphogenesis of liver damage, Exp Toxicol Pathol, 44, 425, 10.1016/S0940-2993(11)80185-5

Alves, 1991, Leptospiral antigens L interrogans serogroup icterohaemorrhagiae in the kidney of experimentally infected guinea-pigs and their relation to the pathogenesis of renal injury, Exp Pathol, 42, 81, 10.1016/S0232-1513(11)80051-4

Diament, 2002, Peripheral blood mononuclear cell activation induced by Leptospira interrogans glycolipoprotein, Infect Immun, 70, 1677, 10.1128/IAI.70.4.1677-1683.2002

Younes-Ibrahim, 1995, Inhibition of Na, K-ATPase by an endotoxin extracted from Leptospira interrogans: a possible mechanism for the physiopathology of leptospirosis, C R Acad Sci III, 318, 619

Beamer, 1939, Histopathology of experimental leptospirosis, Am J Path, 23, 896

Hu, 1985, Relationship between the number of leptospires in blood, livers and lungs of guinea pigs and the pulmonary diffuse haemorrhage of leptospirosis, Sichuan Yi Xue Yuan Xue Bao, 16, 33

Miller, 1974, The pathogenesis of haemorrhage in the lung of the hamster during acute leptospirosis, Med Microbiol Immunol, 160, 269, 10.1007/BF02121442

Abdulkader, 2002, Leptospirosis severity may be associated with the intensity of humoral immune response, Rev Inst Med Trop Sao Paulo, 44, 79, 10.1590/S0036-46652002000200005

Edwards, 1986, Thrombocytopenia in leptospirosis: the absence of evidence for disseminated intravascular coagulation, Am J Trop Med Hyg, 35, 352, 10.4269/ajtmh.1986.35.352

Jaroonvesama, 1975, Coagulation studies in leptospirosis, Southeast Asian J Trop Med Public Health, 6, 562

Nicodemo, 1997, Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia, Am J Trop Med Hyg, 56, 181, 10.4269/ajtmh.1997.56.181

Higgins, 1977, The pathogenesis of leptospirosis II. Jaundice in experimental leptospirosis in guinea-pigs, Can J Comp Med, 41, 182

da Silva, 1995, The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs, Rev Soc Bras Med Trop, 28, 169, 10.1590/S0037-86821995000300002

Rathinam, 1997, Uveitis associated with an epidemic outbreak of leptospirosis, Am J Ophthalmol, 124, 71, 10.1016/S0002-9394(14)71646-0

Faber, 2000, Detection of Leptospira spp in the aqueous humor of horses with naturally acquired recurrent uveitis, J Clin Microbiol, 38, 2731, 10.1128/JCM.38.7.2731-2733.2000

Brem, 1998, Demonstration of intraocular leptospira in 4 horses suffering from equine recurrent uveitis (ERU), Berl Munch Tierarztl Wochenschr, 111, 415

Parma, 1992, C3 fixed in vivo to cornea from horses inoculated with Leptospira interrogans., Vet Immunol Immunopathol, 34, 181, 10.1016/0165-2427(92)90161-I

Brem, 1999, 35 leptospira isolated from the vitreous body of 32 horses with recurrent uveitis (ERU), Berl Munch Tierarztl Wochenschr, 112, 390

Adler, 1977, Host immunological mechanisms in the resistance of mice to leptospiral infections, Infect Immun, 17, 67, 10.1128/IAI.17.1.67-72.1977

Sonrier, 2000, Evidence of crossprotection within Leptospira interrogans in an experimental model, Vaccine, 19, 86, 10.1016/S0264-410X(00)00129-8

Adler, 1979, Serological cross-reactions of leptospiral lipopolysaccharide (F4) antigen, Zentralbl Bakteriol [Orig A], A244, 291

Haake, 1999, Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection, Infect Immun, 67, 6572, 10.1128/IAI.67.12.6572-6582.1999

Truccolo, 2001, Following the course of human leptospirosis: evidence of a critical threshold for the vital prognosis using a quantitative PCR assay, FEMS Microbiol Lett, 204, 317, 10.1111/j.1574-6968.2001.tb10904.x

Naiman, 2001, Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and gamma-delta T lymphocytes, Infect Immun, 69, 7550, 10.1128/IAI.69.12.7550-7558.2001

Pereira, 1998, Morphological characterisation of lung and kidney lesions in C3H/HeJ mice infected with Leptospira interrogans serovar icterohaemorrhagiae: defect of CD4+ and CD8+ T-cells are prognosticators of the disease progression, Exp Toxicol Pathol, 50, 191, 10.1016/S0940-2993(98)80083-3

Klimpel, 2003, Leptospira interrogans activation of human peripheral blood mononuclear cells: preferential expansion of TCRgammadelta(+) T cells vs TCRalphabeta(+) T cells, J Immunol, 171, 1447, 10.4049/jimmunol.171.3.1447

Farr, 1995, Leptospirosis, Clin Infect Dis, 21, 1, 10.1093/clinids/21.1.1

Heath J, 1961, Leptospirosis in the United States, New Engl J Med, 273, 857, 10.1056/NEJM196510142731606

Takafuji, 1984, An efficacy trial of doxycycline chemoprophylaxis against leptospirosis, N Engl J Med, 310, 497, 10.1056/NEJM198402233100805

Bolin, 1988, Human-to-human transmission of Leptospira interrogans by milk, J Infec Dis, 158, 246, 10.1093/infdis/158.1.246

Katz, 2001, Assessment of the clinical presentation and treatment of 353 cases of laboratory-confirmed leptospirosis in Hawaii, 1974–1998, Clin Infect Dis, 33, 1834, 10.1086/324084

Panicker, 2001, Primary neuroleptospirosis, Postgrad Med J, 77, 589, 10.1136/pmj.77.911.589

Heath, 1965, Leptospirosis in the United States. Analysis of 483 cases in man, 1949–1961, N Engl J Med, 273, 857, 10.1056/NEJM196510142731606

Moseley, 1997, Sepsis-associated cholestasis, Gastroenterology, 112, 302, 10.1016/S0016-5085(97)70250-6

Abdulkader, 1997, Acute renal failure in leptospirosis, Ren Fail, 19, 191, 10.3109/08860229709026275

Daher, 1999, Risk factors for death and changing patterns in leptospirosis acute renal failure, Am J Trop Med Hyg, 61, 630, 10.4269/ajtmh.1999.61.630

Edwards, 1999, Leptospirosis and pancreatitis, Pediatr Infect Dis J, 18, 399, 10.1097/00006454-199904000-00027

Edwards, 1982, Thrombocytopenia in leptospirosis, Am J Trop Med Hyg, 31, 827, 10.4269/ajtmh.1982.31.827

Hill, 1997, Leptospiral pneumonia, Sem Resp Infect, 12, 44

Im, 1989, Leptospirosis of the lung: radiographic findings in 58 patients, Am J Roentgenol, 152, 955, 10.2214/ajr.152.5.955

Dupont, 1997, Leptospirosis: prognostic factors associated with mortality, Clin Infect Dis, 25, 720, 10.1086/513767

Marotto, 1999, Acute lung injury in leptospirosis: clinical and laboratory features, outcome, and factors associated with mortality, Clin Infect Dis, 29, 1561, 10.1086/313501

Parsons, 1965, Electrocardiographic changes in leptospirosis, BMJ, 2, 201, 10.1136/bmj.2.5455.201

Charon, 1975, Antileptospiral activity in lower-vertebrate sera, Infect Immun, 12, 1386, 10.1128/IAI.12.6.1386-1391.1975

Coursin, 2000, Massive rhabdomyolysis and multiple organ dysfunction syndrome caused by leptospirosis, Intensive Care Med, 26, 808, 10.1007/s001340051252

Ho, 1980, Acute rhabdomyolysis and renal failure in Weil's disease, Ala J Med Sci, 17, 133

Rathinam, 2002, Ocular leptospirosis, Curr Opin Ophthalmol, 13, 381, 10.1097/00055735-200212000-00007

Barkay, 1984, Leptospirosis and uveitis, Ann Ophthalmol, 16, 164

Chu, 1998, Identification of Leptospira species in the pathogenesis of uveitis and determination of clinical ocular characteristics in South India, J Infect Dis, 177, 1314, 10.1086/515273

Monsuez, 1997, Leptospirosis presenting as haemorrhagic fever in visitor to Africa, Lancet, 349, 254, 10.1016/S0140-6736(05)64865-9

Heron, 1997, Leptospirosis presenting as a haemorrhagic fever in a traveller from Africa, Med J Aust, 167, 477, 10.5694/j.1326-5377.1997.tb126675.x

Watt, 2003, Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis, Am J Trop Med Hyg, 68, 89, 10.4269/ajtmh.2003.68.89

Levett, 2003, Usefulness of serologic analysis as a predictor of the infecting serovar in patients with severe leptospirosis, Clin Infect Dis, 36, 447, 10.1086/346208

Faine, 1982

Weyant, 1999, Leptospira and leptonema, 739

Wolff, 1954

Palmer, 1984, Survival of leptospires in commercial blood culture systems, Zentralbl Bakteriol Mikrobiol Hyg [A], 257, 480

Palmer, 2000, Survival of leptospires in commercial blood culture systems revisited, J Clin Pathol, 53, 713, 10.1136/jcp.53.9.713

Smythe, 2002, A quantitative PCR (TaqMan) assay for pathogenic Leptospira spp, BMC Infect Dis, 2, 13, 10.1186/1471-2334-2-13

Cumberland, 1999, Assessment of the efficacy of an IgM-elisa and microscopic agglutination test (MAT) in the diagnosis of acute leptospirosis, Am J Trop Med Hyg, 61, 731, 10.4269/ajtmh.1999.61.731

Cole, 1973, Improved microtechnique for the leptospiral microscopic agglutination test, Appl Microbiol, 25, 976, 10.1128/AEM.25.6.976-980.1973

Levett, 2001, Two methods for rapid serological diagnosis of acute leptospirosis, Clin Diagn Lab Immunol, 8, 349, 10.1128/CDLI.8.2.349-351.2001

Adler, 1980, Detection of specific anti-leptospiral immunoglobulins M and G in human serum by solid-phase enzyme-linked immunosorbent assay, J Clin Microbiol, 11, 452, 10.1128/JCM.11.5.452-457.1980

Terpstra, 1985, ELISA for the detection of specific IgM and IgG in human leptospirosis, J Gen Microbiol, 131, 377

Watt, 1988, Placebocontrolled trial of intravenous penicillin for severe and late leptospirosis, Lancet, 1, 433, 10.1016/S0140-6736(88)91230-5

Flannery, 2001, Evaluation of recombinant leptospira antigen-based enzymelinked immunosorbent assays for the serodiagnosis of leptospirosis, J Clin Microbiol, 39, 3303, 10.1128/JCM.39.9.3303-3310.2001

Winslow, 1997, Evaluation of a commercial enzyme-linked immunosorbent assay for detection of immunoglobulin M antibody in diagnosis of human leptospiral infection, J Clin Microbiol, 35, 1938, 10.1128/JCM.35.8.1938-1942.1997

Smits, 1999, International multicenter evaluation of the clinical utility of a dipstick assay for detection of leptospiraspecific immunoglobulin M antibodies in human serum specimens, J Clin Microbiol, 37, 2904, 10.1128/JCM.37.9.2904-2909.1999

Levett, 2002, Evaluation of two enzymelinked immunosorbent assay methods for detection of immunoglobulin M antibodies in acute leptospirosis, Am J Trop Med Hyg, 66, 745, 10.4269/ajtmh.2002.66.745

Bajani, 2003, Evaluation of four commercially available rapid serologic tests for diagnosis of leptospirosis, J Clin Microbiol, 41, 803, 10.1128/JCM.41.2.803-809.2003

Vinetz, 2003, A Mountain out of a molehill: do we treat acute leptospirosis, and if so, with what?, Clin Infect Dis, 36, 1514, 10.1086/375275

Edwards, 1988, Penicillin therapy in icteric leptospirosis, Am J Trop Med Hyg, 39, 388, 10.4269/ajtmh.1988.39.388

Guidugli, 2000, Systematic reviews on leptospirosis, Rev Inst Med Trop Sao Paulo, 42, 47, 10.1590/S0036-46652000000100008

Guidugli, 2000, Antibiotics for preventing leptospirosis, Cochrane Database Syst Rev

Panaphut, 2003, Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis, Clin Infect Dis, 36, 1507, 10.1086/375226

Truccolo, 2002, Quantitative PCR assay to evaluate ampicillin, ofloxacin, and doxycycline for treatment of experimental leptospirosis, Antimicrob Agents Chemother, 46, 848, 10.1128/AAC.46.3.848-853.2002

Hospenthal, 2003, In vitro susceptibilities of seven Leptospira species to traditional and newer antibiotics, Antimicrob Agents Chemother, 47, 2646, 10.1128/AAC.47.8.2646-2648.2003

Sehgal, 2000, Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area, Int J Antimicrob Agents, 13, 249, 10.1016/S0924-8579(99)00134-X

Bharadwaj, 2002, An urban outbreak of leptospirosis in mumbai, India, Jpn J Infect Dis, 55, 194

Martinez Sanchez, 1998, The reactogenicity and immunogenicity of the first Cuban vaccine against human leptospirosis, Rev Cubana Med Trop, 50, 159

Martinez Sanchez, 2000, Evaluation of the effectiveness of a new vaccine against human leptospirosis in groups at risk, Rev Panam Salud Publica, 8, 385

Ikoev, 1999, The evaluation of the reactogenicity and immunogenic activity of a new concentrated inactivated leptospirosis vaccine, Zh Mikrobiol Epidemiol Immunobiol, 39

Chen, 1985, Development and situation of and techniques for production of leptospirosis vaccine in China, Jpn J Bacteriol, 40, 755, 10.3412/jsb.40.755

Petersen, 2001, First isolation of Leptospira fainei serovar hurstbridge from two human patients with Weil's syndrome, J Med Microbiol, 50, 96, 10.1099/0022-1317-50-1-96

Frolov, 1996, Clinical assessment of autoimmune and immunocomplex reactions in patients with leptospirosis, Klin Med (Mosk), 74, 68

Alexander, 1990, Etiology and occurrence of periodic eye inflammation of horses in the area of Berlin, Tierarztl Prax, 18, 623

Feigin, 1973, Human leptospirosis from immunized dogs, Ann Intern Med, 79, 777, 10.7326/0003-4819-79-6-777

Bolin, 2001, Use of a monovalent leptospiral vaccine to prevent renal colonization and urinary shedding in cattle exposed to Leptospira borgpetersenii serovar hardjo., Am J Vet Res, 62, 995, 10.2460/ajvr.2001.62.995

Guerreiro, 2001, Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans, Infect Immun, 69, 4958, 10.1128/IAI.69.8.4958-4968.2001