Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway
Tóm tắt
Từ khóa
Tài liệu tham khảo
Loffreda S, Rai R, Yang SQ, et al. Leptin regulates proinflammatory immune responses. FASEB J. 1998;12:57–65.
Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol. 1999;194:6–11.
Martin-Romero C, Santos-Alvarez J, Governa R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol. 2000;199:15–24.
Mattioli B, Straface E, Quaranta MG, Giordani L, Viora M. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J Immunol. 2005;174:6820–8.
Pistoia V. Production of cytokines by human B cells in health and disease. Immunol Today. 1997;18:343–50.
Tumanov AV, Kuprash DV, Mach JA, Nedospasov SA, Chervonsky AV. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium bur are required for development of follicles in the Peyer's patches. J Immunol. 2004;173:86–91.
Harris DP, Hyanes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, et al. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol. 2000;1:475–82.
Agrawal S, and Gupta S. TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J. Clin. Immunol. 2010 Sep 7. PMID: 20821041 (in press)
Gabay C, Dreyer MG, Pellegrinelli N, Chicheportiche R, Meier CA. Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes. J Clin Endocrinol Metab. 2001;86:683–791.
Sanchez-Margallet V, Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol. 2001;211:30–6.
Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB et al. Recombinant methionyl human Leptin activates STAT3 signaling in PBMCs in vivo and regulates soluble TNF-α receptor levels in humans with relative leptin deficiency. J. Clin. Endocr. Metabol. 2005;90:1625–31.
Bjorbaek C, Uotani S, da Silva B, Flier J. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem. 1997;272:32686–95.
Zabeau L, Defeau D, Van der Heyden J, Iserentant H, Candekerckhove J, Tavernier J. Functional analysis of leptin receptor activation using a Janus kiase/signal transducer and activator of transcription complementation assay. Mol Endocrinol. 2004;18:150–61.
Leptin receptor (OB-R) oligomerizes with itself but not with its closey relate cytokine signal transducer gp 130. FEBS Lett. 403:79-82, 1997
Procaccini C, Lourenco EV, Matarese G, La Cava A. Leptin signaling: a key pathway in immune responses. Curr Signal Transduct Ther. 2009;4:22–30.
Shen J, Sakaida I, Uchida K, Terai S, Okita K. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kuffer cells. Life Sci. 2005;77:1502–15.
Gao J, Tian J, Lv Y, Shi F, Kong F, Shi H, et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci. 2009;100(3):389–95.
Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D, et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res. 2007;67(6):2497–507.
Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation and hematopoiesis. J Leukoc Biol. 2000;68:437–46.
Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394:897–901.
Zhao Y, Sun R, You L, Gao C, Toan Z. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res Commun. 2002;300:247–52.
Sanchez-Margalet V, Martin-Romero C, Santos-Alvarez J, Goberma R, Najib S, Gonzalez-Yanes C. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol. 2003;133:11–9.
Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D, et al. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol. 2002;168:875–82.
Lord GM, Matarese G, Howard JK, Bloom SR, and Lechler RL. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. J. Leuco. Biol. 2002;72:330.
Spencer NF, Daynes RA. IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells; possible involvement in age-associated cytokine dysregulation. Int Immunol. 1997;9:745–54.
Kloek C, Haq AK, Dunn SL, Lavery HJ, Bank AS, Myers MG. Regulation of JAK kinases by intracellular leptin receptor sequences. J Biol Chem. 2002;277:41547–55.
Hekerman P, Zeidler J, Bamberg-Lemper S, et al. Peliotropy of leptin receptor signaling is defined by distinct roles of the intracellular tyrosines. FEBS J. 2005;272:109–19.
Bjorbaek C, Buchhol RM, Davis SM, et al. The role of SHP-2 in MAPK activation by leptin receptor. J Biol Chem. 2001;276:4747–55.
Takahasi Y, Okimura Y, Mizuno I, et al. Leptin induces mitogen-activated protein kinase-dependent proliferation C3H10T1/2 cells. J Biol Chem. 1997;272:12897–900.
Keller M, Koch M, Metzinger E, Mushak J, Capp E, Haring HU. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia. 1997;40:1358–62.
Harvey J, McKay NG, Walker KS, Van der Kaay J, Downes CP, Ashford MLF. Essential role of Phosphoinositide 3-kinase in leptin-induced K channel activation in the rat CRI-G1 insulinoma cell line. J Biol Chem. 2000;275:4660–9.
Martin-Romero C, Sanchez-Margalet V. Human leptin activates P13K and MAPK pathways in human peripheral blood mononuclear cells. Possible role of Sam68. Cell Immunol. 2001;212:83–91.
Dreyer MG, Juge-Aubry CE, Gabay C, et al. Leptin activates the promoter of the interleukin-1 receptor antagonist through p42/44 mitogen-activated protein kinase and a composite nuclear factor kappaB/PU. I. Binding site. Biochem J. 2003;370:591–9.