Latest developments in tryptophan metabolism: Understanding its role in B cell immunity

Cytokine & Growth Factor Reviews - Tập 59 - Trang 111-117 - 2021
Xavier Dagenais-Lussier1, Hamza Loucif1, Cherifa Beji1, Roman Telittchenko1, Jean-Pierre Routy2, Julien van Grevenynghe1
1Institut National de la Recherche Scientifique (INRS)-Armand-Frappier Santé Biotechnologie, 531 Boulevard des Prairies, Laval, H7V 1B7, QC, Canada
2Chronic Viral Illness Service and Division of Hematology, McGill University Health Centre, Glen site, Montréal, Québec, Canada

Tài liệu tham khảo

Moffett, 2003, Tryptophan and the immune response, Immunol. Cell Biol., 81, 247, 10.1046/j.1440-1711.2003.t01-1-01177.x Gostner, 2020, Tryptophan metabolism and related pathways in psychoneuroimmunology: the impact of nutrition and lifestyle, Neuropsychobiology, 79, 89, 10.1159/000496293 Fuchs, 1991, Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection, Immunol. Lett., 28, 207, 10.1016/0165-2478(91)90005-U Favre, 2010, Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease, Sci. Transl. Med., 2, 10.1126/scitranslmed.3000632 Jenabian, 2014, Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection, Clin. Exp. Immunol., 178, 102, 10.1111/cei.12396 Jenabian, 2015, Montreal primary infection and slow progressor study groups, immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection, J. Infect. Dis., 212, 355, 10.1093/infdis/jiv037 Chen, 2014, Anti-retroviral therapy decreases but does not normalize indoleamine 2,3-dioxygenase activity in HIV-infected patients, PLoS One, 9 Gaardbo, 2015, Increased tryptophan catabolism is associated with increased frequency of CD161+Tc17/MAIT cells and lower CD4+ T-Cell count in HIV-1 infected patients on cART after 2 years of follow-up, J. Acquir. Immune Defic. Syndr. 1999, 70, 228, 10.1097/QAI.0000000000000758 Bipath, 2015, The kynurenine pathway activities in a sub-Saharan HIV/AIDS population, BMC Infect. Dis., 15, 346, 10.1186/s12879-015-1087-5 Dagenais-Lussier, 2016, Kynurenine reduces memory CD4 T-Cell survival by interfering with interleukin-2 signaling early during HIV-1 infection, J. Virol., 90, 7967, 10.1128/JVI.00994-16 Boasso, 2007, HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells, Blood, 109, 3351, 10.1182/blood-2006-07-034785 Planès, 2013, HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation, PLoS One, 8, 10.1371/journal.pone.0074551 Widner, 2000, Enhanced tryptophan degradation in systemic lupus erythematosus, Immunobiology, 201, 621, 10.1016/S0171-2985(00)80079-0 Schroecksnadel, 2003, Increased degradation of tryptophan in blood of patients with rheumatoid arthritis, J. Rheumatol., 30, 1935 Pertovaara, 2007, Indoleamine 2.,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season, Clin. Exp. Immunol., 150, 274, 10.1111/j.1365-2249.2007.03480.x Perl, 2015, Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin, Metabolomics Off. J. Metabolomic Soc., 11, 1157 Aeinehband, 2016, Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms, Brain Behav. Immun., 51, 47, 10.1016/j.bbi.2015.07.016 Lim, 2017, Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression, Sci. Rep., 7, 41473, 10.1038/srep41473 Åkesson, 2018, Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, Lupus Sci. Med., 5, 10.1136/lupus-2017-000254 Gaetani, 2020, Host and microbial tryptophan metabolic profiling in multiple sclerosis, Front. Immunol., 11, 157, 10.3389/fimmu.2020.00157 Vyboh, 2015, HIV and the gut microbiota, partners in crime: breaking the vicious cycle to unearth new therapeutic targets, J. Immunol. Res., 9 Amobi, 2017, Tryptophan catabolism and cancer immunotherapy targeting IDO mediated immune suppression, 129 Prendergast, 2018, Indoleamine 2,3-dioxygenase and its therapeutic inhibition in cancer, 175, 10.1016/bs.ircmb.2017.07.004 Ohue, 2019, Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?, Cancer Sci., 110, 2080, 10.1111/cas.14069 Benavente, 2019, Contribution of IDO to human respiratory syncytial virus infection, J. Leukoc. Biol., 106, 933, 10.1002/JLB.4RU0219-051RR Ritprajak, 2019, Current paradigms of tolerogenic dendritic cells and clinical implications for systemic lupus erythematosus, Cells, 8, 1291, 10.3390/cells8101291 Zhai, 2020, Immunosuppressive IDO in cancer: mechanisms of action, animal models, and targeting strategies, Front. Immunol., 11, 1185, 10.3389/fimmu.2020.01185 Brown, 2020, Intestinal dysbiosis and tryptophan metabolism in autoimmunity, Front. Immunol., 11, 1741, 10.3389/fimmu.2020.01741 Meireson, 2020, IDO expression in cancer: different compartment, different functionality?, Front. Immunol., 11, 10.3389/fimmu.2020.531491 Jenabian, 2013, Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers, PLoS One, 8, 10.1371/journal.pone.0078146 Barnas, 2019, B cell targeted therapies in autoimmune disease, Curr. Opin. Immunol., 61, 92, 10.1016/j.coi.2019.09.004 Wekerle, 2017, B cells in multiple sclerosis, Autoimmunity, 50, 57, 10.1080/08916934.2017.1281914 Sarvaria, 2017, B cell regulation in cancer and anti-tumor immunity, Cell. Mol. Immunol., 14, 662, 10.1038/cmi.2017.35 Largeot, 2019, The B-side of cancer immunity: the underrated tune, Cells, 8, 10.3390/cells8050449 Inoue, 2018, Generation of memory B cells and their reactivation, Immunol. Rev., 283, 138, 10.1111/imr.12640 Moir, 2017, B-cell responses to HIV infection, Immunol. Rev., 275, 33, 10.1111/imr.12502 Shen, 2015, Suppressive functions of B cells in infectious diseases, Int. Immunol., 27, 513, 10.1093/intimm/dxv037 Wang, 2020, B cell development and maturation, Adv. Exp. Med. Biol., 1254, 1, 10.1007/978-981-15-3532-1_1 Liu, 2020, Regulation of humoral immune responses and B cell tolerance by the IgM fc receptor (FcμR), Adv. Exp. Med. Biol., 1254, 75, 10.1007/978-981-15-3532-1_7 Villa, 2017, Aryl hydrocarbon receptor is required for optimal B‐cell proliferation, EMBO J., 36, 116, 10.15252/embj.201695027 Rodriguez, 2013, CYP1A1 regulates breast cancer proliferation and survival, Mol. Cancer Res. MCR., 11, 780, 10.1158/1541-7786.MCR-12-0675 Vaidyanathan, 2017, The aryl hydrocarbon receptor controls cell-fate decisions in B cells, J. Exp. Med., 214, 197, 10.1084/jem.20160789 Muramatsu, 2000, Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme, Cell, 102, 553, 10.1016/S0092-8674(00)00078-7 Revy, 2000, Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2), Cell, 102, 565, 10.1016/S0092-8674(00)00079-9 Fagarasan, 2003, Intestinal IgA synthesis: regulation of front-line body defences, Nat. Rev. Immunol., 3, 63, 10.1038/nri982 Munn, 2013, Indoleamine 2.,3 dioxygenase and metabolic control of immune responses, Trends Immunol., 34, 137, 10.1016/j.it.2012.10.001 Mellor, 2017, Indoleamine 2.,3-dioxygenase and tolerance: where are we now?, Front. Immunol., 8, 10.3389/fimmu.2017.01360 Scott, 2009, The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity, J. Immunol., 182, 7509, 10.4049/jimmunol.0804328 Shinde, 2015, B cell–intrinsic IDO1 regulates humoral immunity to t cell–Independent antigens, J. Immunol., 195, 2374, 10.4049/jimmunol.1402854 Merlo, 2017, 25 Merlo, 2020, B-cell-Targeted 3DNA nanotherapy against indoleamine 2,3-dioxygenase 2 (IDO2) ameliorates autoimmune arthritis in a preclinical model, Clin. Pathol., 13, 10.1177/2632010X20951812 Merlo, 2020, Differential roles of IDO1 and IDO2 in t and B cell inflammatory immune responses, Front. Immunol., 11, 1861, 10.3389/fimmu.2020.01861 Piper, 2019, Aryl hydrocarbon receptor contributes to the transcriptional program of IL-10-producing regulatory B cells, Cell Rep., 29, 1878, 10.1016/j.celrep.2019.10.018 Jaufmann, 2019, Human monocytic myeloid‐derived suppressor cells impair B‐cell phenotype and function in vitro, Eur. J. Immunol., 16 Arneth, 2019, Impact of B cells to the pathophysiology of multiple sclerosis, J. Neuroinflammation, 16, 128, 10.1186/s12974-019-1517-1 Li, 2019, Mesenchymal stromal cells attenuate multiple sclerosis via IDO-dependent increasing the suppressive proportion of CD5+ IL-10+ B cells, Am. J. Transl. Res., 11, 5673 van Wissen, 2002, IFN-γ amplifies IL-6 and IL-8 responses by airway epithelial-like cells via indoleamine 2,3-dioxygenase, J. Immunol., 169, 7039, 10.4049/jimmunol.169.12.7039 Guillemin, 2005, Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons, Glia, 49, 15, 10.1002/glia.20090 Mehraj, 2015, Tryptophan catabolism in chronic viral infections: handling uninvited guests, Int. J. Tryptophan Res. IJTR, 8, 41 Bonezi, 2020, Flavivirus-mediating B cell differentiation into antibody-secreting cells in humans is associated with the activation of the tryptophan metabolism, Front. Immunol., 11, 20, 10.3389/fimmu.2020.00020 Morris, 2017, The role of the microbial metabolites including tryptophan catabolites and short chain fatty acids in the pathophysiology of immune-inflammatory and neuroimmune disease, Mol. Neurobiol., 54, 4432, 10.1007/s12035-016-0004-2 Gao, 2018, Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism, Front. Cell. Infect. Microbiol., 8, 13, 10.3389/fcimb.2018.00013 Sun, 2020, Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR), Crit. Rev. Food Sci. Nutr., 60, 1760, 10.1080/10408398.2019.1598334 Roager, 2018, Microbial tryptophan catabolites in health and disease, Nat. Commun., 9, 3294, 10.1038/s41467-018-05470-4 Chen, 2006, Feedback control of morphogenesis in fungi by aromatic alcohols, Genes Dev., 20, 1150, 10.1101/gad.1411806 Elleuch, 2010, Bioactive secondary metabolites from a new terrestrial Streptomyces sp. TN262, Appl. Biochem. Biotechnol., 162, 579, 10.1007/s12010-009-8808-4 Jin, 2015, The effect of tryptophol on the bacteriophage infection in high-temperature environment, Appl. Microbiol. Biotechnol., 99, 8101, 10.1007/s00253-015-6674-2 Narayanan, 1976, Beta-indoleethanol and beta-indolelactic acid production by Candida species: their antibacterial and autoantibiotic action, Antimicrob. Agents Chemother., 9, 375, 10.1128/AAC.9.3.375 Bommarius, 2013, A family of indoles regulate virulence and Shiga toxin production in pathogenic E. coli, PLoS One, 8, 10.1371/journal.pone.0054456 Holst, 2007, The physiology of glucagon-like peptide 1, Physiol. Rev., 87, 1409, 10.1152/physrev.00034.2006 de Mello, 2017, Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study, Sci. Rep., 7, 46337, 10.1038/srep46337 Zelante, 2013, Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22, Immunity, 39, 372, 10.1016/j.immuni.2013.08.003 Cervantes-Barragan, 2017, Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells, Science, 357, 806, 10.1126/science.aah5825 Cheng, 2015, Aryl hydrocarbon receptor activity of tryptophan metabolites in young adult mouse colonocytes, Drug Metab. Dispos. Biol. Fate Chem., 43, 1536, 10.1124/dmd.115.063677 Hubbard, 2015, Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles, Sci. Rep., 5, 12689, 10.1038/srep12689 Lowe, 2014, Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production, PLoS One, 9, 10.1371/journal.pone.0087877 Schiering, 2017, Feedback control of AHR signalling regulates intestinal immunity, Nature, 542, 242, 10.1038/nature21080 Rosser, 2014, Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production, Nat. Med., 20, 1334, 10.1038/nm.3680 Rosser, 2020, Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells, Cell Metab., 31, 837, 10.1016/j.cmet.2020.03.003 Platten, 2019, Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond, Nat. Rev. Drug Discov., 18, 379, 10.1038/s41573-019-0016-5 Le Naour, 2020, Trial watch: IDO inhibitors in cancer therapy, OncoImmunology, 9 Ouyang, 2020, Treating from the inside out: relevance of fecal microbiota transplantation to counteract gut damage in GVHD and HIV infection, Front. Med. (Lausanne), 7, 421, 10.3389/fmed.2020.00421 Löb, 2009, Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?, Nat. Rev. Cancer, 9, 445, 10.1038/nrc2639 Ramadoss, 2004, Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells, Mol. Pharmacol., 66, 129, 10.1124/mol.66.1.129 Blasco, 2020, The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism, Sci. Rep., 10, 16824, 10.1038/s41598-020-73966-5 Bouças, 2020, Why severe COVID-19 patients are at greater risk of developing depression: a molecular perspective, Neuroscientist Cai, 2020, Kynurenic acid underlies sex-specific immune responses to COVID-19, Infect. Dis. (except HIV/AIDS) Essa, 2020, Possible role of tryptophan and melatonin in COVID-19, Int. J. Tryptophan Res., 13, 10.1177/1178646920951832 Turski, 2020, AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives, Restor. Neurol. Neurosci., 38, 343 Kimhofer, 2020, Integrative modeling of quantitative plasma lipoprotein, metabolic, and amino acid data reveals a multiorgan pathological signature of SARS-CoV-2 infection, J. Proteome Res., 19, 4442, 10.1021/acs.jproteome.0c00519 Thomas, 2020, COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status, Infect. Dis. (except HIV/AIDS) Belladonna, 2020, Potential benefits of tryptophan metabolism to the efficacy of Tocilizumab in COVID-19, Front. Pharmacol., 11, 959, 10.3389/fphar.2020.00959