Lateral bone augmentation with newly developed β‐tricalcium phosphate block: an experimental study in the rabbit mandible

Clinical Oral Implants Research - Tập 22 Số 12 - Trang 1366-1371 - 2011
Daisuke Ono1, Ryo Jimbo2,3, Giichiro Kawachi4, Koji Ioku5, Tohru Ikeda6, Takashi Sawase1
1Division of Applied Prosthodontics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
2Department of Biomaterials/Handicap Research, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
3Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
4Department of Biomaterials, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
5Department of Environmental Studies, Graduate School of Environmental Studies, Tohoku University, Sendai, Japan
6Division of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Tóm tắt

AbstractObjective: To evaluate the biological effects of newly developed β‐tricalcium phosphate (β‐TCP) to improve lateral bone augmentation.Material and methods: Test samples (rod‐shaped [RS]‐blocks) were prepared through hydrothermal processing α‐TCPs. As controls, commercially available β‐TCPs (C‐blocks; Osferion) were used. The blocks were placed onto the rabbit mandibles (n=5/group, mean: 4 kg). Samples were retrieved after 6, 12 and 24 weeks. Thereafter, the sections were evaluated for histological and histomorphometric analyses. The parameters set were: BV/TV (%): [(area of newly formed bone; area‐NFB)/(whole measured area; WA)] × 100, BV+Imp.V/TV (%): [(area‐NFB+area of remaining β‐TCP block)/WA] × 100, N.Oc/I.Pm: (osteoclast number)/(entire β‐TCP block perimeter; 100 mm).Results: BV/TV of the C‐blocks (10.71±3.39%) was significantly higher than the RS‐blocks (3.5±3.52%, P<0.05) at 6 weeks. At 24 weeks, the RS‐blocks (23.66±2.7%) showed significantly higher values than the C‐blocks (13.23±2.65%, P<0.001). The BV+Imp.V/TV of the RS‐blocks was significantly higher than that of the C‐block group (29.61±5.84% and 19.13±3.14%), maintaining high values between 6 and 24 weeks (44.16±5.19% and 50.88±4%, P<0.001). The N.Oc/I.Pm values were significantly greater in the RS‐block group than in the C‐block group throughout the observation period (P<0.05).Conclusions: The newly developed β‐TCP blocks presented subsequent replacement by newly formed bone, in conjunction with maintaining the external morphology.To cite this article: Ono D, Jimbo R, Kawachi G, Ioku K, Ikeda T, Sawase T. Lateral bone augmentation with newly developed β‐tricalcium phosphate block: an experimental study in the rabbit mandible.
Clin. Oral Impl. Resxx, 2011; 000–000.

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Clinical Oral Implants Research

Tập 22 Số 12

1366-1371

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