Language impairment in Huntington's disease

Arquivos de Neuro-Psiquiatria - Tập 70 Số 6 - Trang 410-415 - 2012
Mariana Jardim Azambuja1, Márcia Radanovic2, Mônica Santoro Haddad3,4, Carla Cristina Adda5,6,7, Egberto Reis Barbosa8, Letı́cia Lessa Mansur8
1Department of Neurology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil
2MD, MSc, PhD, Department of Neurology, University of São Paulo School of Medicine, São Paulo SP, Brazil;
3MD, MSc, Department of Neurology, University of São Paulo School of Medicine, São Paulo SP, Brazil;
4MSc, Psychology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo SP, Brazil;
5Boston para Diagnóstico da Afasia, de Nomeação de Boston, Token,
6Movement Disorders Unit, Neurology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo SP, Brazil.
7º andar; 05403-000 São Paulo SP -Brasil;
8University of São Paulo, Brazil

Tóm tắt

Language alterations in Huntington's disease (HD) are reported, but their nature and correlation with other cognitive impairments are still under investigation. This study aimed to characterize the language disturbances in HD and to correlate them to motor and cognitive aspects of the disease. We studied 23 HD patients and 23 controls, matched for age and schooling, using the Boston Diagnostic Aphasia Examination, Boston Naming Test, the Token Test, Animal fluency, Action fluency, FAS-COWA, the Symbol Digit Modalities Test, the Stroop Test and the Hooper Visual Organization Test (HVOT). HD patients performed poorer in verbal fluency (p<0.0001), oral comprehension (p<0.0001), repetition (p<0.0001), oral agility (p<0.0001), reading comprehension (p=0.034) and narrative writing (p<0.0001). There was a moderate correlation between the Expressive Component and Language Competency Indexes and the HVOT (r=0.519, p=0.011 and r=0.450, p=0.031, respectively). Language alterations in HD seem to reflect a derangement in both frontostriatal and frontotemporal regions.

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Arquivos de Neuro-Psiquiatria

Tập 70 Số 6

410-415

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