Laminin/β1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization
Tóm tắt
Từ khóa
Tài liệu tham khảo
Arimura N, Kaibuchi K . Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci 2007; 8:194–205.
Barnes AP, Polleux F . Establishment of axon-dendrite polarity in developing neurons. Annu Rev Neurosci 2009; 32:347–381.
Witte H, Neukirchen D, Bradke F . Microtubule stabilization specifies initial neuronal polarization. J Cell Biol 2008; 180:619–632.
Bradke F, Dotti CG . The role of local actin instability in axon formation. Science 1999; 283:1931–1934.
Schwamborn JC, Püschel AW . The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat Neurosci 2004; 7:923–929.
Hirai S, Banba Y, Satake T, Ohno S . Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-jun n-terminal kinase pathway. J Neurosci 2011; 31:6468–6480.
Sengottuvel V, Leibinger M, Pfreimer M, Andreadaki A, Fischer D . Taxol facilitates axon regeneration in the mature CNS. J Neurosci 2011; 31:2688–2699.
Barnes AP, Solecki D, Polleux F . New insights into the molecular mechanisms specifying neuronal polarity in vivo. Curr Opin Neurobiol 2008; 18:44–52.
Bradke F, Dotti CG . Establishment of neuronal polarity: lessons from cultured hippocampal neurons. Curr Opin Neurobiol 2000; 10:574–581.
Dotti CG, Sullivan CA, Banker GA . The establishment of polarity by hippocampal neurons in culture. J Neurosci 1988; 8:1454–1468.
Barnes AP, Lilley BN, Pan YA, et al. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 2007; 129:549–563.
Kishi M, Pan YA, Crump JG, Sanes JR . Mammalian SAD kinases are required for neuronal polarization. Science 2005; 307:929–932.
Shelly M, Cancedda L, Heilshorn S, Sumbre G, Poo MM . LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 2007; 129:565–577.
Yi JJ, Barnes AP, Hand R, Polleux F, Ehlers MD . TGF-beta signaling specifies axons during brain development. Cell 2010; 142:144–157.
Randlett O, Poggi L, Zolessi FR, Harris WA . The oriented emergence of axons from retinal ganglion cells is directed by laminin contact in vivo. Neuron 2011; 70:266–280.
Dertinger SK, Jiang X, Li Z, Murthy VN, Whitesides GM . Gradients of substrate-bound laminin orient axonal specification of neurons. Proc Natl Acad Sci USA 2002; 99:12542–12547.
Esch T, Lemmon V, Banker G . Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons. J Neurosci 1999; 19:6417–6426.
Lathia JD, Patton B, Eckley DM, et al. Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol 2007; 505:630–643.
Gupton SL, Gertler FB . Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell 2010; 18:725–736.
Tan CL, Kwok JC, Patani R, Ffrench-Constant C, Chandran S, Fawcett JW, . Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling. J Neurosci 2011; 31:6289–6295.
Robles E, Gomez TM . Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding. Nat Neurosci 2006; 9:1274–1283.
Graus-Porta D, Blaess S, Senften M, et al. beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 2001; 31:367–379.
Belvindrah R, Graus-Porta D, Goebbels S, Nave KA, Müller U . beta 1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 2007; 27:13854–13865.
Belvindrah R, Hankel S, Walker J, Patton BL, Müller U . beta 1 integrins control the formation of cell chains in the adult rostral migratory stream. J Neurosci 2007; 27:2704–2717.
Huang Z, Shimazu K, Woo NH, et al. Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci 2006; 26:11208–11219.
Luque A, Gómez M, Puzon W, Takada Y, Sánchez-Madrid F, Carlos Cabañas . Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain. J Biol Chem 1996; 271:11067–11075.
Adams JC, Watt FM . Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface. Cell 1990; 63:425–435.
Carroll JM, Romero MR, Watt FM . Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell 1995; 83:957–968.
Noto K, Kato K, Okumura K, Yagita H . Identification and functional characterization of mouse CD29 with a mAb. Int Immunol 1995; 7:835–842.
Bazzoni G, Shih DT, Buck CA, Hemler ME . Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem 1995; 270:25570–25577.
Polleux F, Giger RJ, Ginty DD, Kolodkin AL, Ghosh A . Patterning of cortical efferent projections by semaphorin-neuropilin interactions. Science 1998; 282:1904–1906.
Jiang X, Xu Q, Dertinger SK, Stroock AD, Fu TM, Whitesides GM . A general method for patterning gradients of biomolecules on surfaces using microfluidic networks. Anal Chem 2005; 77:2338–2347.
Mai J, Fok L, Gao H, Zhang X, Poo MM . Axon initiation and growth cone turning on bound protein gradients. J Neurosci 2009; 29:7450–7458.
Almeida EA, Huovila AP, Sutherland AE, et al. Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Cell 1995; 81:1095–1104.
Fässler R, Meyer M . Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 1995; 9:1896–1908.
Raghavan S, Bauer C, Mundschau G, Li Q, Fuchs E . Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol 2000; 150:1149–1160.
Gorski JA, Talley T, Qiu M, Puelles L, Rubenstein JL, Jones KR . Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 2002; 22:6309–6314.
Molnar Z, Adams R, Blakemore C . Mechanisms underlying the early establishment of thalamocortical connections in the rat. J Neurosci 1998; 18:5723–5745.
Kawano H, Fukuda T, Kubo K, et al. Pax-6 is required for thalamocortical pathway formation in fetal rats. J Comp Neurol 1999; 408:147–160.
Fujimori KE, Takeuchi K, Yazaki T, Uyemura K, Nojyo Y, Tamamki N . Expression of L1 and TAG-1 in the corticospinal, callosal, and hippocampal commissural neurons in the developing rat telencephalon as revealed by retrograde and in situ hybridization double labeling. J Comp Neurol 2000; 417:275–288.
Denaxa M, Chan CH, Schachner M, Parnavelas JG, Karagogeos D . The adhesion molecule TAG-1 mediates the migration of cortical interneurons from the ganglionic eminence along the corticofugal fiber system. Development 2001; 128:4635–4644.
Espinosa A, Gil-Sanz C, Yanagawa Y, Fairen A . Two separate subtypes of early non-subplate projection neurons in the developing cerebral cortex of rodents. Front Neuroanat 2009; 3:27.
Felsenfeld DP, Hynes MA, Skoler KM, Furley AJ, Jessell TM . TAG-1 can mediate homophilic binding, but neurite outgrowth on TAG-1 requires an L1-like molecule and beta 1 integrins. Neuron 1994; 12:675–690.
Förster E, Tielsch A, Saum B, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proc Natl Acad Sci USA 2002; 99:13178–13183.
Radakovits R, Barros CS, Belvindrah R, Patton B, Müller U . Regulation of radial glial survival by signals from the meninges. J Neurosci 2009; 29:7694–7705.
Saito T, Nakatsuji N . Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev Biol 2001; 240:237–246.
Loulier K, Lathia JD, Marthiens V, et al. beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol 2009; 7:e1000176.
Guo W, Jiang H, Gray V, Dedhar S, Rao Y . Role of the integrin-linked kinase (ILK) in determining neuronal polarity. Dev Biol 2007; 306:457–468.
Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S . Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 1998; 95:11211–11216.
Westermann S, Weber K . Post-translational modifications regulate microtubule function. Nat Rev Mol Cell Biol 2003; 4:938–947.
Stepanova T, Slemmer J, Hoogenraad CC, et al. Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein). J Neurosci 2003; 23:2655–2664.
Cappello S, Attardo A, Wu X, et al. The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 2006; 9:1099–1107.
Chen YM, Wang QJ, Hu HS, et al. Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc Natl Acad Sci USA 2006; 103:8534–8539.
Costa MR, Wen G, Lepier A, Schroeder T, Götz M . Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex. Development 2008; 135:11–22.
Shi SH, Jan LY, Jan YN . Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI3-kinase activity. Cell 2003; 112:63–75.
Zhang X, Zhu J, Yang GY, et al. Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat Cell Biol 2007; 9:743–754.
Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, Gundersen GG . Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science 2004; 303:836–839.
Lim CJ, Han J, Yousefi N, et al. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol 2007; 9:415–421.
Toyoshima F, Nishida E . Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner. EMBO J 2007; 26:1487–1498.
Reverte CG, Benware A, Jones CW, LaFlamme SE . Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis. J Cell Biol 2006; 174:491–497.
Adler CE, Fetter RD, Bargmann CI . UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation. Nat Neurosci 2006; 9:511–518.
Lerman O, Ben-Zvi A, Yagil Z, Behar O . Semaphorin3A accelerates neuronal polarity in vitro and in its absence the orientation of DRG neuronal polarity in vivo is distorted. Mol Cell Neurosci 2007; 36:222–234.
Staquicini FI, Dias-Neto E, Li J, et al. Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Proc Natl Acad Sci USA 2009; 106:2903–2908.
Hagedorn EJ, Yashiro H, Ziel JW, Ihara S, Wang Z, Sherwood DR, . Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. Dev Cell 2009; 17:187–198.
Stanco A, Szekeres C, Patel N, et al. Netrin-1-alpha3beta1 integrin interactions regulate the migration of interneurons through the cortical marginal zone. Proc Natl Acad Sci USA 2009; 106:7595–7600.
Yebra M, Montgomery AM, Diaferia GR, et al. Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell 2003; 5:695–707.
Höpker VH, Shewan D, Tessier-Lavigne M, Poo M, Holt C . Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature 1999; 401:69–73.
Nakamoto T, Kain KH, Ginsberg MH . Neurobiology: new connections between integrins and axon guidance. Curr Biol 2004; 14:R121–123.
Stevens A, Jacobs JR . Integrins regulate responsiveness to slit repellent signals. J Neurosci 2002; 22:4448–4455.
Li N, Hsu CH, Folch A . Parallel mixing of photolithographically defined nanoliter volumes using elastomeric microvalve arrays. Electrophoresis 2005; 26:3758–3764.
De Simoni A, Yu LM . Preparation of organotypic hippocampal slice cultures: interface method. Nat Protoc 2006; 1:1439–1445.