Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer’s Disease Patients
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Desforges, 2019, Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System, Viruses, 12, 14, 10.3390/v12010014
Asadi-Pooya, 2020, Central Nervous System Manifestations of COVID-19: A Systematic Review, J Neurol Sci, 413, 10.1016/j.jns.2020.116832
Mao, 2020, Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China, JAMA Neurol, 77, 10.1001/jamaneurol.2020.1127
Verity, 2020, Estimates of the Severity of Coronavirus Disease 2019: A Model-Based Analysis, Lancet Infect Dis, 20, 10.1016/s1473-3099(20)30243-7
Zhou, 2020, Clinical Course and Risk Factors for Mortality of Adult Inpatients With COVID-19 in Wuhan, China: A Retrospective Cohort Study, Lancet, 395, 10.1016/s0140-6736(20)30566-3
Aggarwal, 2020, Cerebrovascular Disease is Associated With an Increased Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19): A Pooled Analysis of Published Literature, Int J Stroke, 15, 10.1177/1747493020921664
Atkins, 2020, Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort, J Gerontol A Biol Sci Med Sci, 75, 10.1093/gerona/glaa183
Wang, 2021, COVID-19 and Dementia: Analyses of Risk, Disparity, and Outcomes From Electronic Health Records in the US, Alzheimers Dement, 17, 10.1002/alz.12296
Mok, 2020, Tackling Challenges in Care of Alzheimer’s Disease and Other Dementias Amid the COVID-19 Pandemic, Now and in the Future, Alzheimers Dement, 16, 10.1002/alz.12143
Beigel, 2020, Remdesivir for the Treatment of Covid-19 - Final Report, N Engl J Med, 383, 10.1056/NEJMoa2007764
Mirabelli, 2021, Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19, Proc Natl Acad Sci U.S.A., 118, e2105815118, 10.1073/pnas.2105815118
Campione, 2021, Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences, Front Pharmacol, 12, 10.3389/fphar.2021.666600
Rosa, 2021, Ambulatory COVID-19 Patients Treated With Lactoferrin as a Supplementary Antiviral Agent: A Preliminary Study, J Clin Med, 10, 4276, 10.3390/jcm10184276
Campione, 2021, Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence, Int J Environ Res Public Health, 18, 10985, 10.3390/ijerph182010985
Miotto, 2021, Molecular Mechanisms Behind Anti SARS-CoV-2 Action of Lactoferrin, Front Mol Biosci, 8, 10.3389/fmolb.2021.607443
Carro, 2017, Early Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease Based on Salivary Lactoferrin, Alzheimers Dement (Amst), 8, 10.1016/j.dadm.2017.04.002
González-Sánchez, 2020, Decreased Salivary Lactoferrin Levels are Specific to Alzheimer’s Disease, EBioMedicine, 57, 10.1016/j.ebiom.2020.102834
Numbers, 2021, The Effects of the COVID-19 Pandemic on People With Dementia, Nat Rev Neurol, 17, 69, 10.1038/s41582-020-00450-z
Williamson, 2020, Factors Associated With COVID-19-Related Death Using OpenSAFELY, Nature, 584, 10.1038/s41586-020-2521-4
Rahman, 2021, Neurobiochemical Cross-Talk Between COVID-19 and Alzheimer’s Disease, Mol Neurobiol, 58, 10.1007/s12035-020-02177-w
Sweeney, 2018, Blood-Brain Barrier Breakdown in Alzheimer Disease and Other Neurodegenerative Disorders, Nat Rev Neurol, 14, 10.1038/nrneurol.2017.188
Nation, 2019, Blood-Brain Barrier Breakdown Is an Early Biomarker of Human Cognitive Dysfunction, Nat Med, 25, 10.1038/s41591-018-0297-y
De Chiara, 2012, Infectious Agents and Neurodegeneration, Mol Neurobiol, 46, 10.1007/s12035-012-8320-7
Kuo, 2020, APOE E4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort, J Gerontol A Biol Sci Med Sci, 75, 10.1093/gerona/glaa131
Ashraf, 2019, The Possibility of an Infectious Etiology of Alzheimer Disease, Mol Neurobiol, 56, 10.1007/s12035-018-1388-y
Patrick, 2019, Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat, Front Cell Infect Microbiol, 9, 10.3389/fcimb.2019.00138
Fulop, 2018, Role of Microbes in the Development of Alzheimer’s Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco, Front Genet, 9, 10.3389/fgene.2018.00362
Readhead, 2018, Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus, Neuron, 99, 64, 10.1016/j.neuron.2018.05.023
Sochocka, 2017, The Infectious Etiology of Alzheimer’s Disease, Curr Neuropharmacol, 15, 996, 10.2174/1570159x15666170313122937
Lim, 2015, Infection, Systemic Inflammation, and Alzheimer’s Disease, Microbes Infect, 17, 10.1016/j.micinf.2015.04.004
Roubaud Baudron, 2015, Alzheimer’s Disease: The Infectious Hypothesis, Geriatr Psychol Neuropsychiatr Vieil, 13, 10.1684/pnv.2015.0574
Rosa, 2017, Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis, Int J Mol Sci, 18, 1985, 10.3390/ijms18091985
Gerlach, 1994, Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases, J Neurochem, 63, 793, 10.1046/j.1471-4159.1994.63030793.x
Du, 2018, Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates With Decreased Cognitive Function in Alzheimer’s Disease, ACS Chem Neurosci, 9, 10.1021/acschemneuro.8b00194
Cunningham, 2005, Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death During Chronic Neurodegeneration, J Neurosci, 25, 10.1523/jneurosci.2614-05.2005
Dal Prà, 2015, Do Astrocytes Collaborate With Neurons in Spreading the "Infectious" Aβ and Tau Drivers of Alzheimer’s Disease, Neuroscientist, 21, 9, 10.1177/1073858414529828
Liu, 2018, Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications, Front Neurosci, 12, 10.3389/fnins.2018.00632
Paesano, 2012, Body Iron Delocalization: The Serious Drawback in Iron Disorders in Both Developing and Developed Countries, Pathog Glob Health, 106, 10.1179/2047773212y.0000000043
2017, Global, Regional, and National Incidence, Prevalence, and Years Lived With Disability for 328 Diseases and Injuries for 195 Countries, 1990-2016: A Systematic Analysis for the Global Burden of Disease Study 2016, Lancet, 390, 10.1016/s0140-6736(17)32154-2
Sienkiewicz, 2021, Lactoferrin: An Overview of its Main Functions, Immunomodulatory and Antimicrobial Role, and Clinical Significance, Crit Rev Food Sci Nutr, 1, 10.1080/10408398.2021.1895063
McQuaid, 2021, SARS-CoV-2: Is There Neuroinvasion, Fluids Barriers CNS, 18, 32, 10.1186/s12987-021-00267-y
Sundar, 2020, An Agent-Based Model to Investigate Microbial Initiation of Alzheimer’s via the Olfactory System, Theor Biol Med Model, 17, 5, 10.1186/s12976-020-00123-w
Burks, 2021, Can SARS-CoV-2 Infect the Central Nervous System via the Olfactory Bulb or the Blood-Brain Barrier, Brain Behav Immun, 95, 7, 10.1016/j.bbi.2020.12.031
Ding, 2021, Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains With Alzheimer’s Disease, Int J Mol Sci, 22, 1687, 10.3390/ijms22041687
Sulzer, 2020, COVID-19 and Possible Links With Parkinson’s Disease and Parkinsonism: From Bench to Bedside, NPJ Parkinsons Dis, 6, 18, 10.1038/s41531-020-00123-0
Xu, 2022, Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus, Cell Mol Neurobiol, 42, 10.1007/s10571-020-00915-1
Hsu, 2021, The Effects of Aβ(1-42) Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2, Int J Mol Sci, 22, 8226, 10.3390/ijms22158226
Iadecola, 2020, Effects of COVID-19 on the Nervous System, Cell, 183, 16, 10.1016/j.cell.2020.08.028
Kumar, 2021, Disease-Drug and Drug-Drug Interaction in COVID-19: Risk and Assessment, BioMed Pharmacother, 139, 10.1016/j.biopha.2021.111642
Bermejo-Pareja, 2020, Salivary Lactoferrin as Biomarker for Alzheimer’s Disease: Brain-Immunity Interactions, Alzheimers Dement, 16, 10.1002/alz.12107
Morales, 2014, Neuroinflammation in the Pathogenesis of Alzheimer’s Disease. A Rational Framework for the Search of Novel Therapeutic Approaches, Front Cell Neurosci, 8, 10.3389/fncel.2014.00112
Heneka, 2015, Neuroinflammation in Alzheimer’s Disease, Lancet Neurol, 14, 388, 10.1016/s1474-4422(15)70016-5
Sternberg, 2006, Neural Regulation of Innate Immunity: A Coordinated Nonspecific Host Response to Pathogens, Nat Rev Immunol, 6, 10.1038/nri1810
Wrona, 2006, Neural-Immune Interactions: An Integrative View of the Bidirectional Relationship Between the Brain and Immune Systems, J Neuroimmunol, 172, 38, 10.1016/j.jneuroim.2005.10.017
Besedovsky, 2019, The Immune System as a Sensorial System That can Modulate Brain Functions and Reset Homeostasis, Ann N Y Acad Sci, 1437, 5, 10.1111/nyas.13935
Kraneveld, 2014, The Neuro-Immune Axis: Prospect for Novel Treatments for Mental Disorders, Basic Clin Pharmacol Toxicol, 114, 10.1111/bcpt.12154
Lampron, 2013, Innate Immunity in the CNS: Redefining the Relationship Between the CNS and Its Environment, Neuron, 78, 10.1016/j.neuron.2013.04.005
Gao, 2008, Why Neurodegenerative Diseases are Progressive: Uncontrolled Inflammation Drives Disease Progression, Trends Immunol, 29, 10.1016/j.it.2008.05.002
Balistreri, 2013, NF-κb Pathway Activators as Potential Ageing Biomarkers: Targets for New Therapeutic Strategies, Immun Ageing, 10, 24, 10.1186/1742-4933-10-24
Shi, 2018, Interplay Between Innate Immunity and Alzheimer Disease: APOE and TREM2 in the Spotlight, Nat Rev Immunol, 18, 10.1038/s41577-018-0051-1
Le Page, 2018, Role of the Peripheral Innate Immune System in the Development of Alzheimer’s Disease, Exp Gerontol, 107, 59, 10.1016/j.exger.2017.12.019
Abbott, 2020, Are Infections Seeding Some Cases of Alzheimer’s Disease, Nature, 587, 10.1038/d41586-020-03084-9
Hur, 2020, The Innate Immunity Protein IFITM3 Modulates γ-Secretase in Alzheimer’s Disease, Nature, 586, 10.1038/s41586-020-2681-2
Kinney, 2018, Inflammation as a Central Mechanism in Alzheimer’s Disease, Alzheimers Dement (N Y), 4, 10.1016/j.trci.2018.06.014
Meade, 2018, β-Defensins: Farming the Microbiome for Homeostasis and Health, Front Immunol, 9, 10.3389/fimmu.2018.03072
Vila, 2019, The Power of Saliva: Antimicrobial and Beyond, PloS Pathog, 15, 10.1371/journal.ppat.1008058
Lupetti, 2003, Radiolabelled Antimicrobial Peptides for Infection Detection, Lancet Infect Dis, 3, 10.1016/S1473-3099(03)00579-6
Williams, 2012, Do β-Defensins and Other Antimicrobial Peptides Play a Role in Neuroimmune Function and Neurodegeneration, ScientificWorldJournal, 2012, 10.1100/2012/905785
Ramagopalan, 2010, Vitamin D-Dependent Rickets, HLA-DRB1, and the Risk of Multiple Sclerosis, Arch Neurol, 67, 10.1001/archneurol.2010.182
Bevins, 2011, Paneth Cells, Antimicrobial Peptides and Maintenance of Intestinal Homeostasis, Nat Rev Microbiol, 9, 10.1038/nrmicro2546
Wiesner, 2010, Antimicrobial Peptides: The Ancient Arm of the Human Immune System, Virulence, 1, 10.4161/viru.1.5.12983
Mansour, 2014, Host Defense Peptides: Front-Line Immunomodulators, Trends Immunol, 35, 10.1016/j.it.2014.07.004
Moir, 2018, The Antimicrobial Protection Hypothesis of Alzheimer’s Disease, Alzheimers Dement, 14, 10.1016/j.jalz.2018.06.3040
Welling, 2015, Potential Role of Antimicrobial Peptides in the Early Onset of Alzheimer’s Disease, Alzheimers Dement, 11, 10.1016/j.jalz.2013.12.020
Iqbal, 2020, The Use of Antimicrobial and Antiviral Drugs in Alzheimer’s Disease, Int J Mol Sci, 21, 4920, 10.3390/ijms21144920
Pfaffe, 2011, Diagnostic Potential of Saliva: Current State and Future Applications, Clin Chem, 57, 10.1373/clinchem.2010.153767
Fábián, 2008, Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and Their Use in the Early Diagnosis of Cancer and Other Diseases, Curr Genomics, 9, 11, 10.2174/138920208783884900
Gautam, 2004, Cholinergic Stimulation of Salivary Secretion Studied With M1 and M3 Muscarinic Receptor Single- and Double-Knockout Mice, Mol Pharmacol, 66, 10.1124/mol.66.2.260
Nakamura, 2004, M(3) Muscarinic Acetylcholine Receptor Plays a Critical Role in Parasympathetic Control of Salivation in Mice, J Physiol, 558, 10.1113/jphysiol.2004.064626
Proctor, 2014, Salivary Secretion: Mechanism and Neural Regulation, Monogr Oral Sci, 24, 14, 10.1159/000358781
Proctor, 2021, Disease-Induced Changes in Salivary Gland Function and the Composition of Saliva, J Dent Res, 100, 10.1177/00220345211004842
Pavlov, 2018, Molecular and Functional Neuroscience in Immunity, Annu Rev Immunol, 36, 783, 10.1146/annurev-immunol-042617-053158
Antequera, 2021, Salivary Lactoferrin Expression in a Mouse Model of Alzheimer’s Disease, Front Immunol, 12, 10.3389/fimmu.2021.749468
Valenti, 2005, Lactoferrin: An Important Host Defence Against Microbial and Viral Attack, Cell Mol Life Sci, 62, 10.1007/s00018-005-5372-0
Berlutti, 2011, Antiviral Properties of Lactoferrin–a Natural Immunity Molecule, Molecules, 16, 6992, 10.3390/molecules16086992
Oda, 2021, Antiviral Effects of Bovine Lactoferrin on Human Norovirus, Biochem Cell Biol, 99, 10.1139/bcb-2020-0035
Kruzel, 2017, Lactoferrin in a Context of Inflammation-Induced Pathology, Front Immunol, 8, 10.3389/fimmu.2017.01438
Legrand, 2012, Lactoferrin, a Key Molecule in Immune and Inflammatory Processes, Biochem Cell Biol, 90, 10.1139/o11-056
Legrand, 2005, Lactoferrin: A Modulator of Immune and Inflammatory Responses, Cell Mol Life Sci, 62, 10.1007/s00018-005-5370-2
García-Montoya, 2012, Lactoferrin a Multiple Bioactive Protein: An Overview, Biochim Biophys Acta, 1820, 10.1016/j.bbagen.2011.06.018
Ferreira, 2015, Lactoferrin Levels in Gingival Crevicular Fluid and Saliva of HIV-Infected Patients With Chronic Periodontitis, J Investig Clin Dent, 6, 16, 10.1111/jicd.12017
Berlutti, 2011, Lactoferrin and Oral Diseases: Current Status and Perspective in Periodontitis, Ann Stomatol (Roma), 2
Mizuhashi, 2015, Levels of the Antimicrobial Proteins Lactoferrin and Chromogranin in the Saliva of Individuals With Oral Dryness, J Prosthet Dent, 113, 10.1016/j.prosdent.2013.12.028
Kobus, 2017, Unstimulated Salivary Flow, Ph, Proteins and Oral Health in Patients With Juvenile Idiopathic Arthritis, BMC Oral Health, 17, 94, 10.1186/s12903-017-0386-1
Wakabayashi, 2010, Periodontitis, Periodontopathic Bacteria and Lactoferrin, Biometals, 23, 10.1007/s10534-010-9304-6
Chorzewski, 2017, Salivary Protective Factors in Patients Suffering From Decompensated Type 2 Diabetes, Adv Med Sci, 62, 10.1016/j.advms.2016.06.005
Rosa, 2021, Lactoferrin and Oral Pathologies: A Therapeutic Treatment, Biochem Cell Biol, 99, 81, 10.1139/bcb-2020-0052
Reseco, 2021, Salivary Lactoferrin Is Associated With Cortical Amyloid-Beta Load, Cortical Integrity, and Memory in Aging, Alzheimers Res Ther, 13, 150, 10.1186/s13195-021-00891-8
Lynge Pedersen, 2019, The Role of Natural Salivary Defences in Maintaining a Healthy Oral Microbiota, J Dent, S3, 10.1016/j.jdent.2018.08.010
Olsen, 2021, Low Levels of Salivary Lactoferrin may Affect Oral Dysbiosis and Contribute to Alzheimer’s Disease: A Hypothesis, Med Hypotheses, 146, 10.1016/j.mehy.2020.110393
de Lillo, 1996, Binding and Degradation of Lactoferrin by Porphyromonas Gingivalis, Prevotella Intermedia and Prevotella Nigrescens, FEMS Immunol Med Microbiol, 14, 10.1111/j.1574-695X.1996.tb00280.x
Alugupalli, 1996, Degradation of Lactoferrin by Periodontitis-Associated Bacteria, FEMS Microbiol Lett, 145, 10.1111/j.1574-6968.1996.tb08579.x
Hayashi, 2017, Salivary Lactoferrin is Transferred Into the Brain via the Sublingual Route, Biosci Biotechnol Biochem, 81, 10.1080/09168451.2017.1308241
Huang, 2007, Characterization of Lactoferrin Receptor in Brain Endothelial Capillary Cells and Mouse Brain, J BioMed Sci, 14, 10.1007/s11373-006-9121-7
Kawamata, 1993, Lactotransferrin Immunocytochemistry in Alzheimer and Normal Human Brain, Am J Pathol, 142
Agrawal, 2018, Recent Advancements in the Field of Nanotechnology for the Delivery of Anti-Alzheimer Drug in the Brain Region, Expert Opin Drug Delivery, 15, 589, 10.1080/17425247.2018.1471058
Meng, 2018, Intranasal Delivery of Huperzine A to the Brain Using Lactoferrin-Conjugated N-Trimethylated Chitosan Surface-Modified PLGA Nanoparticles for Treatment of Alzheimer’s Disease, Int J Nanomedicine, 13, 10.2147/ijn.S151474
Crapper McLachlan, 1991, Intramuscular Desferrioxamine in Patients With Alzheimer’s Disease, Lancet, 337, 10.1016/0140-6736(91)92978-b
Guo, 2013, Deferoxamine Inhibits Iron Induced Hippocampal Tau Phosphorylation in the Alzheimer Transgenic Mouse Brain, Neurochem Int, 62, 10.1016/j.neuint.2012.12.005
Guo, 2013, Intranasal Deferoxamine Reverses Iron-Induced Memory Deficits and Inhibits Amyloidogenic APP Processing in a Transgenic Mouse Model of Alzheimer’s Disease, Neurobiol Aging, 34, 10.1016/j.neurobiolaging.2012.05.009
Cuajungco, 2000, Metal Chelation as a Potential Therapy for Alzheimer’s Disease, Ann NY Acad Sci, 920, 292, 10.1111/j.1749-6632.2000.tb06938.x
Lepanto, 2019, Lactoferrin in Aseptic and Septic Inflammation, Molecules, 24, 1323, 10.3390/molecules24071323
Paesano, 2010, Lactoferrin Efficacy Versus Ferrous Sulfate in Curing Iron Disorders in Pregnant and Non-Pregnant Women, Int J Immunopathol Pharmacol, 23, 10.1177/039463201002300220
Paesano, 2014, Safety and Efficacy of Lactoferrin Versus Ferrous Sulphate in Curing Iron Deficiency and Iron Deficiency Anaemia in Hereditary Thrombophilia Pregnant Women: An Interventional Study, Biometals, 27, 999, 10.1007/s10534-014-9723-x
Paesano, 2006, Oral Administration of Lactoferrin Increases Hemoglobin and Total Serum Iron in Pregnant Women, Biochem Cell Biol, 84, 10.1139/o06-040
Lepanto, 2018, Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-Pregnant Women: An Interventional Study, Front Immunol, 9, 10.3389/fimmu.2018.02123
Cutone, 2014, Lactoferrin Prevents LPS-Induced Decrease of the Iron Exporter Ferroportin in Human Monocytes/Macrophages, Biometals, 27, 10.1007/s10534-014-9742-7
Cutone, 2017, Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages, Front Immunol, 8, 10.3389/fimmu.2017.00705
Guo, 2017, Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer’s Disease Mouse Model, Neuropsychopharmacology, 42, 10.1038/npp.2017.8
Mohamed, 2019, A Pilot Study on the Effect of Lactoferrin on Alzheimer’s Disease Pathological Sequelae: Impact of the P-Akt/PTEN Pathway, BioMed Pharmacother, 111, 10.1016/j.biopha.2018.12.118
Abdelhamid, 2020, Dietary Lactoferrin Supplementation Prevents Memory Impairment and Reduces Amyloid-β Generation in J20 Mice, J Alzheimers Dis, 74, 10.3233/jad-191181
Bonam, 2020, Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients, Cell Rep Med, 1, 10.1016/j.xcrm.2020.100016
Hu, 2021, The In Vitro Antiviral Activity of Lactoferrin Against Common Human Coronaviruses and SARS-CoV-2 Is Mediated by Targeting the Heparan Sulfate Co-Receptor, Emerg Microbes Infect, 10, 10.1080/22221751.2021.1888660
Salaris, 2021, Protective Effects of Lactoferrin Against SARS-CoV-2 Infection In Vitro, Nutrients, 13, 328, 10.3390/nu13020328
Mehta, 2020, COVID-19: Consider Cytokine Storm Syndromes and Immunosuppression, Lancet, 395, 10.1016/s0140-6736(20)30628-0
Togawa, 2002, Oral Administration of Lactoferrin Reduces Colitis in Rats via Modulation of the Immune System and Correction of Cytokine Imbalance, J Gastroenterol Hepatol, 17, 10.1046/j.1440-1746.2002.02868.x
Zimecki, 1998, Lactoferrin Lowers Serum Interleukin 6 and Tumor Necrosis Factor Alpha Levels in Mice Subjected to Surgery, Arch Immunol Ther Exp (Warsz), 46, 97
Cutone, 2019, Aerosolized Bovine Lactoferrin Counteracts Infection, Inflammation and Iron Dysbalance in A Cystic Fibrosis Mouse Model of Pseudomonas Aeruginosa Chronic Lung Infection, Int J Mol Sci, 20, 2128, 10.3390/ijms20092128
Frioni, 2014, Lactoferrin Differently Modulates the Inflammatory Response in Epithelial Models Mimicking Human Inflammatory and Infectious Diseases, Biometals, 27, 10.1007/s10534-014-9740-9
Valenti, 2017, Aerosolized Bovine Lactoferrin Reduces Neutrophils and Pro-Inflammatory Cytokines in Mouse Models of Pseudomonas Aeruginosa Lung Infections, Biochem Cell Biol, 95, 10.1139/bcb-2016-0050
Legrand, 2006, Interactions of Lactoferrin With Cells Involved in Immune Function, Biochem Cell Biol, 84, 10.1139/o06-045
Kuhara, 2006, Oral Administration of Lactoferrin Increases NK Cell Activity in Mice via Increased Production of IL-18 and Type I IFN in the Small Intestine, J Interferon Cytokine Res, 26, 10.1089/jir.2006.26.489
Puddu, 2009, Immunomodulatory Effects of Lactoferrin on Antigen Presenting Cells, Biochimie, 91, 10.1016/j.biochi.2008.05.005
Zimecki, 2021, The Potential for Lactoferrin to Reduce SARS-CoV-2 Induced Cytokine Storm, Int Immunopharmacol, 95, 10.1016/j.intimp.2021.107571
Valenti, 2018, Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense, Front Immunol, 9, 10.3389/fimmu.2018.00376
Nagler, 2004, Salivary Glands and the Aging Process: Mechanistic Aspects, Health-Status and Medicinal-Efficacy Monitoring, Biogerontology, 5, 10.1023/b:Bgen.0000038023.36727.50
Salvolini, 2000, Age-Related Modifications in Human Unstimulated Whole Saliva: A Biochemical Study, Aging (Milano), 12, 10.1007/bf03339875